LY2090314_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY2090314 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY2090314_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0681979
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0526537
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0399125
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0354762
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0316781
TPM3 tropomyosin 3 0.0280835
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0277215
TRIO trio Rho guanine nucleotide exchange factor 0.0277003
NIPBL Nipped-B homolog (Drosophila) 0.0274604
TFPI2 tissue factor pathway inhibitor 2 0.0270106
EEF2 eukaryotic translation elongation factor 2 0.0263638
ERRFI1 ERBB receptor feedback inhibitor 1 0.0249144
WNK1 WNK lysine deficient protein kinase 1 0.0244953
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0236461
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0228979
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0225894
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0218365
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208998
KTN1 kinectin 1 (kinesin receptor) 0.0206279
CLTC clathrin, heavy chain (Hc) 0.0199937
SFPQ splicing factor proline/glutamine-rich 0.019299
JMJD1C jumonji domain containing 1C 0.0190731
SPAG9 sperm associated antigen 9 0.018939
ANO6 anoctamin 6 0.0185676
XPO1 exportin 1 0.0183541
ELL2 elongation factor, RNA polymerase II, 2 0.0183195
ZCCHC7 zinc finger, CCHC domain containing 7 0.0182962
PCBP2 poly(rC) binding protein 2 0.0182606
ATP11A ATPase, class VI, type 11A 0.0174712
MARCHF4 membrane associated ring-CH-type finger 4 0.0172347
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0170751
COPA coatomer protein complex, subunit alpha 0.0166442
VMP1 vacuole membrane protein 1 0.016409
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0160391
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0157464
FXR1 fragile X mental retardation, autosomal homolog 1 0.0157161
TRIP12 thyroid hormone receptor interactor 12 0.0156903
IPO7 importin 7 0.0156484
GOLGB1 golgin B1 0.0155551
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.01543
NCKAP1 NCK-associated protein 1 0.0153052
HSPA8 heat shock 70kDa protein 8 0.0149194
TLN1 talin 1 0.0148886
CHD1 chromodomain helicase DNA binding protein 1 0.0148408
KDM2A lysine (K)-specific demethylase 2A 0.0146769
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0142072
PAPOLA poly(A) polymerase alpha 0.014085
RNF145 ring finger protein 145 0.0139692
DST dystonin 0.0138648
BIRC2 baculoviral IAP repeat containing 2 0.0137523
CSNK1A1 casein kinase 1, alpha 1 0.0134818
PREPL prolyl endopeptidase-like 0.0133503
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.013316
RB1CC1 RB1-inducible coiled-coil 1 0.0132376
GOLGA4 golgin A4 0.0132193
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0130622
PHIP pleckstrin homology domain interacting protein 0.0128544
YBX3 Y box binding protein 3 0.0127622
ATP13A3 ATPase type 13A3 0.0127054
NCAPG2 non-SMC condensin II complex, subunit G2 0.0126748
HOMER1 homer scaffolding protein 1 0.0125713
EXOC6B exocyst complex component 6B 0.0124333
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0124051
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0123921
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0123788
KMT2E lysine (K)-specific methyltransferase 2E 0.0123597
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0122904
GRAMD1B GRAM domain containing 1B 0.0122582
AKAP9 A kinase (PRKA) anchor protein 9 0.0121715
ZFAND3 zinc finger, AN1-type domain 3 0.0120252
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0120083
CAMKMT calmodulin-lysine N-methyltransferase 0.0119987
KIF5B kinesin family member 5B 0.011931
ZSWIM6 zinc finger, SWIM-type containing 6 0.0119223
PUM2 pumilio RNA-binding family member 2 0.0118357
SMAD3 SMAD family member 3 0.0118354
CSDE1 cold shock domain containing E1, RNA-binding 0.0117496
RTN4 reticulon 4 0.0117325
ANXA5 annexin A5 0.0117195
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0116628
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0115018
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0114278
GPHN gephyrin 0.0114235
CCNL1 cyclin L1 0.0114182
MYH9 myosin, heavy chain 9, non-muscle 0.0113374
NUP153 nucleoporin 153kDa 0.0113337
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0113291
STAG2 stromal antigen 2 0.011286
CRY1 cryptochrome circadian clock 1 0.0112845
UBA6 ubiquitin-like modifier activating enzyme 6 0.0112445
EIF4B eukaryotic translation initiation factor 4B 0.0111841
RASAL2 RAS protein activator like 2 0.0110548
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0110517
NUP58 nucleoporin 58 0.0110373
WDR43 WD repeat domain 43 0.0110217
HELZ helicase with zinc finger 0.0109773
MYPN myopalladin 0.0109311
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0109207
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0109148
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0109103

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.164688
TMSB10 thymosin beta 10 -0.102844
PTMA prothymosin, alpha -0.102123
RPL35A ribosomal protein L35a -0.0668169
AKAP12 A kinase (PRKA) anchor protein 12 -0.06637
HLA-B major histocompatibility complex, class I, B -0.0559138
TPT1 tumor protein, translationally-controlled 1 -0.0523252
VIM vimentin -0.0500922
RPS21 ribosomal protein S21 -0.0443728
RPL37A ribosomal protein L37a -0.0428837
MCL1 myeloid cell leukemia 1 -0.0428262
RPS8 ribosomal protein S8 -0.0427236
MT2A metallothionein 2A -0.0417951
RPLP1 ribosomal protein, large, P1 -0.0397488
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.039094
RPL31 ribosomal protein L31 -0.0384479
RPL37 ribosomal protein L37 -0.03839
IFI6 interferon, alpha-inducible protein 6 -0.0382218
RPS3 ribosomal protein S3 -0.0365294
RPS29 ribosomal protein S29 -0.0345427
RPS19 ribosomal protein S19 -0.0339003
RPS27 ribosomal protein S27 -0.0323747
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0316038
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0311167
ACTG1 actin gamma 1 -0.0310371
RPL19 ribosomal protein L19 -0.0306774
FTL ferritin, light polypeptide -0.029547
RPL34 ribosomal protein L34 -0.0292143
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0290849
RPS24 ribosomal protein S24 -0.028957
RPL26 ribosomal protein L26 -0.028765
RPS27A ribosomal protein S27a -0.0287529
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0286021
RPS15 ribosomal protein S15 -0.0285202
RPL23 ribosomal protein L23 -0.0280665
RPL38 ribosomal protein L38 -0.0278117
RPLP2 ribosomal protein, large, P2 -0.0270076
NCOA7 nuclear receptor coactivator 7 -0.0254633
EGR1 early growth response 1 -0.0252498
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0244621
CAVIN1 caveolae associated protein 1 -0.0242953
RPL36 ribosomal protein L36 -0.0240788
IER3 immediate early response 3 -0.0240085
RPL11 ribosomal protein L11 -0.0239729
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0235476
RPS10 ribosomal protein S10 -0.0233995
RPS6 ribosomal protein S6 -0.0216269
RPL36A ribosomal protein L36a -0.0214869
RPS13 ribosomal protein S13 -0.0208562
TPM4 tropomyosin 4 -0.0208038
RPS12 ribosomal protein S12 -0.020458
THSD4 thrombospondin, type I, domain containing 4 -0.0203134
RPS25 ribosomal protein S25 -0.0196756
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0196515
RYR3 ryanodine receptor 3 -0.0193623
S100A10 S100 calcium binding protein A10 -0.0190437
RPL9 ribosomal protein L9 -0.0189632
RPS14 ribosomal protein S14 -0.0188204
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0186655
MYL12B myosin, light chain 12B, regulatory -0.0184419
S100A6 S100 calcium binding protein A6 -0.0182715
WSB1 WD repeat and SOCS box containing 1 -0.0182022
AFF3 AF4/FMR2 family, member 3 -0.0180764
GNAS GNAS complex locus -0.0173526
HMGA2 high mobility group AT-hook 2 -0.0171789
ZMYND8 zinc finger, MYND-type containing 8 -0.0171695
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0170277
TPI1 triosephosphate isomerase 1 -0.017009
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0169942
RPS23 ribosomal protein S23 -0.0169029
CUX1 cut-like homeobox 1 -0.0161851
RPL8 ribosomal protein L8 -0.0160732
BASP1 brain abundant, membrane attached signal protein 1 -0.0159562
ZBTB20 zinc finger and BTB domain containing 20 -0.0159064
RPL28 ribosomal protein L28 -0.0156231
RPL7A ribosomal protein L7a -0.0154945
POTEF POTE ankyrin domain family, member F -0.014978
RPS16 ribosomal protein S16 -0.0148205
LOC102724023 ES1 protein homolog, mitochondrial -0.0147599
RPS17 ribosomal protein S17 -0.0144783
OSMR oncostatin M receptor -0.0144399
TPM2 tropomyosin 2 (beta) -0.0143403
RPL27 ribosomal protein L27 -0.0142029
RPL5 ribosomal protein L5 -0.0140399
ITSN1 intersectin 1 (SH3 domain protein) -0.0140155
S100A11 S100 calcium binding protein A11 -0.0139828
PYGL phosphorylase, glycogen, liver -0.0139112
PRH1 proline-rich protein HaeIII subfamily 1 -0.0134092
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0133935
RPL32 ribosomal protein L32 -0.0131418
RPL12 ribosomal protein L12 -0.0131382
RPL30 ribosomal protein L30 -0.0130513
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0130048
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0129132
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0128136
PFN1 profilin 1 -0.0127042
KPNB1 karyopherin (importin) beta 1 -0.0126546
UBB ubiquitin B -0.0125278
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0119781
RPL15 ribosomal protein L15 -0.011971