LY2090314_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY2090314 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY2090314_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0528343
RPS12 ribosomal protein S12 0.0456354
KYNU kynureninase 0.0448242
RPS6 ribosomal protein S6 0.0436649
RPL37A ribosomal protein L37a 0.0434024
RPS8 ribosomal protein S8 0.0433987
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0419028
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0388539
RPL31 ribosomal protein L31 0.037762
RPS3 ribosomal protein S3 0.0374416
VIM vimentin 0.0340714
DST dystonin 0.0316991
SQSTM1 sequestosome 1 0.0315837
RPS4X ribosomal protein S4, X-linked 0.031118
INTS6 integrator complex subunit 6 0.0307525
PRKN parkin RBR E3 ubiquitin protein ligase 0.0304957
MAML3 mastermind-like 3 (Drosophila) 0.029231
LDHA lactate dehydrogenase A 0.0289345
EEF2 eukaryotic translation elongation factor 2 0.0285093
SMOC1 SPARC related modular calcium binding 1 0.0283005
RPS23 ribosomal protein S23 0.0278943
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0275238
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0268231
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0268218
RPL26 ribosomal protein L26 0.0261896
PDLIM5 PDZ and LIM domain 5 0.0256212
RPS29 ribosomal protein S29 0.0253639
RPS2 ribosomal protein S2 0.0252577
ZSWIM6 zinc finger, SWIM-type containing 6 0.0237076
RPS17 ribosomal protein S17 0.0231021
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0229988
RPL7A ribosomal protein L7a 0.022887
RAD51B RAD51 paralog B 0.0222334
RPS27 ribosomal protein S27 0.0222196
FTL ferritin, light polypeptide 0.0218829
PDE10A phosphodiesterase 10A 0.0218547
ENO1 enolase 1, (alpha) 0.0215434
RACK1 receptor for activated C kinase 1 0.0214809
SH3KBP1 SH3-domain kinase binding protein 1 0.0214757
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0213487
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0211954
RPL9 ribosomal protein L9 0.0210177
ASPH aspartate beta-hydroxylase 0.0209203
EXT1 exostosin glycosyltransferase 1 0.0207543
MT2A metallothionein 2A 0.0207468
RPL12 ribosomal protein L12 0.020631
COL8A1 collagen, type VIII, alpha 1 0.0199042
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0198517
RPS13 ribosomal protein S13 0.0197601
RPL11 ribosomal protein L11 0.0192825
RPS27A ribosomal protein S27a 0.0192013
RPS19 ribosomal protein S19 0.0183988
VCL vinculin 0.017233
FMNL2 formin-like 2 0.0172018
RPL13A ribosomal protein L13a 0.0171609
RPL37 ribosomal protein L37 0.0169936
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0167578
TPT1 tumor protein, translationally-controlled 1 0.016651
RAB3B RAB3B, member RAS oncogene family 0.0165056
GOLGB1 golgin B1 0.0162702
PKM pyruvate kinase, muscle 0.0160969
GLRX glutaredoxin (thioltransferase) 0.0157706
RPS25 ribosomal protein S25 0.0153786
RPL23 ribosomal protein L23 0.0151411
SAMD4A sterile alpha motif domain containing 4A 0.0150025
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0147894
ATXN1 ataxin 1 0.0145711
HSPA8 heat shock 70kDa protein 8 0.0145565
RPL7 ribosomal protein L7 0.0144084
RPL36A ribosomal protein L36a 0.0142039
IGFBP3 insulin-like growth factor binding protein 3 0.0142021
SEPTIN9 septin 9 0.0140868
RPL27 ribosomal protein L27 0.0139975
ANXA2 annexin A2 0.013988
SMAD2 SMAD family member 2 0.0139563
CTSL cathepsin L 0.0138405
RPL36 ribosomal protein L36 0.0138176
EEF1G eukaryotic translation elongation factor 1 gamma 0.0137715
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0135987
EIF1 eukaryotic translation initiation factor 1 0.0135628
MAP7 microtubule-associated protein 7 0.0135074
APLP2 amyloid beta (A4) precursor-like protein 2 0.0133971
FNIP1 folliculin interacting protein 1 0.0130371
MCL1 myeloid cell leukemia 1 0.0129288
RPLP2 ribosomal protein, large, P2 0.0128873
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0127624
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0126911
AUTS2 autism susceptibility candidate 2 0.0125927
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0125292
TPM3 tropomyosin 3 0.0124625
RPL38 ribosomal protein L38 0.0123014
HDAC4 histone deacetylase 4 0.0120032
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0120015
NRDC nardilysin convertase 0.0118763
HSPE1 heat shock 10kDa protein 1 0.0118182
AKAP9 A kinase (PRKA) anchor protein 9 0.0117907
RPL19 ribosomal protein L19 0.0117535
KRT19 keratin 19, type I 0.0116229
STC2 stanniocalcin 2 0.0114057
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0113261

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.0935538
NAMPT nicotinamide phosphoribosyltransferase -0.0635407
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0546591
TMSB10 thymosin beta 10 -0.0415463
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0403595
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0384098
SPAG9 sperm associated antigen 9 -0.0320396
TM4SF1 transmembrane 4 L six family member 1 -0.0300382
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0289635
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0281698
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0265971
NRCAM neuronal cell adhesion molecule -0.0265055
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0263584
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0250011
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0230525
RTN4 reticulon 4 -0.0221064
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0217929
NEK7 NIMA-related kinase 7 -0.021008
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0207992
CD109 CD109 molecule -0.0205514
S100A6 S100 calcium binding protein A6 -0.0202788
TXNRD1 thioredoxin reductase 1 -0.0202705
OGA O-GlcNAcase -0.0199433
WARS1 tryptophanyl-tRNA synthetase 1 -0.0189936
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0186243
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0181892
ELL2 elongation factor, RNA polymerase II, 2 -0.0179347
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0179105
USP3 ubiquitin specific peptidase 3 -0.0179069
RBM39 RNA binding motif protein 39 -0.0173229
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0170349
GNAS GNAS complex locus -0.0168061
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0166968
PRKD3 protein kinase D3 -0.0166953
PGK1 phosphoglycerate kinase 1 -0.0166592
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0166319
TMSB4X thymosin beta 4, X-linked -0.0165917
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0165438
TRIO trio Rho guanine nucleotide exchange factor -0.0161342
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0158966
NCOA7 nuclear receptor coactivator 7 -0.0156369
TMX4 thioredoxin-related transmembrane protein 4 -0.0152316
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0151303
MATR3 matrin 3 -0.0147876
BIRC6 baculoviral IAP repeat containing 6 -0.0146393
AGFG1 ArfGAP with FG repeats 1 -0.0145798
CANX calnexin -0.0145459
BRWD3 bromodomain and WD repeat domain containing 3 -0.0143619
ZEB2 zinc finger E-box binding homeobox 2 -0.0143321
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0143041
TENT5A terminal nucleotidyltransferase 5A -0.0142375
PALLD palladin, cytoskeletal associated protein -0.0141528
PTGR1 prostaglandin reductase 1 -0.014003
SOX4 SRY (sex determining region Y)-box 4 -0.0137344
KMT2C lysine (K)-specific methyltransferase 2C -0.0134286
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0133918
NPEPPS aminopeptidase puromycin sensitive -0.0132535
SMYD3 SET and MYND domain containing 3 -0.01278
BASP1 brain abundant, membrane attached signal protein 1 -0.012766
WDR45B WD repeat domain 45B -0.0126007
LAMB1 laminin, beta 1 -0.0123623
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0122898
SAR1A secretion associated, Ras related GTPase 1A -0.0121429
HELZ helicase with zinc finger -0.0119313
CDK17 cyclin-dependent kinase 17 -0.0118176
SRPK2 SRSF protein kinase 2 -0.0117952
ZNF292 zinc finger protein 292 -0.0117926
KDM3A lysine (K)-specific demethylase 3A -0.011779
TFPI2 tissue factor pathway inhibitor 2 -0.0117207
FAM13A family with sequence similarity 13, member A -0.0115745
FNDC3B fibronectin type III domain containing 3B -0.0115216
ATP13A3 ATPase type 13A3 -0.0114435
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0113703
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0112425
QPCT glutaminyl-peptide cyclotransferase -0.0112
TM9SF3 transmembrane 9 superfamily member 3 -0.0110495
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0107351
SOD2 superoxide dismutase 2, mitochondrial -0.0106373
NCOR1 nuclear receptor corepressor 1 -0.0105864
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0105444
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0105374
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0105371
GARS1 glycyl-tRNA synthetase 1 -0.010537
RGS2 regulator of G-protein signaling 2 -0.0105123
TRA2A transformer 2 alpha homolog (Drosophila) -0.0104517
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0104334
ZMYND8 zinc finger, MYND-type containing 8 -0.0104317
IFIH1 interferon induced with helicase C domain 1 -0.0102607
UGCG UDP-glucose ceramide glucosyltransferase -0.0101726
INHBA inhibin, beta A -0.0100633
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0100233
WDFY2 WD repeat and FYVE domain containing 2 -0.0100126
ZFC3H1 zinc finger, C3H1-type containing -0.0100064
MARCHF6 membrane associated ring-CH-type finger 6 -0.0100035
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.00995984
PDGFA platelet-derived growth factor alpha polypeptide -0.00986872
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.00985187
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00982796
PBX1 pre-B-cell leukemia homeobox 1 -0.00976114
HILPDA hypoxia inducible lipid droplet-associated -0.00967719