LY2090314_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY2090314 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY2090314_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.120683
ZNF292 zinc finger protein 292 0.0810934
FNDC3B fibronectin type III domain containing 3B 0.0712241
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0695346
HDAC9 histone deacetylase 9 0.0645978
PHIP pleckstrin homology domain interacting protein 0.0593741
DST dystonin 0.0584697
AKAP9 A kinase (PRKA) anchor protein 9 0.0548994
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0548734
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0547066
FBXO11 F-box protein 11 0.0546411
KMT2C lysine (K)-specific methyltransferase 2C 0.0496939
LYST lysosomal trafficking regulator 0.0465852
SPAG9 sperm associated antigen 9 0.0417662
BIRC6 baculoviral IAP repeat containing 6 0.0413174
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0412069
ZFAND3 zinc finger, AN1-type domain 3 0.0408496
SRP54 signal recognition particle 54kDa 0.0401423
TENM3 teneurin transmembrane protein 3 0.0393224
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0364031
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0363173
CADM2 cell adhesion molecule 2 0.0353145
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0344105
PGK1 phosphoglycerate kinase 1 0.0339764
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0337859
PCBP2 poly(rC) binding protein 2 0.0336847
JMJD1C jumonji domain containing 1C 0.0332177
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0331988
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0316712
PLPP1 phospholipid phosphatase 1 0.0316143
PDIA6 protein disulfide isomerase family A, member 6 0.0315614
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0313394
NEBL nebulette 0.031114
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0308052
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.0304196
PDS5A PDS5 cohesin associated factor A 0.0300016
ADGRL3 adhesion G protein-coupled receptor L3 0.0299212
VMP1 vacuole membrane protein 1 0.0296081
NBEAL1 neurobeachin-like 1 0.0290654
SYT1 synaptotagmin I 0.0288761
SCAF11 SR-related CTD-associated factor 11 0.0288605
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0287565
PARD3B par-3 family cell polarity regulator beta 0.0286994
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0284628
ADGRL2 adhesion G protein-coupled receptor L2 0.0281554
KDM2A lysine (K)-specific demethylase 2A 0.027977
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0276655
SETD5 SET domain containing 5 0.0275086
USP34 ubiquitin specific peptidase 34 0.0268117
FBXL17 F-box and leucine-rich repeat protein 17 0.0267245
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.026473
COL11A1 collagen, type XI, alpha 1 0.026301
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0262635
SIK3 SIK family kinase 3 0.025548
TSC22D2 TSC22 domain family, member 2 0.0253432
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0251644
STRN3 striatin, calmodulin binding protein 3 0.0248614
AGO3 argonaute RISC catalytic component 3 0.0246701
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0245819
ZDBF2 zinc finger, DBF-type containing 2 0.0241793
RAB7A RAB7A, member RAS oncogene family 0.0239405
APLP2 amyloid beta (A4) precursor-like protein 2 0.0238969
NUMB numb homolog (Drosophila) 0.023882
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0238285
PICALM phosphatidylinositol binding clathrin assembly protein 0.0236613
BCAS3 breast carcinoma amplified sequence 3 0.023623
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.023612
PNISR PNN-interacting serine/arginine-rich protein 0.0234675
PGAP1 post-GPI attachment to proteins 1 0.0234587
TAOK1 TAO kinase 1 0.0230935
ITGAV integrin, alpha V 0.0230815
SLC38A9 solute carrier family 38, member 9 0.0230536
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0230449
COG5 component of oligomeric golgi complex 5 0.0230133
UBE3C ubiquitin protein ligase E3C 0.0230049
GPBP1 GC-rich promoter binding protein 1 0.0228079
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0226395
SLK STE20-like kinase 0.0226263
ANKRD12 ankyrin repeat domain 12 0.0225898
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0224674
N4BP2L2 NEDD4 binding protein 2-like 2 0.0218023
ARHGAP21 Rho GTPase activating protein 21 0.0215361
RNF13 ring finger protein 13 0.0215096
R3HDM1 R3H domain containing 1 0.021506
ARB2A ARB2 cotranscriptional regulator A 0.0214604
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0213065
NRIP1 nuclear receptor interacting protein 1 0.0210316
PCDH18 protocadherin 18 0.0210108
SMYD3 SET and MYND domain containing 3 0.0210065
ZNF207 zinc finger protein 207 0.0209974
KTN1 kinectin 1 (kinesin receptor) 0.0208785
SERINC3 serine incorporator 3 0.0208611
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0207231
MB21D2 Mab-21 domain containing 2 0.0206235
ZFP36L1 ZFP36 ring finger protein-like 1 0.020596
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0205918
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0205754
KLHL5 kelch-like family member 5 0.0205033
FAM168A family with sequence similarity 168, member A 0.0204933
LATS2 large tumor suppressor kinase 2 0.0204848

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.110971
VIM vimentin -0.0838958
ACTG1 actin gamma 1 -0.0722345
RPLP1 ribosomal protein, large, P1 -0.0719504
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0714311
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0708648
MKI67 marker of proliferation Ki-67 -0.0707554
RPS8 ribosomal protein S8 -0.0591754
TMSB10 thymosin beta 10 -0.0574665
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0571957
GNAS GNAS complex locus -0.0561092
TMSB4X thymosin beta 4, X-linked -0.0553953
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0549272
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.050565
SRP72 signal recognition particle 72kDa -0.0476173
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0474297
HMGB2 high mobility group box 2 -0.0463831
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0435904
RPS16 ribosomal protein S16 -0.0417495
CENPF centromere protein F, 350/400kDa -0.041532
RPL11 ribosomal protein L11 -0.0396704
ACTN4 actinin, alpha 4 -0.0394476
RPS21 ribosomal protein S21 -0.0393913
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0392247
HMGB1 high mobility group box 1 -0.0380363
MYL12B myosin, light chain 12B, regulatory -0.035783
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0329998
AFF4 AF4/FMR2 family, member 4 -0.0316939
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0305904
RPS19 ribosomal protein S19 -0.0305163
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0299496
DEK DEK proto-oncogene -0.0298675
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0297763
RPS12 ribosomal protein S12 -0.0289167
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0284525
PTMA prothymosin, alpha -0.0282744
S100A10 S100 calcium binding protein A10 -0.027924
RPL38 ribosomal protein L38 -0.0272747
RPLP2 ribosomal protein, large, P2 -0.0270688
CAVIN1 caveolae associated protein 1 -0.0269317
SFRP4 secreted frizzled-related protein 4 -0.0266747
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0264566
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0263396
RACK1 receptor for activated C kinase 1 -0.0262849
CNRIP1 cannabinoid receptor interacting protein 1 -0.0262352
YBX1 Y box binding protein 1 -0.0260901
RPS10 ribosomal protein S10 -0.0259996
RPLP0 ribosomal protein, large, P0 -0.0259701
FOXP2 forkhead box P2 -0.0257991
FNBP1L formin binding protein 1-like -0.0257702
RPS6 ribosomal protein S6 -0.0256288
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0254216
RPL19 ribosomal protein L19 -0.0254068
TPT1 tumor protein, translationally-controlled 1 -0.0253311
SERF2 small EDRK-rich factor 2 -0.0252986
STAG2 stromal antigen 2 -0.0251823
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0251722
RPL34 ribosomal protein L34 -0.0251059
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0246373
RAD21 RAD21 homolog (S. pombe) -0.0244743
TPR translocated promoter region, nuclear basket protein -0.0244265
TOP1 topoisomerase (DNA) I -0.0242935
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0242541
PUM1 pumilio RNA-binding family member 1 -0.0240134
RPL12 ribosomal protein L12 -0.0240039
KIF4A kinesin family member 4A -0.0240019
NALF1 NALCN channel auxiliary factor 1 -0.0235136
HDAC2 histone deacetylase 2 -0.0234742
RLF rearranged L-myc fusion -0.0234506
PCDH9 protocadherin 9 -0.0232982
RPS3 ribosomal protein S3 -0.0232934
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0232902
KNL1 kinetochore scaffold 1 -0.0232279
RPS15 ribosomal protein S15 -0.023123
USP1 ubiquitin specific peptidase 1 -0.0230934
PRDX1 peroxiredoxin 1 -0.0226912
RPL30 ribosomal protein L30 -0.022388
RPL4 ribosomal protein L4 -0.0222479
FTL ferritin, light polypeptide -0.0222459
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0221862
RPL35A ribosomal protein L35a -0.0221576
CDH19 cadherin 19, type 2 -0.0219955
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0219825
NAP1L1 nucleosome assembly protein 1-like 1 -0.0219559
CCNA2 cyclin A2 -0.0217334
MATR3 matrin 3 -0.0217213
ATP5F1E ATP synthase F1 subunit epsilon -0.0216593
THBS1 thrombospondin 1 -0.0213462
RPL36 ribosomal protein L36 -0.0213091
SGO2 shugoshin 2 -0.0212291
RPS27 ribosomal protein S27 -0.021187
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0211178
RPS28 ribosomal protein S28 -0.0205718
YARS1 tyrosyl-tRNA synthetase 1 -0.0205352
RPL9 ribosomal protein L9 -0.0203935
ANLN anillin, actin binding protein -0.0203337
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0200668
RPL27A ribosomal protein L27a -0.0198409
SRSF11 serine/arginine-rich splicing factor 11 -0.0197765
PARK7 parkinson protein 7 -0.0197641