LY2090314_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LY2090314 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LY2090314_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0727397
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0649566
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0459826
HMGA2 high mobility group AT-hook 2 0.0438746
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0436233
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0430451
TRIO trio Rho guanine nucleotide exchange factor 0.0426201
KYNU kynureninase 0.0409875
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0369108
AKAP12 A kinase (PRKA) anchor protein 12 0.0368381
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0343284
RND3 Rho family GTPase 3 0.0341611
IGFBP3 insulin-like growth factor binding protein 3 0.0331992
ZBTB38 zinc finger and BTB domain containing 38 0.031288
INTS6 integrator complex subunit 6 0.0306239
CDH13 cadherin 13 0.0299734
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0299452
ZSWIM6 zinc finger, SWIM-type containing 6 0.0296684
GLIS3 GLIS family zinc finger 3 0.0293343
LDHA lactate dehydrogenase A 0.028979
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0278372
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.027716
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0266503
FNIP1 folliculin interacting protein 1 0.0262568
ASPH aspartate beta-hydroxylase 0.0247847
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0239057
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0225029
DST dystonin 0.0224076
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0216863
ATXN1 ataxin 1 0.0207852
TMEM132D transmembrane protein 132D 0.0206232
EXT1 exostosin glycosyltransferase 1 0.0201653
MACF1 microtubule-actin crosslinking factor 1 0.0201297
AFF3 AF4/FMR2 family, member 3 0.0190919
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0190053
ZHX2 zinc fingers and homeoboxes 2 0.0186502
EGFR epidermal growth factor receptor 0.0184179
STC2 stanniocalcin 2 0.0181351
SEPTIN9 septin 9 0.0180073
SMYD3 SET and MYND domain containing 3 0.0179831
GOLGB1 golgin B1 0.0179599
SDK1 sidekick cell adhesion molecule 1 0.0172295
ZMIZ1 zinc finger, MIZ-type containing 1 0.0170873
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0165512
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0165016
BACE2 beta-site APP-cleaving enzyme 2 0.0161818
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0151646
KAT6B K(lysine) acetyltransferase 6B 0.0151035
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0150995
FBXL7 F-box and leucine-rich repeat protein 7 0.0150005
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0148332
SQSTM1 sequestosome 1 0.0145389
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0139316
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0139176
BICC1 BicC family RNA binding protein 1 0.0138109
OPTN optineurin 0.0136425
COL5A1 collagen, type V, alpha 1 0.013345
RAD51B RAD51 paralog B 0.0132702
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0132467
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0131614
PPARD peroxisome proliferator-activated receptor delta 0.0129659
TLE4 transducin-like enhancer of split 4 0.0128898
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.012878
RAI14 retinoic acid induced 14 0.0128375
EFNA5 ephrin-A5 0.0126838
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0126166
DOCK5 dedicator of cytokinesis 5 0.0126142
PHF3 PHD finger protein 3 0.012603
PRELID2 PRELI domain containing 2 0.0123399
JMJD1C jumonji domain containing 1C 0.0121965
TBC1D22A TBC1 domain family, member 22A 0.0121849
RUNX1 runt-related transcription factor 1 0.0121845
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0121101
IRAK2 interleukin-1 receptor-associated kinase 2 0.0120284
FRMPD4 FERM and PDZ domain containing 4 0.0119481
MBNL2 muscleblind-like splicing regulator 2 0.01192
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0116322
EXOC4 exocyst complex component 4 0.0114559
BRD2 bromodomain containing 2 0.0112423
SP100 SP100 nuclear antigen 0.0110953
VEGFA vascular endothelial growth factor A 0.0110039
USP53 ubiquitin specific peptidase 53 0.0109852
EPHA6 EPH receptor A6 0.0109387
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0107993
ARHGAP22 Rho GTPase activating protein 22 0.0107293
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0105101
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0103495
PTH2R parathyroid hormone 2 receptor 0.0102908
PDE10A phosphodiesterase 10A 0.0100947
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0100522
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0100505
BTG1 B-cell translocation gene 1, anti-proliferative 0.0100497
VAC14 Vac14 homolog (S. cerevisiae) 0.00988795
VCAN versican 0.00982137
PCBP3 poly(rC) binding protein 3 0.00980092
MYO1E myosin IE 0.00977945
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.00976684
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00972399
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.00963236
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.00955348

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.131995
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0894287
TMSB10 thymosin beta 10 -0.0853365
MYH9 myosin, heavy chain 9, non-muscle -0.0619368
NAMPT nicotinamide phosphoribosyltransferase -0.0603672
SOD2 superoxide dismutase 2, mitochondrial -0.0588674
FN1 fibronectin 1 -0.0579657
HLA-B major histocompatibility complex, class I, B -0.057195
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.057059
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0551085
UBC ubiquitin C -0.0510715
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0475583
PTMA prothymosin, alpha -0.0463462
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0461328
PGK1 phosphoglycerate kinase 1 -0.0435336
RPS27A ribosomal protein S27a -0.0399825
AHNAK AHNAK nucleoprotein -0.0372376
RPL23 ribosomal protein L23 -0.0370885
RTN4 reticulon 4 -0.0368932
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0340007
COL1A1 collagen, type I, alpha 1 -0.030626
TPM4 tropomyosin 4 -0.0297222
UGCG UDP-glucose ceramide glucosyltransferase -0.0295286
RPLP2 ribosomal protein, large, P2 -0.0294484
LOC112694756 uncharaterized LOC112694756 -0.0288057
FTL ferritin, light polypeptide -0.0286134
ENO1 enolase 1, (alpha) -0.0279143
PCBP2 poly(rC) binding protein 2 -0.0271137
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0267606
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0265138
FLNA filamin A, alpha -0.0264419
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0263054
ZFAND3 zinc finger, AN1-type domain 3 -0.0261646
EEF2 eukaryotic translation elongation factor 2 -0.0260293
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0258509
OGA O-GlcNAcase -0.0252001
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0251228
POTEF POTE ankyrin domain family, member F -0.0220147
ZNF292 zinc finger protein 292 -0.0218219
PKM pyruvate kinase, muscle -0.021518
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0211613
RPLP1 ribosomal protein, large, P1 -0.0210934
ACTG1 actin gamma 1 -0.0208844
TMSB4X thymosin beta 4, X-linked -0.02082
SLC38A1 solute carrier family 38, member 1 -0.020813
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0204733
RPL19 ribosomal protein L19 -0.0200988
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0199651
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0197513
MKI67 marker of proliferation Ki-67 -0.019733
FRMD4A FERM domain containing 4A -0.0195746
RPS24 ribosomal protein S24 -0.0191458
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0190811
RPL35A ribosomal protein L35a -0.0188361
MATR3 matrin 3 -0.0187675
COL1A2 collagen, type I, alpha 2 -0.0186557
ANLN anillin, actin binding protein -0.0183304
TXNRD1 thioredoxin reductase 1 -0.0177677
APP amyloid beta (A4) precursor protein -0.0173968
TUBB tubulin, beta class I -0.0172555
KIF4A kinesin family member 4A -0.0169301
CENPF centromere protein F, 350/400kDa -0.0166662
RPS12 ribosomal protein S12 -0.016613
HLA-A major histocompatibility complex, class I, A -0.0165913
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0164172
TMEM41B transmembrane protein 41B -0.0163004
ICAM1 intercellular adhesion molecule 1 -0.0161497
SDC4 syndecan 4 -0.0161021
GNAS GNAS complex locus -0.0160823
RPL36A ribosomal protein L36a -0.016049
TM9SF3 transmembrane 9 superfamily member 3 -0.0160248
WSB1 WD repeat and SOCS box containing 1 -0.0157639
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0157489
RPS3 ribosomal protein S3 -0.0156835
SEPTIN7 septin 7 -0.0156228
CKAP5 cytoskeleton associated protein 5 -0.0154881
ACTN4 actinin, alpha 4 -0.0150454
TPM1 tropomyosin 1 (alpha) -0.0150391
TPX2 TPX2, microtubule-associated -0.0149874
HMGB2 high mobility group box 2 -0.0149811
EGR1 early growth response 1 -0.0147828
ZNFX1 zinc finger, NFX1-type containing 1 -0.0147505
THBS1 thrombospondin 1 -0.0146547
DEK DEK proto-oncogene -0.0146119
CALU calumenin -0.0146078
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0145795
TMEM123 transmembrane protein 123 -0.0144091
IFITM3 interferon induced transmembrane protein 3 -0.0143865
RPS21 ribosomal protein S21 -0.0141977
ATP13A3 ATPase type 13A3 -0.0141587
THOC2 THO complex 2 -0.0140749
FLNB filamin B, beta -0.0139898
DENND5A DENN/MADD domain containing 5A -0.0138571
RPL15 ribosomal protein L15 -0.0138293
NT5C2 5'-nucleotidase, cytosolic II -0.0136943
CSDE1 cold shock domain containing E1, RNA-binding -0.0136206
RAI1 retinoic acid induced 1 -0.0135308
CD63 CD63 molecule -0.0134957
RHOA ras homolog family member A -0.0134938
DLG1 discs, large homolog 1 (Drosophila) -0.0134699