Lamellipodium Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. (Gene Ontology, GO_0030027)
External Link http://amigo.geneontology.org/amigo/term/GO:0030027
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Genes

142 proteins localized to the Lamellipodium cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 5.0
DGKZ diacylglycerol kinase, zeta 5.0
FLOT1 flotillin 1 5.0
FLOT2 flotillin 2 5.0
SSH1 slingshot protein phosphatase 1 5.0
PODXL podocalyxin-like 5.0
MYLK myosin light chain kinase 5.0
SCYL3 SCY1-like 3 (S. cerevisiae) 5.0
CD44 CD44 molecule (Indian blood group) 5.0
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 5.0
CTTN cortactin 5.0
CIB1 calcium and integrin binding 1 (calmyrin) 5.0
PALLD palladin, cytoskeletal associated protein 5.0
GLMN glomulin, FKBP associated protein 5.0
TSC1 tuberous sclerosis 1 5.0
PLEK2 pleckstrin 2 5.0
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 5.0
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 5.0
PLCE1 phospholipase C, epsilon 1 5.0
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 5.0
PTPRM protein tyrosine phosphatase, receptor type, M 5.0
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 5.0
CORO1A coronin, actin binding protein, 1A 5.0
WASF2 WAS protein family, member 2 5.0
CCDC88A coiled-coil domain containing 88A 5.0
KITLG KIT ligand 5.0
PLCG1 phospholipase C, gamma 1 5.0
PPP1R9B protein phosphatase 1, regulatory subunit 9B 5.0
PEAR1 platelet endothelial aggregation receptor 1 5.0
KPTN kaptin (actin binding protein) 5.0
CORO1C coronin, actin binding protein, 1C 5.0
CORO1B coronin, actin binding protein, 1B 5.0
STX3 syntaxin 3 5.0
STX2 syntaxin 2 5.0
STX4 syntaxin 4 5.0
PKN2 protein kinase N2 5.0
PDLIM4 PDZ and LIM domain 4 5.0
PTK2B protein tyrosine kinase 2 beta 5.0
SLC39A6 solute carrier family 39 (zinc transporter), member 6 5.0
VAMP7 vesicle-associated membrane protein 7 5.0
CASP8 caspase 8, apoptosis-related cysteine peptidase 5.0
ITGAV integrin, alpha V 5.0
ABLIM3 actin binding LIM protein family, member 3 5.0
PARVB parvin, beta 5.0
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 5.0
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 5.0
NCOA3 nuclear receptor coactivator 3 5.0
STMN2 stathmin 2 5.0
DPP4 dipeptidyl-peptidase 4 5.0
EPHA2 EPH receptor A2 5.0
ABLIM1 actin binding LIM protein 1 5.0
SPATA13 spermatogenesis associated 13 5.0
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 5.0
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 5.0
ABI2 abl-interactor 2 5.0
ABI3 ABI family, member 3 5.0
ABI1 abl-interactor 1 5.0
CARMIL2 capping protein regulator and myosin 1 linker 2 5.0
TESC tescalcin 5.0
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 5.0
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 5.0
SPEF1 sperm flagellar 1 5.0
ANTXR1 anthrax toxin receptor 1 5.0
AMOT angiomotin 5.0
VIL1 villin 1 5.0
IQGAP2 IQ motif containing GTPase activating protein 2 5.0
SH3BP1 SH3-domain binding protein 1 5.0
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 5.0
PLXND1 plexin D1 5.0
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 5.0
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 5.0
SYNE2 spectrin repeat containing, nuclear envelope 2 5.0
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 5.0
VASP vasodilator-stimulated phosphoprotein 5.0
AVIL advillin 5.0
CLRN1 clarin 1 5.0
PROC protein C (inactivator of coagulation factors Va and VIIIa) 5.0
FGD2 FYVE, RhoGEF and PH domain containing 2 4.0
FGD4 FYVE, RhoGEF and PH domain containing 4 4.0
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 4.0
RAB13 RAB13, member RAS oncogene family 4.0
ABITRAM actin binding transcription modulator 4.0
RDX radixin 4.0
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 4.0
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 4.0
FGD5 FYVE, RhoGEF and PH domain containing 5 4.0
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 4.0
CARMIL1 capping protein regulator and myosin 1 linker 1 4.0
PTPRU protein tyrosine phosphatase, receptor type, U 4.0
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 4.0
FGD6 FYVE, RhoGEF and PH domain containing 6 4.0
FGD1 FYVE, RhoGEF and PH domain containing 1 4.0
FGD3 FYVE, RhoGEF and PH domain containing 3 4.0
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 4.0
PHACTR4 phosphatase and actin regulator 4 4.0
DUSP22 dual specificity phosphatase 22 4.0
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 4.0
POTEF POTE ankyrin domain family, member F 4.0
LIMK1 LIM domain kinase 1 4.0
PXDN peroxidasin 4.0
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 4.0
RHOA ras homolog family member A 4.0
P4HB prolyl 4-hydroxylase, beta polypeptide 4.0
FYCO1 FYVE and coiled-coil domain containing 1 4.0
AIF1 allograft inflammatory factor 1 4.0
UNC5C unc-5 homolog C (C. elegans) 4.0
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 4.0
CYFIP1 cytoplasmic FMR1 interacting protein 1 4.0
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 4.0
PDPN podoplanin 4.0
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 4.0
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 4.0
PRKD2 protein kinase D2 4.0
DPYSL3 dihydropyrimidinase-like 3 4.0
SHTN1 shootin 1 4.0
TUBB3 tubulin, beta 3 class III 4.0
FSCN1 fascin actin-bundling protein 1 4.0
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 4.0
SH3RF1 SH3 domain containing ring finger 1 4.0
EVL Enah/Vasp-like 4.0
FAM89B family with sequence similarity 89, member B 4.0
PHPT1 phosphohistidine phosphatase 1 4.0
ITGB1BP1 integrin beta 1 binding protein 1 4.0
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 4.0
NME2 NME/NM23 nucleoside diphosphate kinase 2 4.0
AKT1 v-akt murine thymoma viral oncogene homolog 1 4.0
DBNL drebrin-like 4.0
ACTG2 actin, gamma 2, smooth muscle, enteric 3.0
ACTA2 actin, alpha 2, smooth muscle, aorta 3.0
ACTC1 actin, alpha, cardiac muscle 1 3.0
ARHGAP31 Rho GTPase activating protein 31 3.0
ACTA1 actin, alpha 1, skeletal muscle 3.0
WASF3 WAS protein family, member 3 3.0
MYO9B myosin IXB 3.0
RNASEH1 ribonuclease H1 3.0
HAX1 HCLS1 associated protein X-1 3.0
NCKAP1 NCK-associated protein 1 3.0
FSCN3 fascin actin-bundling protein 3, testicular 3.0
TWF2 twinfilin actin binding protein 2 3.0
TRPV4 transient receptor potential cation channel, subfamily V, member 4 3.0
WASF1 WAS protein family, member 1 3.0
CARMIL3 capping protein regulator and myosin 1 linker 3 3.0