| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.134266 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.132977 |
| PODXL | podocalyxin-like | 0.128126 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.100228 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0912158 |
| CD44 | CD44 molecule (Indian blood group) | 0.0851618 |
| NDRG1 | N-myc downstream regulated 1 | 0.084736 |
| FLNB | filamin B, beta | 0.0774496 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0694232 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0692435 |
| LDHA | lactate dehydrogenase A | 0.0597194 |
| SEPTIN9 | septin 9 | 0.0596955 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0584554 |
| SQSTM1 | sequestosome 1 | 0.0575049 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0565349 |
| NAV2 | neuron navigator 2 | 0.0548727 |
| FLNA | filamin A, alpha | 0.054568 |
| PLAT | plasminogen activator, tissue | 0.0539824 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0538899 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0524128 |
| THBS2 | thrombospondin 2 | 0.0520035 |
| HDAC9 | histone deacetylase 9 | 0.0518051 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0511052 |
| COL3A1 | collagen, type III, alpha 1 | 0.0493687 |
| TPM3 | tropomyosin 3 | 0.0473498 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0433699 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0431923 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0431291 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0428979 |
| ARRDC3 | arrestin domain containing 3 | 0.0393584 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0385461 |
| APP | amyloid beta (A4) precursor protein | 0.0381244 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0379387 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.036982 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0369567 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0365036 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0358709 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0354905 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0350414 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0350244 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0350134 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0347504 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0336938 |
| CALR | calreticulin | 0.0326284 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0324499 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0324166 |
| LOXL2 | lysyl oxidase-like 2 | 0.0317907 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.031133 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.030655 |
| HLA-B | major histocompatibility complex, class I, B | 0.0299683 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0294923 |
| MSN | moesin | 0.0291383 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0290149 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0289409 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0284532 |
| ATXN1 | ataxin 1 | 0.0280544 |
| MT2A | metallothionein 2A | 0.0277966 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0276069 |
| KLF6 | Kruppel-like factor 6 | 0.0273139 |
| SMAD3 | SMAD family member 3 | 0.0273078 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0272764 |
| RPS3 | ribosomal protein S3 | 0.0269597 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0265634 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0264504 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0262063 |
| FNIP1 | folliculin interacting protein 1 | 0.0255432 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0252216 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0251616 |
| RPL26 | ribosomal protein L26 | 0.0250274 |
| GANAB | glucosidase, alpha; neutral AB | 0.0248293 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0245336 |
| CD99 | CD99 molecule | 0.0243085 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0237226 |
| PLEC | plectin | 0.0236857 |
| ZNF292 | zinc finger protein 292 | 0.0236786 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0236053 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.023364 |
| RUNX1 | runt-related transcription factor 1 | 0.0232244 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.0230463 |
| RPL37A | ribosomal protein L37a | 0.022791 |
| TLE4 | transducin-like enhancer of split 4 | 0.0226925 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0226254 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0225771 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0225227 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0222381 |
| NCKAP1 | NCK-associated protein 1 | 0.0221165 |
| SMYD3 | SET and MYND domain containing 3 | 0.0219231 |
| ANXA2 | annexin A2 | 0.0219092 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0215242 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0214971 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0213845 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0210868 |
| RPS2 | ribosomal protein S2 | 0.0209274 |
| MB21D2 | Mab-21 domain containing 2 | 0.0209044 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0208168 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0207464 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0206515 |
| ARFGEF3 | ARFGEF family member 3 | 0.0203303 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0202673 |
| CD109 | CD109 molecule | 0.0202667 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.167881 |
| VIM | vimentin | -0.167236 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.138524 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.127655 |
| TMSB10 | thymosin beta 10 | -0.110303 |
| FN1 | fibronectin 1 | -0.0930042 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0856954 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0716239 |
| PTMA | prothymosin, alpha | -0.0650536 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.064327 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0629676 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0627287 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0578758 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0564022 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0543472 |
| PRSS23 | protease, serine, 23 | -0.046081 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0441865 |
| RIGI | RNA sensor RIG-I | -0.0426757 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0423359 |
| TAGLN2 | transgelin 2 | -0.0401739 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.040044 |
| COL5A1 | collagen, type V, alpha 1 | -0.0392978 |
| SUCNR1 | succinate receptor 1 | -0.0382642 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0375639 |
| AHNAK | AHNAK nucleoprotein | -0.0364925 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0360479 |
| FBN1 | fibrillin 1 | -0.0343862 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0337717 |
| RRBP1 | ribosome binding protein 1 | -0.0336636 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0322292 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0305343 |
| COL1A2 | collagen, type I, alpha 2 | -0.030413 |
| MX2 | MX dynamin-like GTPase 2 | -0.0298131 |
| MAP1B | microtubule-associated protein 1B | -0.0293392 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0289172 |
| LOX | lysyl oxidase | -0.0283144 |
| LRRC17 | leucine rich repeat containing 17 | -0.0278383 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0276871 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0267139 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0266978 |
| LMNA | lamin A/C | -0.0266737 |
| CAVIN1 | caveolae associated protein 1 | -0.0262122 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0259588 |
| IL7R | interleukin 7 receptor | -0.0258367 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0249039 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0247051 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0245801 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0245678 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0244092 |
| TNS3 | tensin 3 | -0.024283 |
| SEPTIN7 | septin 7 | -0.0234039 |
| S100A6 | S100 calcium binding protein A6 | -0.0222795 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0221466 |
| CSTB | cystatin B (stefin B) | -0.0220833 |
| TPM1 | tropomyosin 1 (alpha) | -0.021929 |
| CCND1 | cyclin D1 | -0.0218799 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0212379 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0209727 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0208617 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0208131 |
| S100A10 | S100 calcium binding protein A10 | -0.0203524 |
| MED13L | mediator complex subunit 13-like | -0.0202458 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.020053 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0197999 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0195374 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0190737 |
| JAZF1 | JAZF zinc finger 1 | -0.0185812 |
| SP100 | SP100 nuclear antigen | -0.018056 |
| GNAS | GNAS complex locus | -0.0180346 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0180064 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0180012 |
| NAV1 | neuron navigator 1 | -0.017564 |
| HSPB1 | heat shock 27kDa protein 1 | -0.017422 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0171031 |
| FGF13 | fibroblast growth factor 13 | -0.0170806 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0170065 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.016744 |
| CUX1 | cut-like homeobox 1 | -0.0165196 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0163228 |
| COL1A1 | collagen, type I, alpha 1 | -0.016264 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0161643 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0160515 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0160011 |
| CYTH3 | cytohesin 3 | -0.0157884 |
| NPR2 | natriuretic peptide receptor 2 | -0.0157504 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.015676 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0154829 |
| FTL | ferritin, light polypeptide | -0.015115 |
| PKM | pyruvate kinase, muscle | -0.0151106 |
| LMAN1 | lectin, mannose-binding, 1 | -0.015018 |
| S100A4 | S100 calcium binding protein A4 | -0.0149988 |
| KRT81 | keratin 81, type II | -0.01495 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0147167 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0143006 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0142295 |
| AEBP2 | AE binding protein 2 | -0.0142113 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0141978 |
| FRMD4A | FERM domain containing 4A | -0.0141621 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0140915 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.013817 |
