| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.147679 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.131945 |
| AREG | amphiregulin | 0.105847 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0989574 |
| RPS12 | ribosomal protein S12 | 0.0948736 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.09174 |
| HMGA2 | high mobility group AT-hook 2 | 0.0863721 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0808891 |
| RPS3 | ribosomal protein S3 | 0.0800885 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0769252 |
| RPL37A | ribosomal protein L37a | 0.0670968 |
| RPS8 | ribosomal protein S8 | 0.0660912 |
| RPL26 | ribosomal protein L26 | 0.0641114 |
| PCDH7 | protocadherin 7 | 0.0623701 |
| RPS27A | ribosomal protein S27a | 0.0580804 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0576745 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0559515 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0522873 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0517527 |
| EHBP1 | EH domain binding protein 1 | 0.0515462 |
| INTS6 | integrator complex subunit 6 | 0.0508756 |
| EGR1 | early growth response 1 | 0.0505055 |
| ACTG1 | actin gamma 1 | 0.0487714 |
| RPL35A | ribosomal protein L35a | 0.0453303 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0451173 |
| ASPH | aspartate beta-hydroxylase | 0.0446227 |
| RPL13A | ribosomal protein L13a | 0.0430212 |
| PRDX1 | peroxiredoxin 1 | 0.0422941 |
| RPS29 | ribosomal protein S29 | 0.0420288 |
| CMIP | c-Maf inducing protein | 0.0419794 |
| RPS23 | ribosomal protein S23 | 0.0411469 |
| RPS13 | ribosomal protein S13 | 0.0409521 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0408914 |
| ADIPOR2 | adiponectin receptor 2 | 0.0402055 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0391004 |
| RPL23 | ribosomal protein L23 | 0.0370088 |
| RPL37 | ribosomal protein L37 | 0.036646 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0354653 |
| RPS2 | ribosomal protein S2 | 0.034635 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0345168 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0333738 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0332344 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0327059 |
| TPM3 | tropomyosin 3 | 0.0326062 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0318621 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.03151 |
| HMGA1 | high mobility group AT-hook 1 | 0.0311174 |
| RACK1 | receptor for activated C kinase 1 | 0.0306977 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0295957 |
| LRRC23 | leucine rich repeat containing 23 | 0.0289958 |
| ATP11A | ATPase, class VI, type 11A | 0.0286544 |
| RPL9 | ribosomal protein L9 | 0.0285271 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0280525 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0273848 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0271942 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0269949 |
| GANAB | glucosidase, alpha; neutral AB | 0.0269801 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.026259 |
| RPL11 | ribosomal protein L11 | 0.0262184 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0261363 |
| PDCD6 | programmed cell death 6 | 0.0259367 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0255091 |
| RPL38 | ribosomal protein L38 | 0.0250474 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0246489 |
| RPS7 | ribosomal protein S7 | 0.0245652 |
| RPL5 | ribosomal protein L5 | 0.0244041 |
| DENND5A | DENN/MADD domain containing 5A | 0.0241703 |
| RPL6 | ribosomal protein L6 | 0.023451 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0234253 |
| RPS25 | ribosomal protein S25 | 0.0227874 |
| CALR | calreticulin | 0.0227145 |
| PRKCE | protein kinase C, epsilon | 0.0224243 |
| RPLP2 | ribosomal protein, large, P2 | 0.0223795 |
| ANK2 | ankyrin 2, neuronal | 0.022292 |
| RPS27 | ribosomal protein S27 | 0.0222318 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0222252 |
| RPS10 | ribosomal protein S10 | 0.0218394 |
| PCDH9 | protocadherin 9 | 0.0217511 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0213822 |
| INTS4 | integrator complex subunit 4 | 0.0213599 |
| SETX | senataxin | 0.0213264 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.0213056 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0212999 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0210146 |
| RPL36A | ribosomal protein L36a | 0.0210081 |
| CCN2 | cellular communication network factor 2 | 0.0209991 |
| PDGFC | platelet derived growth factor C | 0.0209916 |
| NEGR1 | neuronal growth regulator 1 | 0.0206637 |
| RPL36 | ribosomal protein L36 | 0.0206181 |
| EXOC4 | exocyst complex component 4 | 0.0203733 |
| MCL1 | myeloid cell leukemia 1 | 0.0202197 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0199801 |
| NRXN3 | neurexin 3 | 0.0199543 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0198846 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0195151 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0194587 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0194493 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0193256 |
| MUSK | muscle, skeletal, receptor tyrosine kinase | 0.0192527 |
| HSPE1 | heat shock 10kDa protein 1 | 0.018796 |
| Symbol | Name | Standardized Value |
|---|---|---|
| XPO1 | exportin 1 | -0.0671359 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0668835 |
| PTMA | prothymosin, alpha | -0.064249 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.062786 |
| NLGN1 | neuroligin 1 | -0.0620712 |
| TMSB10 | thymosin beta 10 | -0.0609557 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0601609 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0552239 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0537275 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0531395 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0511359 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.050093 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0498598 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0497604 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.047631 |
| CCNL1 | cyclin L1 | -0.0468995 |
| H1-0 | H1.0 linker histone | -0.0449223 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0446138 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0443071 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0428653 |
| MGAT4C | MGAT4 family, member C | -0.0425134 |
| NEK7 | NIMA-related kinase 7 | -0.041892 |
| ECT2 | epithelial cell transforming 2 | -0.0414413 |
| PTMS | parathymosin | -0.0410546 |
| CPOX | coproporphyrinogen oxidase | -0.0406529 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0405347 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0400827 |
| ZNF292 | zinc finger protein 292 | -0.0380811 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0366436 |
| LMO7 | LIM domain 7 | -0.0365198 |
| OXR1 | oxidation resistance 1 | -0.0356207 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0354825 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0352856 |
| USP34 | ubiquitin specific peptidase 34 | -0.0346036 |
| TNPO1 | transportin 1 | -0.0342417 |
| TMEM123 | transmembrane protein 123 | -0.0333663 |
| KLHL24 | kelch-like family member 24 | -0.033337 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0333006 |
| CBX3 | chromobox homolog 3 | -0.0332899 |
| TENM3 | teneurin transmembrane protein 3 | -0.033162 |
| KIF5B | kinesin family member 5B | -0.0331139 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0328695 |
| RPLP1 | ribosomal protein, large, P1 | -0.0326325 |
| TXNRD1 | thioredoxin reductase 1 | -0.0325936 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0325027 |
| YBX3 | Y box binding protein 3 | -0.0324845 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0308779 |
| NF1 | neurofibromin 1 | -0.0307427 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.030486 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0296736 |
| FTL | ferritin, light polypeptide | -0.0296418 |
| PCBP2 | poly(rC) binding protein 2 | -0.0292414 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.029209 |
| SETD5 | SET domain containing 5 | -0.0289306 |
| THOC2 | THO complex 2 | -0.0286962 |
| MATR3 | matrin 3 | -0.028691 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0285661 |
| MED13L | mediator complex subunit 13-like | -0.0284944 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0284219 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0282305 |
| WDR43 | WD repeat domain 43 | -0.0282214 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0281619 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0277579 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0277491 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0277044 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0275511 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0274959 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.027268 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.027206 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0271586 |
| RBM39 | RNA binding motif protein 39 | -0.0269736 |
| RBM25 | RNA binding motif protein 25 | -0.0268941 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0266952 |
| OGA | O-GlcNAcase | -0.0266719 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0265626 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0264246 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0262466 |
| CENPF | centromere protein F, 350/400kDa | -0.0260603 |
| GOLGA4 | golgin A4 | -0.026057 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0258329 |
| NKTR | natural killer cell triggering receptor | -0.0257338 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0256698 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0255818 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0255724 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0254256 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.02491 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0248286 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.02455 |
| ZNF207 | zinc finger protein 207 | -0.0244619 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0243747 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0242962 |
| RBM27 | RNA binding motif protein 27 | -0.0242376 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0238439 |
| CEP192 | centrosomal protein 192kDa | -0.0235683 |
| AXIN2 | axin 2 | -0.0234066 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0232162 |
| HELZ | helicase with zinc finger | -0.0231354 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.023082 |
| HLTF | helicase-like transcription factor | -0.0230504 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0230402 |
