| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.200613 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.118735 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.117267 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.107666 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0906451 |
| SMAD3 | SMAD family member 3 | 0.0891267 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0888263 |
| HLA-B | major histocompatibility complex, class I, B | 0.0874437 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0851271 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0837147 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0751834 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0736073 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0671802 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0660824 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0652963 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0640139 |
| ASPH | aspartate beta-hydroxylase | 0.0625815 |
| APP | amyloid beta (A4) precursor protein | 0.0616734 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0606347 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.060226 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0574109 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.057225 |
| LDHA | lactate dehydrogenase A | 0.0559832 |
| CTBP2 | C-terminal binding protein 2 | 0.055674 |
| RPL26 | ribosomal protein L26 | 0.0523776 |
| ARRDC3 | arrestin domain containing 3 | 0.0521103 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0507751 |
| RND3 | Rho family GTPase 3 | 0.0505186 |
| KYNU | kynureninase | 0.0497476 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0488122 |
| TLE4 | transducin-like enhancer of split 4 | 0.0478575 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0478091 |
| SEPTIN9 | septin 9 | 0.0471853 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0466606 |
| RPS8 | ribosomal protein S8 | 0.0466157 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0462653 |
| CD44 | CD44 molecule (Indian blood group) | 0.0459657 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0454789 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0452015 |
| ATF3 | activating transcription factor 3 | 0.044636 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0439605 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0438685 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0433408 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0426099 |
| JAK1 | Janus kinase 1 | 0.0416416 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0412121 |
| MT2A | metallothionein 2A | 0.0406966 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0400807 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0398406 |
| G0S2 | G0/G1 switch 2 | 0.0387947 |
| RNF213 | ring finger protein 213 | 0.0386581 |
| RPL23 | ribosomal protein L23 | 0.0375928 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.037453 |
| PTK2 | protein tyrosine kinase 2 | 0.0370391 |
| NAV2 | neuron navigator 2 | 0.0369459 |
| NRP2 | neuropilin 2 | 0.0364513 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0356345 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0353168 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0351317 |
| PDLIM5 | PDZ and LIM domain 5 | 0.034968 |
| FMNL2 | formin-like 2 | 0.0348856 |
| CRY1 | cryptochrome circadian clock 1 | 0.0346333 |
| FAT1 | FAT atypical cadherin 1 | 0.0345702 |
| MLF1 | myeloid leukemia factor 1 | 0.0344342 |
| RUNX1 | runt-related transcription factor 1 | 0.0340552 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0340313 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0336891 |
| KLF6 | Kruppel-like factor 6 | 0.0331177 |
| PLEC | plectin | 0.0327194 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0325049 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0321906 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0321394 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0318343 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0317037 |
| NCKAP1 | NCK-associated protein 1 | 0.0316491 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0312358 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.031106 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0311014 |
| MYO1E | myosin IE | 0.0310854 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.0309907 |
| RPS12 | ribosomal protein S12 | 0.0308914 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0306383 |
| FLNA | filamin A, alpha | 0.0304666 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0302499 |
| RPS2 | ribosomal protein S2 | 0.0302434 |
| RPL13A | ribosomal protein L13a | 0.0302326 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0302112 |
| PRKCG | protein kinase C, gamma | 0.0298329 |
| TPM3 | tropomyosin 3 | 0.0298081 |
| B2M | beta-2-microglobulin | 0.0295444 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0293222 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0292639 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.029219 |
| FAM13A | family with sequence similarity 13, member A | 0.0292029 |
| TUFT1 | tuftelin 1 | 0.0290681 |
| ANXA1 | annexin A1 | 0.0287606 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0283388 |
| MSN | moesin | 0.0271832 |
| DENND2B | DENN domain containing 2B | 0.0271826 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0271463 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.181783 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.146398 |
| FRMD4A | FERM domain containing 4A | -0.113642 |
| PLIN2 | perilipin 2 | -0.0852352 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0844376 |
| RRBP1 | ribosome binding protein 1 | -0.0796076 |
| GPC6 | glypican 6 | -0.0665577 |
| TMSB10 | thymosin beta 10 | -0.0657958 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0651269 |
| PKM | pyruvate kinase, muscle | -0.0644939 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0635632 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0622161 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0616864 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.059482 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0588294 |
| RAI14 | retinoic acid induced 14 | -0.0580705 |
| CP | ceruloplasmin (ferroxidase) | -0.0542565 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.051547 |
| DIAPH3 | diaphanous-related formin 3 | -0.0507453 |
| MAP1B | microtubule-associated protein 1B | -0.0504635 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0490648 |
| PTMA | prothymosin, alpha | -0.0465107 |
| FTL | ferritin, light polypeptide | -0.0462345 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.045004 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0447157 |
| CBX3 | chromobox homolog 3 | -0.04271 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0424147 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0412464 |
| RIGI | RNA sensor RIG-I | -0.0388151 |
| SCFD2 | sec1 family domain containing 2 | -0.0385803 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0363413 |
| CDK6 | cyclin-dependent kinase 6 | -0.0361432 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0358095 |
| CAVIN1 | caveolae associated protein 1 | -0.0356078 |
| RPS6 | ribosomal protein S6 | -0.0352505 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0351638 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0351 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.034387 |
| TPM4 | tropomyosin 4 | -0.0331259 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0328633 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0326319 |
| TUBA1B | tubulin, alpha 1b | -0.0325794 |
| CALD1 | caldesmon 1 | -0.0323146 |
| THOC2 | THO complex 2 | -0.0315603 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0314461 |
| GNAS | GNAS complex locus | -0.0314178 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0308378 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0307497 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0305346 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0302055 |
| TKT | transketolase | -0.0300985 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0300011 |
| CENPF | centromere protein F, 350/400kDa | -0.0297337 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0296176 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0296057 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0293392 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0292997 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0292784 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0289657 |
| SEPTIN7 | septin 7 | -0.0288334 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0287514 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0286903 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0284232 |
| TRAM1 | translocation associated membrane protein 1 | -0.0282083 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0279725 |
| FRMD5 | FERM domain containing 5 | -0.0278312 |
| ACLY | ATP citrate lyase | -0.0277678 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0277531 |
| CUX1 | cut-like homeobox 1 | -0.0277071 |
| UBXN4 | UBX domain protein 4 | -0.02769 |
| TPM1 | tropomyosin 1 (alpha) | -0.0276039 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0275208 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0275021 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0274737 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0272394 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0271936 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | -0.0271744 |
| ATM | ATM serine/threonine kinase | -0.0269166 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0267223 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0266327 |
| POTEF | POTE ankyrin domain family, member F | -0.0265056 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0264853 |
| MORF4L2 | mortality factor 4 like 2 | -0.0264223 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0262963 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0261244 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0259243 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0259035 |
| HDLBP | high density lipoprotein binding protein | -0.025618 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | -0.0256141 |
| RPS24 | ribosomal protein S24 | -0.0255066 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0254837 |
| UBAP2 | ubiquitin associated protein 2 | -0.0254508 |
| OXR1 | oxidation resistance 1 | -0.0251917 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0245731 |
| IFI44L | interferon-induced protein 44-like | -0.0244082 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0243266 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -0.0242921 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0242766 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0241789 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0237283 |
