| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.141635 |
| SMAD3 | SMAD family member 3 | 0.139643 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.116611 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.101322 |
| FAM107B | family with sequence similarity 107, member B | 0.0815517 |
| RPL26 | ribosomal protein L26 | 0.0800237 |
| EFNA5 | ephrin-A5 | 0.0760878 |
| FLNB | filamin B, beta | 0.0739764 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0734105 |
| MCL1 | myeloid cell leukemia 1 | 0.0716878 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0684846 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0667343 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0655436 |
| RPL13A | ribosomal protein L13a | 0.0653296 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0650218 |
| RPS12 | ribosomal protein S12 | 0.061464 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0599201 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0598293 |
| SMYD3 | SET and MYND domain containing 3 | 0.0590883 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0588645 |
| RPS3 | ribosomal protein S3 | 0.0581834 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0574728 |
| ACTG1 | actin gamma 1 | 0.0566067 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0563602 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0562618 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0536288 |
| RPL37A | ribosomal protein L37a | 0.0534768 |
| NAV2 | neuron navigator 2 | 0.0516468 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0490453 |
| MT2A | metallothionein 2A | 0.0484026 |
| RPL23 | ribosomal protein L23 | 0.0475608 |
| FMNL2 | formin-like 2 | 0.0462341 |
| RPS13 | ribosomal protein S13 | 0.0454414 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.044756 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0446598 |
| RUNX1 | runt-related transcription factor 1 | 0.044476 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0443706 |
| RPS2 | ribosomal protein S2 | 0.0433648 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.042325 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0418193 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0412229 |
| PRKCE | protein kinase C, epsilon | 0.0407427 |
| CTBP2 | C-terminal binding protein 2 | 0.040589 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0404482 |
| SQSTM1 | sequestosome 1 | 0.0392534 |
| RPS27A | ribosomal protein S27a | 0.0391835 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0388073 |
| RPL35A | ribosomal protein L35a | 0.0385536 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0382331 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0378032 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0377111 |
| RPS17 | ribosomal protein S17 | 0.0370679 |
| RAD51B | RAD51 paralog B | 0.0365018 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0363718 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.035739 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0356293 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0355639 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0354457 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0348853 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0348011 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0340695 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0340217 |
| INTS6 | integrator complex subunit 6 | 0.0339786 |
| ACTN4 | actinin, alpha 4 | 0.0330836 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0328929 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0323739 |
| RPS29 | ribosomal protein S29 | 0.0323679 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0323375 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0322126 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0319652 |
| DUSP5 | dual specificity phosphatase 5 | 0.031638 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0307291 |
| RPS23 | ribosomal protein S23 | 0.0307152 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0306151 |
| FLNA | filamin A, alpha | 0.0305922 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0298882 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0298307 |
| RPL7A | ribosomal protein L7a | 0.0297954 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0297714 |
| HSPA8 | heat shock 70kDa protein 8 | 0.028959 |
| RPL11 | ribosomal protein L11 | 0.0282941 |
| FA2H | fatty acid 2-hydroxylase | 0.0279605 |
| TNS1 | tensin 1 | 0.0279218 |
| SEPTIN9 | septin 9 | 0.0278286 |
| MSN | moesin | 0.0276619 |
| PRELID2 | PRELI domain containing 2 | 0.0276032 |
| HMGA1 | high mobility group AT-hook 1 | 0.0274256 |
| RPS25 | ribosomal protein S25 | 0.0267692 |
| POTEF | POTE ankyrin domain family, member F | 0.0265767 |
| DENND1A | DENN/MADD domain containing 1A | 0.0262061 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0256571 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0255283 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0253807 |
| RPS8 | ribosomal protein S8 | 0.0253772 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0246443 |
| RPL37 | ribosomal protein L37 | 0.0245401 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0244141 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0243193 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0242998 |
| WWOX | WW domain containing oxidoreductase | 0.0240822 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.159536 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.138739 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.130924 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.128515 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.098835 |
| TMSB10 | thymosin beta 10 | -0.0945937 |
| KYNU | kynureninase | -0.0911196 |
| VCL | vinculin | -0.0902551 |
| FTL | ferritin, light polypeptide | -0.0835264 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0725548 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0715653 |
| RPLP1 | ribosomal protein, large, P1 | -0.0675404 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0655472 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0651748 |
| OSMR | oncostatin M receptor | -0.0631218 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0616924 |
| PTMA | prothymosin, alpha | -0.0616518 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0599804 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0569669 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0549598 |
| TXNRD1 | thioredoxin reductase 1 | -0.0538677 |
| RRBP1 | ribosome binding protein 1 | -0.0535962 |
| RNF213 | ring finger protein 213 | -0.0513816 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0510555 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0503552 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0501081 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0491253 |
| RPS6 | ribosomal protein S6 | -0.0454198 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0451086 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0450236 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0442024 |
| TPM1 | tropomyosin 1 (alpha) | -0.0393331 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0392842 |
| TPM4 | tropomyosin 4 | -0.0389151 |
| CANX | calnexin | -0.0385541 |
| S100A6 | S100 calcium binding protein A6 | -0.0379389 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0373404 |
| EHBP1 | EH domain binding protein 1 | -0.0361943 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0359303 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0348523 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0344367 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0337834 |
| TKT | transketolase | -0.0337084 |
| PALLD | palladin, cytoskeletal associated protein | -0.0323881 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0320503 |
| BICC1 | BicC family RNA binding protein 1 | -0.0317369 |
| PKM | pyruvate kinase, muscle | -0.0317187 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0314512 |
| CA12 | carbonic anhydrase XII | -0.0314312 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0313703 |
| MAP1B | microtubule-associated protein 1B | -0.031367 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.03133 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0312294 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0300782 |
| RSPO3 | R-spondin 3 | -0.0299366 |
| CALD1 | caldesmon 1 | -0.0298553 |
| NTN4 | netrin 4 | -0.0286996 |
| COL5A2 | collagen, type V, alpha 2 | -0.0286901 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0285191 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0284076 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0283615 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0283564 |
| ABLIM1 | actin binding LIM protein 1 | -0.0281761 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0277944 |
| KRT7 | keratin 7, type II | -0.0272846 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0272754 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0268136 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0267243 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.026674 |
| GOLGA4 | golgin A4 | -0.0266235 |
| TNS3 | tensin 3 | -0.0261713 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0261683 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0259733 |
| RIN2 | Ras and Rab interactor 2 | -0.0259442 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0259126 |
| ITGAV | integrin, alpha V | -0.0256759 |
| NRG1 | neuregulin 1 | -0.0249247 |
| SP100 | SP100 nuclear antigen | -0.0249187 |
| DST | dystonin | -0.0248229 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0246 |
| RIGI | RNA sensor RIG-I | -0.0245459 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0244375 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0236564 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0231602 |
| THOC2 | THO complex 2 | -0.0229826 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0229302 |
| TMSB4X | thymosin beta 4, X-linked | -0.0228591 |
| NRP1 | neuropilin 1 | -0.0228008 |
| TRAM1 | translocation associated membrane protein 1 | -0.0227958 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0227715 |
| MYOF | myoferlin | -0.022763 |
| EREG | epiregulin | -0.0226876 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0225876 |
| GPRIN3 | GPRIN family member 3 | -0.022388 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0223349 |
| PGK1 | phosphoglycerate kinase 1 | -0.0223271 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0220248 |
| RBM25 | RNA binding motif protein 25 | -0.0219804 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0218722 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0217691 |
