Lapatinib ditosylate_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.21945
TPT1 tumor protein, translationally-controlled 1 0.0779174
RPL37A ribosomal protein L37a 0.0776371
ACTG1 actin gamma 1 0.076206
RPS12 ribosomal protein S12 0.0760393
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0741827
RPL13A ribosomal protein L13a 0.0718681
RPS8 ribosomal protein S8 0.0709269
HMGA1 high mobility group AT-hook 1 0.0637323
PDE4D phosphodiesterase 4D, cAMP-specific 0.0567707
RPL26 ribosomal protein L26 0.0561152
TSHZ2 teashirt zinc finger homeobox 2 0.0551765
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0517879
PDE10A phosphodiesterase 10A 0.0516069
RPL23 ribosomal protein L23 0.0502231
RPL5 ribosomal protein L5 0.0499585
MT2A metallothionein 2A 0.049803
RPL35A ribosomal protein L35a 0.0495289
RPS3 ribosomal protein S3 0.0476655
RPS13 ribosomal protein S13 0.0475708
RPS2 ribosomal protein S2 0.0472884
LINGO2 leucine rich repeat and Ig domain containing 2 0.0455071
RPS23 ribosomal protein S23 0.0454664
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0447824
HSPA8 heat shock 70kDa protein 8 0.0441243
RPS27A ribosomal protein S27a 0.0439295
GSE1 Gse1 coiled-coil protein 0.0436828
RPS6 ribosomal protein S6 0.04138
ENO1 enolase 1, (alpha) 0.0413423
RPS25 ribosomal protein S25 0.040134
RPL36 ribosomal protein L36 0.0389652
EGFR epidermal growth factor receptor 0.0359319
RPL38 ribosomal protein L38 0.0334998
DOCK3 dedicator of cytokinesis 3 0.0332967
RPS17 ribosomal protein S17 0.0330168
RPL6 ribosomal protein L6 0.0329264
RPL37 ribosomal protein L37 0.0324317
IGF2 insulin-like growth factor 2 0.0316718
RPS29 ribosomal protein S29 0.0310244
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.030228
RPS15 ribosomal protein S15 0.0297055
RPLP2 ribosomal protein, large, P2 0.029657
EGR1 early growth response 1 0.0293484
HMGA2 high mobility group AT-hook 2 0.0291292
INTS6 integrator complex subunit 6 0.0290694
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0288027
RPL7A ribosomal protein L7a 0.0283276
RPL11 ribosomal protein L11 0.0282997
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0280113
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0274738
SPRY4 sprouty homolog 4 (Drosophila) 0.0271826
RACK1 receptor for activated C kinase 1 0.026765
RAD51B RAD51 paralog B 0.0266017
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0265655
GLI2 GLI family zinc finger 2 0.0262948
IGFBP3 insulin-like growth factor binding protein 3 0.0262375
PSD3 pleckstrin and Sec7 domain containing 3 0.0259162
RPS14 ribosomal protein S14 0.0257223
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0256665
RPS10 ribosomal protein S10 0.0256471
DSCAM Down syndrome cell adhesion molecule 0.0255088
LGALS12 lectin, galactoside-binding, soluble, 12 0.025163
GANAB glucosidase, alpha; neutral AB 0.0251579
ATP11A ATPase, class VI, type 11A 0.0248962
RPL7 ribosomal protein L7 0.0248622
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0248002
FNDC3B fibronectin type III domain containing 3B 0.0245935
FTH1 ferritin, heavy polypeptide 1 0.0244024
GPC6 glypican 6 0.0243195
CUX1 cut-like homeobox 1 0.024023
PCDH7 protocadherin 7 0.0239768
RPL36A ribosomal protein L36a 0.0235997
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0230826
CREM cAMP responsive element modulator 0.0228291
TAOK1 TAO kinase 1 0.022716
FNIP1 folliculin interacting protein 1 0.0225168
HIPK2 homeodomain interacting protein kinase 2 0.0219236
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0219135
MSRB3 methionine sulfoxide reductase B3 0.0218998
RPS27 ribosomal protein S27 0.0218607
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218458
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0216682
RPL27 ribosomal protein L27 0.0216178
HLA-B major histocompatibility complex, class I, B 0.0213616
NACA nascent polypeptide-associated complex alpha subunit 0.0213131
SMAD3 SMAD family member 3 0.0210943
SFPQ splicing factor proline/glutamine-rich 0.0210636
SIK3 SIK family kinase 3 0.020743
KTN1 kinectin 1 (kinesin receptor) 0.0207385
CD63 CD63 molecule 0.0207171
RPL31 ribosomal protein L31 0.0206608
SET SET nuclear proto-oncogene 0.0205463
RPL9 ribosomal protein L9 0.0203425
KDM5C lysine (K)-specific demethylase 5C 0.0202413
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0200964
WNK1 WNK lysine deficient protein kinase 1 0.0199873
SMYD3 SET and MYND domain containing 3 0.0198298
RABGAP1L RAB GTPase activating protein 1-like 0.0197487
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0196869
TPM3 tropomyosin 3 0.0193338

decreased expression

Symbol Name Standardized Value
NFIB nuclear factor I/B -0.0891848
SOX4 SRY (sex determining region Y)-box 4 -0.076446
QKI QKI, KH domain containing, RNA binding -0.065068
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0634132
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0605987
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0601241
COL1A2 collagen, type I, alpha 2 -0.0573928
KMT2C lysine (K)-specific methyltransferase 2C -0.0512086
ZFAND3 zinc finger, AN1-type domain 3 -0.0483942
MEOX2 mesenchyme homeobox 2 -0.0480435
PTMA prothymosin, alpha -0.0472291
MATR3 matrin 3 -0.0467437
TET1 tet methylcytosine dioxygenase 1 -0.046711
NFIA nuclear factor I/A -0.0464516
PEG10 paternally expressed 10 -0.0447811
KDM5B lysine (K)-specific demethylase 5B -0.0442679
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0440897
SBF2 SET binding factor 2 -0.0425706
TUT4 terminal uridylyl transferase 4 -0.0423728
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0421542
PCM1 pericentriolar material 1 -0.0417581
ZNF292 zinc finger protein 292 -0.0411543
CENPF centromere protein F, 350/400kDa -0.0409786
TUBB tubulin, beta class I -0.0409748
TPK1 thiamin pyrophosphokinase 1 -0.0405805
RNF145 ring finger protein 145 -0.0398611
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0394829
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0393602
GOLGA4 golgin A4 -0.0384712
JMJD1C jumonji domain containing 1C -0.0383502
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0383481
PDGFC platelet derived growth factor C -0.0382955
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0382102
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0378562
NIPBL Nipped-B homolog (Drosophila) -0.037641
RPS4X ribosomal protein S4, X-linked -0.0374929
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0366296
SRRM2 serine/arginine repetitive matrix 2 -0.0363206
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0354233
XPO1 exportin 1 -0.0352629
HDLBP high density lipoprotein binding protein -0.0348703
RB1CC1 RB1-inducible coiled-coil 1 -0.0339303
AFF4 AF4/FMR2 family, member 4 -0.0333379
GLS2 glutaminase 2 (liver, mitochondrial) -0.0333018
FGFR2 fibroblast growth factor receptor 2 -0.0328544
TTC3 tetratricopeptide repeat domain 3 -0.0328344
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.0327409
RNF130 ring finger protein 130 -0.0327267
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0326805
RLF rearranged L-myc fusion -0.032667
NPEPPS aminopeptidase puromycin sensitive -0.0325993
CBX3 chromobox homolog 3 -0.0323763
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -0.0320628
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -0.0316479
FBXO11 F-box protein 11 -0.031559
NF1 neurofibromin 1 -0.0312406
OLA1 Obg-like ATPase 1 -0.0308003
TM9SF3 transmembrane 9 superfamily member 3 -0.0306862
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0306118
HELZ helicase with zinc finger -0.0305476
SNX13 sorting nexin 13 -0.0304218
TMSB10 thymosin beta 10 -0.0302645
SUCO SUN domain containing ossification factor -0.0302322
KLHL24 kelch-like family member 24 -0.029987
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0296429
CANX calnexin -0.0295264
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0293992
RSF1 remodeling and spacing factor 1 -0.0293966
KMT2E lysine (K)-specific methyltransferase 2E -0.0292777
HBP1 HMG-box transcription factor 1 -0.029206
SFTPA2 surfactant protein A2 -0.0290637
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0286975
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0284245
NEK7 NIMA-related kinase 7 -0.0281239
PRKG1 protein kinase, cGMP-dependent, type I -0.0280782
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.027735
CLINT1 clathrin interactor 1 -0.027709
CADM2 cell adhesion molecule 2 -0.0276332
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0275555
GARS1 glycyl-tRNA synthetase 1 -0.0275367
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0274565
CSDE1 cold shock domain containing E1, RNA-binding -0.0271897
ZMYM2 zinc finger, MYM-type 2 -0.0266823
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0266751
MTUS1 microtubule associated tumor suppressor 1 -0.0265436
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.026458
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0264422
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0263252
PHIP pleckstrin homology domain interacting protein -0.0263187
ARHGAP21 Rho GTPase activating protein 21 -0.026205
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0261593
CHD9 chromodomain helicase DNA binding protein 9 -0.0260004
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0256376
RBM25 RNA binding motif protein 25 -0.0254948
PIAS2 protein inhibitor of activated STAT, 2 -0.0254816
AKAP10 A kinase (PRKA) anchor protein 10 -0.0254434
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0251584
MARCHF6 membrane associated ring-CH-type finger 6 -0.0251465
TOP2B topoisomerase (DNA) II beta 180kDa -0.0250847
PHF3 PHD finger protein 3 -0.0250415