| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.258878 |
| LAMB3 | laminin, beta 3 | 0.156419 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.141698 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.113924 |
| EGFR | epidermal growth factor receptor | 0.107485 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0983921 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0885959 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.0882931 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0879482 |
| SMAD3 | SMAD family member 3 | 0.0869439 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0844012 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0832623 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0829292 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0810737 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0807806 |
| MCL1 | myeloid cell leukemia 1 | 0.0807803 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0801374 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0774722 |
| EFNA5 | ephrin-A5 | 0.0770921 |
| PARD3 | par-3 family cell polarity regulator | 0.0716756 |
| PLEC | plectin | 0.0705874 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0691035 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0676428 |
| TXNRD1 | thioredoxin reductase 1 | 0.0669468 |
| MXD1 | MAX dimerization protein 1 | 0.0641985 |
| SGMS2 | sphingomyelin synthase 2 | 0.0612071 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | 0.060988 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0590324 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0580807 |
| FMNL2 | formin-like 2 | 0.0550787 |
| FLNB | filamin B, beta | 0.0548545 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0493391 |
| LAMC2 | laminin, gamma 2 | 0.0491633 |
| TPM3 | tropomyosin 3 | 0.0487002 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0481514 |
| PMM2 | phosphomannomutase 2 | 0.0473383 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0469899 |
| CLMP | CXADR-like membrane protein | 0.0462939 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0462306 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0460283 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0444126 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.0434771 |
| SIK3 | SIK family kinase 3 | 0.0433407 |
| HMGA1 | high mobility group AT-hook 1 | 0.0432044 |
| SEPTIN9 | septin 9 | 0.0417565 |
| RPL26 | ribosomal protein L26 | 0.0414727 |
| BMP6 | bone morphogenetic protein 6 | 0.0412546 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0412358 |
| TRRAP | transformation/transcription domain-associated protein | 0.0405935 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.040107 |
| KLK10 | kallikrein-related peptidase 10 | 0.039969 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0393983 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0393235 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0389598 |
| CALU | calumenin | 0.0371135 |
| RPL37A | ribosomal protein L37a | 0.0371034 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.037087 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.036953 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0369462 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0367992 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0365341 |
| UBC | ubiquitin C | 0.0348754 |
| MMP1 | matrix metallopeptidase 1 | 0.0342124 |
| TGM2 | transglutaminase 2 | 0.0340707 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0337967 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0336054 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0332287 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0328948 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0324687 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0320006 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0317112 |
| ACTN4 | actinin, alpha 4 | 0.0315291 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0314728 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0314285 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.0313345 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0309861 |
| RUNX1 | runt-related transcription factor 1 | 0.03044 |
| EGR1 | early growth response 1 | 0.0302965 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0293786 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0291344 |
| B2M | beta-2-microglobulin | 0.0291053 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0290368 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0288049 |
| RPS8 | ribosomal protein S8 | 0.028746 |
| RPS12 | ribosomal protein S12 | 0.0284256 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0283682 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0282001 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0281735 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0281146 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0280654 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0279263 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0276889 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.027499 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0274684 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.0273675 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0271842 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0271569 |
| HM13 | histocompatibility (minor) 13 | 0.026861 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0266694 |
| APP | amyloid beta (A4) precursor protein | 0.0265299 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.140613 |
| PTMA | prothymosin, alpha | -0.106447 |
| POTEF | POTE ankyrin domain family, member F | -0.0789335 |
| ITGA6 | integrin, alpha 6 | -0.0720355 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0664981 |
| S100A10 | S100 calcium binding protein A10 | -0.0646697 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0578739 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0552703 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0536585 |
| TSC22D2 | TSC22 domain family, member 2 | -0.045695 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.044188 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0431732 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0420868 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0419171 |
| S100A4 | S100 calcium binding protein A4 | -0.0414324 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0409908 |
| MYOF | myoferlin | -0.0404308 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0401758 |
| PERP | PERP, TP53 apoptosis effector | -0.040045 |
| NPSR1 | neuropeptide S receptor 1 | -0.0397415 |
| VCAN | versican | -0.0371733 |
| WASF2 | WAS protein family, member 2 | -0.035898 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0353056 |
| LMO7 | LIM domain 7 | -0.0317059 |
| ANLN | anillin, actin binding protein | -0.0314364 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0300951 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0298084 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0284426 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0283688 |
| RPLP1 | ribosomal protein, large, P1 | -0.028016 |
| MUC17 | mucin 17, cell surface associated | -0.0277508 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0277145 |
| RBM25 | RNA binding motif protein 25 | -0.0272789 |
| ITGB4 | integrin, beta 4 | -0.0266263 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0263263 |
| CCDC88A | coiled-coil domain containing 88A | -0.0257222 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0256566 |
| VIM | vimentin | -0.0254308 |
| SEPTIN7 | septin 7 | -0.0253021 |
| CD2AP | CD2-associated protein | -0.0251823 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.02488 |
| PKM | pyruvate kinase, muscle | -0.0243183 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0242575 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0240128 |
| JUP | junction plakoglobin | -0.0238061 |
| LIMA1 | LIM domain and actin binding 1 | -0.0233692 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0232669 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0227605 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0223587 |
| ZNF292 | zinc finger protein 292 | -0.0221738 |
| VCL | vinculin | -0.0219349 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0210322 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0209392 |
| TOP1 | topoisomerase (DNA) I | -0.0208899 |
| ACTG1 | actin gamma 1 | -0.0208426 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.0203365 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0202946 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0202436 |
| LYZ | lysozyme | -0.0201464 |
| CCNL1 | cyclin L1 | -0.0200909 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0199972 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0198745 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0198697 |
| RTN4 | reticulon 4 | -0.0197277 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | -0.0196624 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0195799 |
| S100A6 | S100 calcium binding protein A6 | -0.0194313 |
| SLMAP | sarcolemma associated protein | -0.0190442 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0188065 |
| MKI67 | marker of proliferation Ki-67 | -0.0187572 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0187533 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | -0.0185713 |
| XPO1 | exportin 1 | -0.0182505 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.0181967 |
| TMEM165 | transmembrane protein 165 | -0.0180287 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0176996 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0176775 |
| CDC42SE2 | CDC42 small effector 2 | -0.0175535 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0175505 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0174909 |
| GOLGA4 | golgin A4 | -0.0174812 |
| GNAS | GNAS complex locus | -0.0174626 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0171633 |
| USP3 | ubiquitin specific peptidase 3 | -0.0170641 |
| NEK7 | NIMA-related kinase 7 | -0.0169432 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0167347 |
| APAF1 | apoptotic peptidase activating factor 1 | -0.0167237 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0166995 |
| RPS4X | ribosomal protein S4, X-linked | -0.0166721 |
| RIOK3 | RIO kinase 3 | -0.0166627 |
| CSTB | cystatin B (stefin B) | -0.0166528 |
| CENPF | centromere protein F, 350/400kDa | -0.0165237 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0164955 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0164571 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.016449 |
| EPCAM | epithelial cell adhesion molecule | -0.0164071 |
| RPS6 | ribosomal protein S6 | -0.0161439 |
| PLAC8 | placenta-specific 8 | -0.016128 |
| THOC2 | THO complex 2 | -0.0160886 |
| RSF1 | remodeling and spacing factor 1 | -0.0159955 |
