Lapatinib ditosylate_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.241238
RPL19 ribosomal protein L19 0.135331
TENM2 teneurin transmembrane protein 2 0.134592
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.12278
RPS3 ribosomal protein S3 0.0919028
PBX1 pre-B-cell leukemia homeobox 1 0.0905542
VMP1 vacuole membrane protein 1 0.0807311
IFI6 interferon, alpha-inducible protein 6 0.0750886
FBXL20 F-box and leucine-rich repeat protein 20 0.068834
PTMA prothymosin, alpha 0.0590154
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0572533
MT2A metallothionein 2A 0.0571787
PAWR PRKC, apoptosis, WT1, regulator 0.0563057
VCL vinculin 0.0544749
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0529986
TPT1 tumor protein, translationally-controlled 1 0.050024
ENAH enabled homolog (Drosophila) 0.0488282
AKAP9 A kinase (PRKA) anchor protein 9 0.0482105
RPS29 ribosomal protein S29 0.0466792
FOXO3 forkhead box O3 0.0466137
ZFP36L1 ZFP36 ring finger protein-like 1 0.0465555
SAMD12 sterile alpha motif domain containing 12 0.0459964
MYH9 myosin, heavy chain 9, non-muscle 0.0459702
RPL35A ribosomal protein L35a 0.0445304
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0439694
MCL1 myeloid cell leukemia 1 0.0434347
RPL37A ribosomal protein L37a 0.0419018
PRLR prolactin receptor 0.0415138
LOC102724023 ES1 protein homolog, mitochondrial 0.0404165
NUPR1 nuclear protein, transcriptional regulator, 1 0.0398734
BCAS3 breast carcinoma amplified sequence 3 0.0394739
HLA-B major histocompatibility complex, class I, B 0.0394241
ACTG1 actin gamma 1 0.0391592
PGM2L1 phosphoglucomutase 2-like 1 0.0378646
NEBL nebulette 0.0377852
GRB7 growth factor receptor-bound protein 7 0.0375812
KIAA1217 KIAA1217 0.0373323
ZBTB20 zinc finger and BTB domain containing 20 0.0362319
PDLIM5 PDZ and LIM domain 5 0.0357235
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.035512
B2M beta-2-microglobulin 0.0354166
PTPRK protein tyrosine phosphatase, receptor type, K 0.0353068
RPS12 ribosomal protein S12 0.0350646
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0341664
RPS8 ribosomal protein S8 0.0339183
CSNK1A1 casein kinase 1, alpha 1 0.0336264
UNC13B unc-13 homolog B (C. elegans) 0.0334731
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0330969
FGF13 fibroblast growth factor 13 0.0329731
ALCAM activated leukocyte cell adhesion molecule 0.0315507
FOXN3 forkhead box N3 0.0313745
RPL26 ribosomal protein L26 0.0301058
RPL12 ribosomal protein L12 0.0300251
HLA-C major histocompatibility complex, class I, C 0.0296433
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0294664
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0293239
RAD51B RAD51 paralog B 0.0288975
ESRRG estrogen-related receptor gamma 0.0286383
RPL37 ribosomal protein L37 0.0286209
FTL ferritin, light polypeptide 0.0282159
SLFN5 schlafen family member 5 0.0281118
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0280639
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0275356
RPS19 ribosomal protein S19 0.0274514
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0273137
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.0273083
RPL9 ribosomal protein L9 0.0270708
VEGFA vascular endothelial growth factor A 0.0270075
RPL13A ribosomal protein L13a 0.0268938
RPS27A ribosomal protein S27a 0.0260205
VTCN1 V-set domain containing T cell activation inhibitor 1 0.0252581
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0251893
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0248801
CCDC6 coiled-coil domain containing 6 0.0247101
RPS13 ribosomal protein S13 0.0246347
WSB1 WD repeat and SOCS box containing 1 0.0246014
ACTN4 actinin, alpha 4 0.0243573
RAB7A RAB7A, member RAS oncogene family 0.0241566
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0239777
INTS6 integrator complex subunit 6 0.0239548
RPS27 ribosomal protein S27 0.0238382
HMGB2 high mobility group box 2 0.0237982
VAV3 vav 3 guanine nucleotide exchange factor 0.0237198
RBM47 RNA binding motif protein 47 0.0229353
RPL36 ribosomal protein L36 0.0226417
ZSWIM6 zinc finger, SWIM-type containing 6 0.0224863
RPS2 ribosomal protein S2 0.0224247
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0223192
RPS6 ribosomal protein S6 0.0219847
CEP250 centrosomal protein 250kDa 0.0217905
RPL7A ribosomal protein L7a 0.0217893
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0216177
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0215699
ANKRD12 ankyrin repeat domain 12 0.0214884
RPS17 ribosomal protein S17 0.0214567
KMT2E lysine (K)-specific methyltransferase 2E 0.0214378
MIEN1 migration and invasion enhancer 1 0.0214218
RPL11 ribosomal protein L11 0.0213175
SP100 SP100 nuclear antigen 0.0212388
SET SET nuclear proto-oncogene 0.0212098

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.139659
THSD4 thrombospondin, type I, domain containing 4 -0.109118
ZMYND8 zinc finger, MYND-type containing 8 -0.104901
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0931825
ACACA acetyl-CoA carboxylase alpha -0.0702389
CATSPERB catsper channel auxiliary subunit beta -0.0649999
CCND1 cyclin D1 -0.0640372
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0640282
ANKRD36C ankyrin repeat domain 36C -0.0633377
SMYD3 SET and MYND domain containing 3 -0.0617145
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0608739
CLTC clathrin, heavy chain (Hc) -0.0543152
CEMIP cell migration inducing protein, hyaluronan binding -0.052443
BZW1 basic leucine zipper and W2 domains 1 -0.0427647
OSMR oncostatin M receptor -0.0410961
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0407309
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0402763
MYOF myoferlin -0.0402409
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0399032
TRIO trio Rho guanine nucleotide exchange factor -0.0378134
FNDC3B fibronectin type III domain containing 3B -0.037306
TNIK TRAF2 and NCK interacting kinase -0.0366043
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.034441
ITGB6 integrin, beta 6 -0.0342487
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0339756
TMSB4X thymosin beta 4, X-linked -0.0320479
SRCIN1 SRC kinase signaling inhibitor 1 -0.0316545
NF1 neurofibromin 1 -0.0313007
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0308398
AHNAK AHNAK nucleoprotein -0.0305114
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0304538
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0295939
ANXA2 annexin A2 -0.0294636
ZFAND3 zinc finger, AN1-type domain 3 -0.0292421
AGO2 argonaute RISC catalytic component 2 -0.0287596
RIMS2 regulating synaptic membrane exocytosis 2 -0.0287171
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0285819
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0284438
RESF1 retroelement silencing factor 1 -0.0283003
MYO6 myosin VI -0.0274526
GMDS GDP-mannose 4,6-dehydratase -0.0256561
PTK2 protein tyrosine kinase 2 -0.0247443
IGFBP5 insulin-like growth factor binding protein 5 -0.0247339
LIMCH1 LIM and calponin homology domains 1 -0.0246328
LMAN1 lectin, mannose-binding, 1 -0.0246235
TMEM45B transmembrane protein 45B -0.0245876
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0245605
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0244369
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0244232
ZC3H11A zinc finger CCCH-type containing 11A -0.0244135
DSG2 desmoglein 2 -0.0242622
SBF2 SET binding factor 2 -0.0240552
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0239798
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0239363
UGCG UDP-glucose ceramide glucosyltransferase -0.0236913
TMEM123 transmembrane protein 123 -0.0236539
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0235596
MYO5B myosin VB -0.023414
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0233024
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0232518
RAI14 retinoic acid induced 14 -0.0228491
TNS3 tensin 3 -0.0227977
HDLBP high density lipoprotein binding protein -0.022729
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0226708
ARHGAP32 Rho GTPase activating protein 32 -0.0223349
SYTL2 synaptotagmin-like 2 -0.0223029
TMEM165 transmembrane protein 165 -0.0222833
DENND1A DENN/MADD domain containing 1A -0.0221579
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0220073
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0213986
TMC5 transmembrane channel-like 5 -0.0211955
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0207392
LDHA lactate dehydrogenase A -0.0197786
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0197653
TSC22D2 TSC22 domain family, member 2 -0.0195915
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0192851
TRAPPC9 trafficking protein particle complex 9 -0.0192701
RAB22A RAB22A, member RAS oncogene family -0.0190987
SLMAP sarcolemma associated protein -0.0190086
SAMD5 sterile alpha motif domain containing 5 -0.0188543
IPO7 importin 7 -0.0188485
SOD2 superoxide dismutase 2, mitochondrial -0.0188352
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0188174
DLG1 discs, large homolog 1 (Drosophila) -0.0187817
APP amyloid beta (A4) precursor protein -0.0185758
DUSP4 dual specificity phosphatase 4 -0.018527
SDC4 syndecan 4 -0.018396
KRT18 keratin 18, type I -0.0181544
MIPOL1 mirror-image polydactyly 1 -0.018134
FTH1 ferritin, heavy polypeptide 1 -0.0180871
DST dystonin -0.017936
IQGAP1 IQ motif containing GTPase activating protein 1 -0.01792
TUBB tubulin, beta class I -0.0177517
PGK1 phosphoglycerate kinase 1 -0.0177014
ZNF217 zinc finger protein 217 -0.0174153
PARD3 par-3 family cell polarity regulator -0.0172118
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0171343
MAP4 microtubule-associated protein 4 -0.0171289
TES testin LIM domain protein -0.0170579
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0169944