| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | 0.173332 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.148686 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.126766 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.116745 |
| ASPH | aspartate beta-hydroxylase | 0.0964353 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0944331 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0861925 |
| PRELID2 | PRELI domain containing 2 | 0.0759017 |
| SETBP1 | SET binding protein 1 | 0.074732 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0689754 |
| EXOC4 | exocyst complex component 4 | 0.0652298 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0633452 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0593729 |
| ATXN1 | ataxin 1 | 0.0574112 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.054355 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0538004 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0529487 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0520873 |
| NAV1 | neuron navigator 1 | 0.05153 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0506263 |
| SEPTIN9 | septin 9 | 0.0487517 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0485554 |
| INTS6 | integrator complex subunit 6 | 0.0484972 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0476545 |
| MT2A | metallothionein 2A | 0.0465548 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0451643 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0443012 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0440374 |
| PARVB | parvin, beta | 0.0438163 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.042165 |
| SMYD3 | SET and MYND domain containing 3 | 0.041874 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0408857 |
| PAX3 | paired box 3 | 0.0406206 |
| RASA3 | RAS p21 protein activator 3 | 0.0401112 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0398796 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0394391 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0392586 |
| ACTG1 | actin gamma 1 | 0.0389872 |
| EGR1 | early growth response 1 | 0.0388365 |
| NAV2 | neuron navigator 2 | 0.0384723 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0378241 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0365754 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0358144 |
| TLE4 | transducin-like enhancer of split 4 | 0.0354225 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0353631 |
| PCDH7 | protocadherin 7 | 0.0348646 |
| LRRC23 | leucine rich repeat containing 23 | 0.0343302 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0340679 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0335291 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0331022 |
| FMNL2 | formin-like 2 | 0.0330326 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0318877 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0316847 |
| RPS12 | ribosomal protein S12 | 0.0312483 |
| ACTN1 | actinin, alpha 1 | 0.0310498 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.030602 |
| RPL37A | ribosomal protein L37a | 0.0303983 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0296269 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0295454 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0295333 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0292775 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0291679 |
| TMEM255B | transmembrane protein 255B | 0.0284912 |
| TEX14 | testis expressed 14 | 0.0282072 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0276902 |
| FRMD4A | FERM domain containing 4A | 0.0276425 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0275901 |
| RPS8 | ribosomal protein S8 | 0.0272328 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0269243 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0267697 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0267388 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0260349 |
| CTTNBP2 | cortactin binding protein 2 | 0.025683 |
| GANAB | glucosidase, alpha; neutral AB | 0.0253539 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0253109 |
| RPS3 | ribosomal protein S3 | 0.0252204 |
| MFSD12 | major facilitator superfamily domain containing 12 | 0.0250147 |
| HMGA1 | high mobility group AT-hook 1 | 0.0244525 |
| PRKCE | protein kinase C, epsilon | 0.0241632 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0239869 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0238715 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.0238135 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0237006 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0236377 |
| MYO1E | myosin IE | 0.0236051 |
| SKI | SKI proto-oncogene | 0.0234946 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0232708 |
| HLA-B | major histocompatibility complex, class I, B | 0.0230401 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0229301 |
| BAIAP2 | BAI1-associated protein 2 | 0.0228945 |
| KIAA1549L | KIAA1549-like | 0.0227469 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0226629 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0226566 |
| DST | dystonin | 0.0225675 |
| FLNA | filamin A, alpha | 0.0225276 |
| EFR3B | EFR3 homolog B (S. cerevisiae) | 0.0225038 |
| ANXA2 | annexin A2 | 0.02249 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0223793 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0223298 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0222845 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.203396 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.167424 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.118132 |
| VIM | vimentin | -0.114412 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.10819 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0937857 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.086447 |
| GDF15 | growth differentiation factor 15 | -0.0804947 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0800007 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0709139 |
| RNF145 | ring finger protein 145 | -0.0682847 |
| DCT | dopachrome tautomerase | -0.0663138 |
| COPA | coatomer protein complex, subunit alpha | -0.0662083 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0646599 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0604767 |
| CDC73 | cell division cycle 73 | -0.0589703 |
| TAGLN2 | transgelin 2 | -0.0582223 |
| PTMA | prothymosin, alpha | -0.0564821 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0561552 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0556748 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0555008 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0540389 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0540329 |
| S100A6 | S100 calcium binding protein A6 | -0.0538198 |
| TMSB10 | thymosin beta 10 | -0.0522679 |
| AHR | aryl hydrocarbon receptor | -0.0494725 |
| PKM | pyruvate kinase, muscle | -0.0488859 |
| PGK1 | phosphoglycerate kinase 1 | -0.0487719 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0477714 |
| CALD1 | caldesmon 1 | -0.0474873 |
| PLIN2 | perilipin 2 | -0.0467859 |
| NBAS | neuroblastoma amplified sequence | -0.0459963 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0452375 |
| SRPK2 | SRSF protein kinase 2 | -0.0445387 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0436404 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0434733 |
| HELZ | helicase with zinc finger | -0.0433644 |
| SETD5 | SET domain containing 5 | -0.0425397 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0412866 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0409929 |
| TMEM123 | transmembrane protein 123 | -0.0389931 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0386644 |
| WDR45B | WD repeat domain 45B | -0.0380767 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0380373 |
| GNAS | GNAS complex locus | -0.0379662 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0379559 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0376909 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0373963 |
| VGF | VGF nerve growth factor inducible | -0.0371823 |
| GOLGA4 | golgin A4 | -0.0369951 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0368939 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0361012 |
| PRKD1 | protein kinase D1 | -0.0359643 |
| OXR1 | oxidation resistance 1 | -0.0353881 |
| INSIG2 | insulin induced gene 2 | -0.0352197 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.034878 |
| NPR2 | natriuretic peptide receptor 2 | -0.0348573 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0348253 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0348103 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0334596 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0332478 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0322622 |
| LAMB1 | laminin, beta 1 | -0.0321732 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0320564 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0320304 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.031849 |
| RBM39 | RNA binding motif protein 39 | -0.0317754 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0316714 |
| RNF24 | ring finger protein 24 | -0.0315399 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0310791 |
| ZC3H7A | zinc finger CCCH-type containing 7A | -0.0301835 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0299505 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0292877 |
| PTMS | parathymosin | -0.0290389 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0288442 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.028843 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0285841 |
| CCNL1 | cyclin L1 | -0.0283423 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0281535 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.027874 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0277886 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.0277529 |
| TFG | TRK-fused gene | -0.0276699 |
| CALU | calumenin | -0.0274029 |
| UBC | ubiquitin C | -0.0270135 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0268932 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0268776 |
| HMCN1 | hemicentin 1 | -0.026778 |
| RIOK3 | RIO kinase 3 | -0.026722 |
| NOP58 | NOP58 ribonucleoprotein | -0.0264127 |
| COL1A2 | collagen, type I, alpha 2 | -0.0263551 |
| TXNIP | thioredoxin interacting protein | -0.0263549 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0263537 |
| TRIM2 | tripartite motif containing 2 | -0.0263066 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.026277 |
| OGA | O-GlcNAcase | -0.0260044 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.025679 |
| TAC4 | tachykinin 4 (hemokinin) | -0.0256371 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0252766 |
| TMEM87A | transmembrane protein 87A | -0.0251958 |
