| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.103623 |
| EFNA5 | ephrin-A5 | 0.0985884 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0928668 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0849158 |
| CP | ceruloplasmin (ferroxidase) | 0.0800402 |
| NRG3 | neuregulin 3 | 0.0718333 |
| HLA-B | major histocompatibility complex, class I, B | 0.0684336 |
| CFB | complement factor B | 0.062031 |
| RAD51B | RAD51 paralog B | 0.0595644 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.058687 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0573848 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0571005 |
| APOL1 | apolipoprotein L, 1 | 0.0568298 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0537283 |
| RNF213 | ring finger protein 213 | 0.053618 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0515249 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0493701 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0491293 |
| TGM2 | transglutaminase 2 | 0.0491189 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0411883 |
| TMC5 | transmembrane channel-like 5 | 0.0403203 |
| MT2A | metallothionein 2A | 0.0396881 |
| CMIP | c-Maf inducing protein | 0.0394063 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0385883 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0377249 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0376999 |
| LCN2 | lipocalin 2 | 0.0374533 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0372433 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0371909 |
| SEPTIN9 | septin 9 | 0.0359211 |
| HLA-C | major histocompatibility complex, class I, C | 0.03573 |
| KIAA1217 | KIAA1217 | 0.0343863 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0335451 |
| ATXN1 | ataxin 1 | 0.0326607 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0319407 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0318935 |
| KYNU | kynureninase | 0.0317868 |
| MUC4 | mucin 4, cell surface associated | 0.0315082 |
| PLEC | plectin | 0.0314663 |
| MX2 | MX dynamin-like GTPase 2 | 0.0312912 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.031172 |
| NABP1 | nucleic acid binding protein 1 | 0.0308706 |
| APOL2 | apolipoprotein L, 2 | 0.030753 |
| MT1E | metallothionein 1E | 0.0302577 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0302131 |
| SGMS2 | sphingomyelin synthase 2 | 0.0297072 |
| MUC16 | mucin 16, cell surface associated | 0.0295074 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0290531 |
| EGR1 | early growth response 1 | 0.0284164 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0283462 |
| MX1 | MX dynamin-like GTPase 1 | 0.0273356 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0266691 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0262711 |
| INTS6 | integrator complex subunit 6 | 0.0261847 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0261555 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0261129 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.025021 |
| PMP22 | peripheral myelin protein 22 | 0.0246064 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0245204 |
| FAM107B | family with sequence similarity 107, member B | 0.0241434 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.024013 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0234 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0233535 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0230633 |
| KRT19 | keratin 19, type I | 0.0230022 |
| HLA-E | major histocompatibility complex, class I, E | 0.0228512 |
| MYO1E | myosin IE | 0.0227111 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0225081 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | 0.0224803 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0224125 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0222266 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0221666 |
| RIGI | RNA sensor RIG-I | 0.0221464 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0220307 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0219875 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0217438 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0215492 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.02152 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0214781 |
| SP100 | SP100 nuclear antigen | 0.021377 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0211648 |
| RPS8 | ribosomal protein S8 | 0.0210285 |
| RPS12 | ribosomal protein S12 | 0.0205497 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0204895 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0204459 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0204454 |
| KLF6 | Kruppel-like factor 6 | 0.0202717 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0202468 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0200826 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.019918 |
| RPS3 | ribosomal protein S3 | 0.0198693 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0196629 |
| PCDH7 | protocadherin 7 | 0.0195352 |
| IFI44L | interferon-induced protein 44-like | 0.0194322 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0192028 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0190663 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0189073 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0187964 |
| RPL13A | ribosomal protein L13a | 0.0186194 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0185851 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.232856 |
| TMSB10 | thymosin beta 10 | -0.176863 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.166661 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.11787 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0955603 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0944042 |
| NDRG1 | N-myc downstream regulated 1 | -0.0901172 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0891215 |
| POTEF | POTE ankyrin domain family, member F | -0.0875167 |
| TMSB4X | thymosin beta 4, X-linked | -0.0821971 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0810463 |
| S100A6 | S100 calcium binding protein A6 | -0.0805077 |
| ACTG1 | actin gamma 1 | -0.0803192 |
| FTL | ferritin, light polypeptide | -0.080194 |
| PKM | pyruvate kinase, muscle | -0.0784097 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0781433 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0725729 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.070665 |
| SPAG9 | sperm associated antigen 9 | -0.0687722 |
| RBM39 | RNA binding motif protein 39 | -0.0659609 |
| VIM | vimentin | -0.0646297 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0641973 |
| LAMB3 | laminin, beta 3 | -0.0627647 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0598626 |
| PGK1 | phosphoglycerate kinase 1 | -0.0592065 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0589278 |
| RIOK3 | RIO kinase 3 | -0.0580007 |
| MMP7 | matrix metallopeptidase 7 | -0.0577701 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0566544 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0558741 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0554634 |
| FLNB | filamin B, beta | -0.0543481 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.054281 |
| EZR | ezrin | -0.0540715 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0536323 |
| RTN4 | reticulon 4 | -0.0533046 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0522512 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0514842 |
| MAP1B | microtubule-associated protein 1B | -0.0507894 |
| UBC | ubiquitin C | -0.0494534 |
| RPLP1 | ribosomal protein, large, P1 | -0.0493512 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.048755 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0486108 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0474531 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0470261 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.045651 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0453638 |
| TPM4 | tropomyosin 4 | -0.0452452 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0446727 |
| CCNL1 | cyclin L1 | -0.0433801 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0428033 |
| ASPH | aspartate beta-hydroxylase | -0.0418216 |
| HELZ | helicase with zinc finger | -0.0411785 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0409731 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0407885 |
| JUP | junction plakoglobin | -0.0406888 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0404588 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0403398 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.040037 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0400315 |
| OGA | O-GlcNAcase | -0.0399732 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0397516 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0387978 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0384563 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0381171 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0380141 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0378352 |
| PLAU | plasminogen activator, urokinase | -0.0376402 |
| TXNIP | thioredoxin interacting protein | -0.037486 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0363587 |
| MT1X | metallothionein 1X | -0.0361834 |
| GNAS | GNAS complex locus | -0.0361562 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0360873 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0358395 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0357979 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0357755 |
| GOLGA4 | golgin A4 | -0.035417 |
| MEF2A | myocyte enhancer factor 2A | -0.0352353 |
| FAM13A | family with sequence similarity 13, member A | -0.0351474 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0349835 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.034981 |
| CANX | calnexin | -0.0346288 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0342814 |
| IER3 | immediate early response 3 | -0.0341918 |
| SEC24A | SEC24 family member A | -0.0341803 |
| TFG | TRK-fused gene | -0.0338861 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0336283 |
| JMJD1C | jumonji domain containing 1C | -0.0333862 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0332267 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0329827 |
| TOP1 | topoisomerase (DNA) I | -0.0329354 |
| FAM162A | family with sequence similarity 162, member A | -0.0329065 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0328305 |
| SRP54 | signal recognition particle 54kDa | -0.0328033 |
| LMO7 | LIM domain 7 | -0.0326709 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.031994 |
| NUP58 | nucleoporin 58 | -0.0319582 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0314754 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0311397 |
| COPA | coatomer protein complex, subunit alpha | -0.0311189 |
