| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.199527 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.135364 |
| LCN2 | lipocalin 2 | 0.118428 |
| SMAD3 | SMAD family member 3 | 0.110105 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.105015 |
| MYO1E | myosin IE | 0.0894847 |
| EXT1 | exostosin glycosyltransferase 1 | 0.086672 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0756963 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0713971 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0713651 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0688222 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0676371 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0662809 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0655974 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0645284 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0621403 |
| B2M | beta-2-microglobulin | 0.057627 |
| TJP1 | tight junction protein 1 | 0.054737 |
| TMC5 | transmembrane channel-like 5 | 0.0515681 |
| HLA-B | major histocompatibility complex, class I, B | 0.0473621 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0455184 |
| PHF3 | PHD finger protein 3 | 0.0446347 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0442756 |
| ANXA2 | annexin A2 | 0.0441071 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0437987 |
| EFNB2 | ephrin-B2 | 0.0426483 |
| SIK3 | SIK family kinase 3 | 0.042149 |
| ZNF292 | zinc finger protein 292 | 0.0415085 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0414957 |
| MYO5B | myosin VB | 0.0404402 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0396481 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0396362 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0395785 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0391231 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0388064 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0380123 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0364306 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0352837 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0351653 |
| SEPTIN9 | septin 9 | 0.0347538 |
| RPL23 | ribosomal protein L23 | 0.0339644 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0334977 |
| ADAR | adenosine deaminase, RNA-specific | 0.0332851 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0328974 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0328583 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0327594 |
| MCU | mitochondrial calcium uniporter | 0.0326735 |
| BCL2L1 | BCL2-like 1 | 0.0324514 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0312674 |
| KYNU | kynureninase | 0.0311207 |
| MCL1 | myeloid cell leukemia 1 | 0.0306911 |
| YAP1 | Yes-associated protein 1 | 0.0305995 |
| ATF6 | activating transcription factor 6 | 0.0302908 |
| RND3 | Rho family GTPase 3 | 0.0300855 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0299454 |
| FTL | ferritin, light polypeptide | 0.0299319 |
| FAT1 | FAT atypical cadherin 1 | 0.0298297 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0295076 |
| MAP7 | microtubule-associated protein 7 | 0.0293923 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0290773 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0288271 |
| UBC | ubiquitin C | 0.0286911 |
| FHL2 | four and a half LIM domains 2 | 0.0285559 |
| TRIM2 | tripartite motif containing 2 | 0.0284428 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0282834 |
| TMEM65 | transmembrane protein 65 | 0.0272226 |
| PDZD8 | PDZ domain containing 8 | 0.0270175 |
| STK24 | serine/threonine kinase 24 | 0.0269962 |
| RPS8 | ribosomal protein S8 | 0.0268417 |
| POU2F2 | POU class 2 homeobox 2 | 0.0267256 |
| HKDC1 | hexokinase domain containing 1 | 0.0266865 |
| RPL35A | ribosomal protein L35a | 0.0265031 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0263694 |
| RPL26 | ribosomal protein L26 | 0.0261682 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0260627 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0260581 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0259819 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0257164 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0256868 |
| ETV6 | ets variant 6 | 0.0251634 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0247219 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.024516 |
| ATXN1 | ataxin 1 | 0.0245147 |
| IFNGR1 | interferon gamma receptor 1 | 0.0242848 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0240134 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0239886 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0235427 |
| CTSB | cathepsin B | 0.0232297 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0232276 |
| EZR | ezrin | 0.0230065 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0229582 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0225929 |
| LDHA | lactate dehydrogenase A | 0.0225317 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0224669 |
| CDHR2 | cadherin-related family member 2 | 0.0224037 |
| DUSP10 | dual specificity phosphatase 10 | 0.0222989 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0221347 |
| POTEF | POTE ankyrin domain family, member F | 0.0215022 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0213993 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0213417 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.120284 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.110628 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0999764 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0937227 |
| RIGI | RNA sensor RIG-I | -0.0900188 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0859169 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0746401 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0711211 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0695858 |
| SP100 | SP100 nuclear antigen | -0.0642247 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0577466 |
| XAF1 | XIAP associated factor 1 | -0.0563187 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0539189 |
| H1-0 | H1.0 linker histone | -0.0505076 |
| PRKCA | protein kinase C, alpha | -0.0492409 |
| MX1 | MX dynamin-like GTPase 1 | -0.0472802 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0451451 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.045047 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0447266 |
| PTMA | prothymosin, alpha | -0.0446834 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0446593 |
| SSH2 | slingshot protein phosphatase 2 | -0.0446269 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0431234 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0405316 |
| NDRG1 | N-myc downstream regulated 1 | -0.0396343 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0392578 |
| ITGA6 | integrin, alpha 6 | -0.0392081 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0383869 |
| LYZ | lysozyme | -0.0370932 |
| DIAPH3 | diaphanous-related formin 3 | -0.0370417 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0368054 |
| TXNIP | thioredoxin interacting protein | -0.0356837 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0351819 |
| MECOM | MDS1 and EVI1 complex locus | -0.0349594 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0343458 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0341226 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0339544 |
| CCNL1 | cyclin L1 | -0.0338447 |
| JUN | jun proto-oncogene | -0.0337376 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0329627 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0316925 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0312306 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0305544 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0300676 |
| PLSCR1 | phospholipid scramblase 1 | -0.0298271 |
| B3GALT5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | -0.0293738 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0292804 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0292507 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0290483 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.028774 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0286339 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0283975 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0281552 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.027993 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0272682 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.026987 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0268937 |
| RAD51B | RAD51 paralog B | -0.0264751 |
| STK39 | serine threonine kinase 39 | -0.0256555 |
| PRELID2 | PRELI domain containing 2 | -0.0255719 |
| PMP22 | peripheral myelin protein 22 | -0.0255544 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0254807 |
| APOL1 | apolipoprotein L, 1 | -0.0253576 |
| RNF213 | ring finger protein 213 | -0.0249383 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.024935 |
| AHNAK | AHNAK nucleoprotein | -0.0248393 |
| RBM39 | RNA binding motif protein 39 | -0.0245875 |
| POF1B | premature ovarian failure, 1B | -0.0245031 |
| PTGR1 | prostaglandin reductase 1 | -0.024419 |
| DGKH | diacylglycerol kinase, eta | -0.0243923 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0243733 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0243029 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0234938 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0228502 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0226722 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0225933 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0220777 |
| TNS4 | tensin 4 | -0.021604 |
| PLIN2 | perilipin 2 | -0.0215546 |
| PTEN | phosphatase and tensin homolog | -0.0214615 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0213811 |
| KIF16B | kinesin family member 16B | -0.0213266 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0211909 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0205825 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0204873 |
| PLSCR2 | phospholipid scramblase 2 | -0.019859 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0198099 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0197206 |
| FOXP1 | forkhead box P1 | -0.019655 |
| ABLIM1 | actin binding LIM protein 1 | -0.0195491 |
| CCDC146 | coiled-coil domain containing 146 | -0.0195303 |
| OXSR1 | oxidative stress responsive 1 | -0.019379 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0192565 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0192205 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.018991 |
| ITGA1 | integrin, alpha 1 | -0.0188583 |
| CD46 | CD46 molecule, complement regulatory protein | -0.018756 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0187486 |
| STYXL2 | serine/threonine/tyrosine interacting like 2 | -0.0187383 |
| MKI67 | marker of proliferation Ki-67 | -0.0185635 |
