Lapatinib ditosylate_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.143974
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.106417
FAM13A family with sequence similarity 13, member A 0.105268
IGFBP3 insulin-like growth factor binding protein 3 0.0962896
TGFBI transforming growth factor, beta-induced, 68kDa 0.095024
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0849677
NDRG1 N-myc downstream regulated 1 0.0803145
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0801223
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0760917
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0663591
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0658206
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0637667
NAV2 neuron navigator 2 0.0637647
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0614208
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0569163
FAM219A family with sequence similarity 219, member A 0.0559113
BACE2 beta-site APP-cleaving enzyme 2 0.0558175
MKI67 marker of proliferation Ki-67 0.054598
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0541039
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0507828
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0496091
CENPF centromere protein F, 350/400kDa 0.0476589
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0467611
SQSTM1 sequestosome 1 0.0436574
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0433384
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0413426
SMAD3 SMAD family member 3 0.0407148
CDK19 cyclin-dependent kinase 19 0.0401616
FNIP1 folliculin interacting protein 1 0.0390857
ANLN anillin, actin binding protein 0.038804
HLA-B major histocompatibility complex, class I, B 0.0383594
FTH1 ferritin, heavy polypeptide 1 0.038298
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0369282
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0368328
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0367526
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0361479
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0361456
B2M beta-2-microglobulin 0.0352147
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0351164
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0347988
RAB7A RAB7A, member RAS oncogene family 0.0340628
RUNX1 runt-related transcription factor 1 0.0338029
KYNU kynureninase 0.0336292
TENT5A terminal nucleotidyltransferase 5A 0.0334335
EGR1 early growth response 1 0.0331691
FOSL1 FOS-like antigen 1 0.0329875
VEGFA vascular endothelial growth factor A 0.0316511
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0315381
GANAB glucosidase, alpha; neutral AB 0.0305742
HELZ helicase with zinc finger 0.0304299
CTSB cathepsin B 0.0304014
YEATS2 YEATS domain containing 2 0.0301547
NLGN1 neuroligin 1 0.0300986
DDIT4 DNA-damage-inducible transcript 4 0.0298069
ARRDC3 arrestin domain containing 3 0.0297611
COL5A1 collagen, type V, alpha 1 0.0294878
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0288541
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0282734
PMM2 phosphomannomutase 2 0.028074
NIPBL Nipped-B homolog (Drosophila) 0.0279372
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0276599
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.027539
ESYT2 extended synaptotagmin-like protein 2 0.0275349
GLCCI1 glucocorticoid induced 1 0.0272012
C1S complement component 1, s subcomponent 0.0271989
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0270992
PEG10 paternally expressed 10 0.0266231
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.026595
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0264198
JARID2 jumonji, AT rich interactive domain 2 0.026023
PCBP2 poly(rC) binding protein 2 0.0259005
ARHGAP32 Rho GTPase activating protein 32 0.0258977
SMC4 structural maintenance of chromosomes 4 0.0253328
MCL1 myeloid cell leukemia 1 0.0250315
CD109 CD109 molecule 0.0249813
ADM adrenomedullin 0.0246594
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0244667
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0240536
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0239315
SUCO SUN domain containing ossification factor 0.0238781
AKAP12 A kinase (PRKA) anchor protein 12 0.0236857
CEMIP cell migration inducing protein, hyaluronan binding 0.0236048
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0235834
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0232265
TXNRD1 thioredoxin reductase 1 0.0230377
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0229917
NBAS neuroblastoma amplified sequence 0.0228997
DPYSL2 dihydropyrimidinase-like 2 0.0219198
KIAA1217 KIAA1217 0.021878
PHC3 polyhomeotic homolog 3 (Drosophila) 0.02167
SFXN1 sideroflexin 1 0.0215749
POM121C POM121 transmembrane nucleoporin C 0.0212997
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0212756
AHCYL1 adenosylhomocysteinase-like 1 0.0212602
FUBP1 far upstream element (FUSE) binding protein 1 0.0211636
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0207787
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0207555
AKAP9 A kinase (PRKA) anchor protein 9 0.0205628
CORO1C coronin, actin binding protein, 1C 0.0203777
NUP58 nucleoporin 58 0.0203669

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.264252
NALF1 NALCN channel auxiliary factor 1 -0.151837
AHNAK AHNAK nucleoprotein -0.141234
FN1 fibronectin 1 -0.100609
GARS1 glycyl-tRNA synthetase 1 -0.0821551
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0803682
CANX calnexin -0.0741784
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0736722
DST dystonin -0.0734386
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0705787
VIM vimentin -0.0668496
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0654578
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0622489
PTMA prothymosin, alpha -0.0599055
TPM4 tropomyosin 4 -0.059207
ASPH aspartate beta-hydroxylase -0.0590706
PDE4D phosphodiesterase 4D, cAMP-specific -0.0580636
LMAN1 lectin, mannose-binding, 1 -0.0577664
FTL ferritin, light polypeptide -0.0556332
PDLIM5 PDZ and LIM domain 5 -0.0531002
VCL vinculin -0.052551
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0516975
CALD1 caldesmon 1 -0.0457798
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0438497
SDK1 sidekick cell adhesion molecule 1 -0.0438023
PDIA3 protein disulfide isomerase family A, member 3 -0.0436059
RPS24 ribosomal protein S24 -0.0432683
NAV3 neuron navigator 3 -0.0426229
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0419928
TNS3 tensin 3 -0.0414458
PCNX4 pecanex 4 -0.0392831
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.038796
TNNC1 troponin C type 1 (slow) -0.0383689
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0383477
ATXN1 ataxin 1 -0.0375203
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0373035
ZNF804A zinc finger protein 804A -0.0372209
BPTF bromodomain PHD finger transcription factor -0.0371904
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0364712
IGFBP5 insulin-like growth factor binding protein 5 -0.0355465
CAVIN1 caveolae associated protein 1 -0.035214
LRRC49 leucine rich repeat containing 49 -0.0348797
ANTXR2 anthrax toxin receptor 2 -0.0343507
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0340032
INTS6 integrator complex subunit 6 -0.033595
RTN4 reticulon 4 -0.0328661
HMGA2 high mobility group AT-hook 2 -0.0327134
MBD5 methyl-CpG binding domain protein 5 -0.0326969
INHBA inhibin, beta A -0.0326691
RPS27A ribosomal protein S27a -0.0325113
S100A6 S100 calcium binding protein A6 -0.0323685
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0323059
ZMYND8 zinc finger, MYND-type containing 8 -0.032194
PTCHD4 patched domain containing 4 -0.0320693
CDK13 cyclin-dependent kinase 13 -0.0320045
NAV1 neuron navigator 1 -0.031931
SDC4 syndecan 4 -0.0317427
PKM pyruvate kinase, muscle -0.0308107
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0301453
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0298776
PHF3 PHD finger protein 3 -0.0296455
FBXO11 F-box protein 11 -0.0293427
ALCAM activated leukocyte cell adhesion molecule -0.0289404
AK1 adenylate kinase 1 -0.028293
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0280804
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0280665
ANKRD11 ankyrin repeat domain 11 -0.0273593
EGFR epidermal growth factor receptor -0.027279
RRBP1 ribosome binding protein 1 -0.0271015
SBF2 SET binding factor 2 -0.0267547
WASF2 WAS protein family, member 2 -0.026651
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0262668
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0258043
NUMB numb homolog (Drosophila) -0.0257078
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0255988
MB21D2 Mab-21 domain containing 2 -0.0252881
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0252683
USP34 ubiquitin specific peptidase 34 -0.025261
STK17A serine/threonine kinase 17a -0.0252106
TRIO trio Rho guanine nucleotide exchange factor -0.025089
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0250605
MACF1 microtubule-actin crosslinking factor 1 -0.0249765
FNDC3B fibronectin type III domain containing 3B -0.0248628
RTN3 reticulon 3 -0.0248377
SOX5 SRY (sex determining region Y)-box 5 -0.024599
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0244697
FMN1 formin 1 -0.0244294
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0244139
PRR16 proline rich 16 -0.0242486
TNRC18 trinucleotide repeat containing 18 -0.0241752
VCP valosin containing protein -0.0239582
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0238599
WSB1 WD repeat and SOCS box containing 1 -0.0237401
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.023729
LOX lysyl oxidase -0.0235552
ENO1 enolase 1, (alpha) -0.023315
TMEM132B transmembrane protein 132B -0.0232992
SASH1 SAM and SH3 domain containing 1 -0.0230312
CUX1 cut-like homeobox 1 -0.0229624
MAP4 microtubule-associated protein 4 -0.0228932