| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.122288 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0887351 |
| INTS6 | integrator complex subunit 6 | 0.0786202 |
| EGR1 | early growth response 1 | 0.0718061 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0672795 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0629199 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0604814 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0588156 |
| TMSB10 | thymosin beta 10 | 0.0544575 |
| LRRC23 | leucine rich repeat containing 23 | 0.0520616 |
| NDRG1 | N-myc downstream regulated 1 | 0.048757 |
| CTBP2 | C-terminal binding protein 2 | 0.0450389 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.045026 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0424742 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0403852 |
| POTEF | POTE ankyrin domain family, member F | 0.038277 |
| FHIT | fragile histidine triad | 0.0381218 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0372808 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0366216 |
| MT2A | metallothionein 2A | 0.0360982 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0356154 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0351306 |
| PCBP2 | poly(rC) binding protein 2 | 0.0347309 |
| BAIAP2 | BAI1-associated protein 2 | 0.0345678 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0344081 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0339646 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0336444 |
| MCL1 | myeloid cell leukemia 1 | 0.0333023 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0328574 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0323074 |
| ENO1 | enolase 1, (alpha) | 0.0315475 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0311245 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0303967 |
| MACROD2 | MACRO domain containing 2 | 0.0291403 |
| SECISBP2 | SECIS binding protein 2 | 0.0279414 |
| PTMA | prothymosin, alpha | 0.0274317 |
| RUNX1 | runt-related transcription factor 1 | 0.0270323 |
| ABHD5 | abhydrolase domain containing 5 | 0.0270129 |
| TGFB1 | transforming growth factor, beta 1 | 0.0268573 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0266569 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0258635 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0256143 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0255641 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0255571 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0255035 |
| EFNB2 | ephrin-B2 | 0.025295 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0252168 |
| JUN | jun proto-oncogene | 0.0251703 |
| RCC1 | regulator of chromosome condensation 1 | 0.0248113 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0244632 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0244323 |
| TPI1 | triosephosphate isomerase 1 | 0.0241711 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0238042 |
| RPL23 | ribosomal protein L23 | 0.0235277 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0233956 |
| TXNIP | thioredoxin interacting protein | 0.0232876 |
| ASS1 | argininosuccinate synthase 1 | 0.0232311 |
| GPC5 | glypican 5 | 0.0231321 |
| TLN1 | talin 1 | 0.0226894 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0226763 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0220595 |
| HOMER1 | homer scaffolding protein 1 | 0.0220079 |
| CCNYL1 | cyclin Y-like 1 | 0.0214664 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0211526 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0211212 |
| KLHL29 | kelch-like family member 29 | 0.0211127 |
| NABP1 | nucleic acid binding protein 1 | 0.0210823 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.02082 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0207717 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0205903 |
| FBXO32 | F-box protein 32 | 0.0204964 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0203937 |
| TRIM72 | tripartite motif containing 72, E3 ubiquitin protein ligase | 0.0200598 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0198952 |
| STPG4 | sperm-tail PG-rich repeat containing 4 | 0.0198796 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.0197836 |
| ATF3 | activating transcription factor 3 | 0.0196721 |
| SGMS2 | sphingomyelin synthase 2 | 0.019626 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0194708 |
| LMNA | lamin A/C | 0.0192328 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0191698 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0191313 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0191293 |
| CMIP | c-Maf inducing protein | 0.0190929 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0189585 |
| ARRDC3 | arrestin domain containing 3 | 0.0188766 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0188309 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0187878 |
| SEPTIN9 | septin 9 | 0.0185621 |
| RPL21 | ribosomal protein L21 | 0.0185432 |
| ACTG1 | actin gamma 1 | 0.0185424 |
| HDAC4 | histone deacetylase 4 | 0.0185386 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0184227 |
| PRKCA | protein kinase C, alpha | 0.0181399 |
| CLU | clusterin | 0.0179924 |
| FAM107B | family with sequence similarity 107, member B | 0.0179548 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0179177 |
| KITLG | KIT ligand | 0.0179035 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0178836 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0178661 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.130789 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.115021 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0926501 |
| AHNAK | AHNAK nucleoprotein | -0.0720157 |
| TXNRD1 | thioredoxin reductase 1 | -0.0718611 |
| FTL | ferritin, light polypeptide | -0.0666836 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0636811 |
| TPM4 | tropomyosin 4 | -0.0612098 |
| GOLGA4 | golgin A4 | -0.06093 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0582635 |
| RRBP1 | ribosome binding protein 1 | -0.0578849 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0560344 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0558311 |
| SETD5 | SET domain containing 5 | -0.0554424 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0553484 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0552826 |
| RBM39 | RNA binding motif protein 39 | -0.0550403 |
| RBM25 | RNA binding motif protein 25 | -0.0542705 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0539139 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0522086 |
| MED13L | mediator complex subunit 13-like | -0.0514273 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0473007 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0466886 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0461563 |
| JMJD1C | jumonji domain containing 1C | -0.0460167 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0459728 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0458576 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0456071 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0451135 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0444254 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0443644 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0440496 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0436283 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0432691 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0432057 |
| MATR3 | matrin 3 | -0.04293 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0429219 |
| FDPS | farnesyl diphosphate synthase | -0.0424438 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0424058 |
| PGK1 | phosphoglycerate kinase 1 | -0.0418657 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0417836 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0417535 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0417137 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0416397 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0415725 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0405843 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0403323 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0401768 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0401757 |
| OGA | O-GlcNAcase | -0.040099 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0397605 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0393315 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0391502 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0385404 |
| GOLGB1 | golgin B1 | -0.0384612 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0381164 |
| VMP1 | vacuole membrane protein 1 | -0.0376471 |
| TMEM41B | transmembrane protein 41B | -0.037127 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0364773 |
| CANX | calnexin | -0.035975 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0359444 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0358561 |
| NF1 | neurofibromin 1 | -0.035613 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0355401 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0352602 |
| RPS6 | ribosomal protein S6 | -0.0351995 |
| ZNF292 | zinc finger protein 292 | -0.0351346 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0348356 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0347655 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0342042 |
| KPNB1 | karyopherin (importin) beta 1 | -0.034062 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0339787 |
| CD2AP | CD2-associated protein | -0.0339694 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0339574 |
| RARS1 | arginyl-tRNA synthetase 1 | -0.0337622 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0337317 |
| SRP54 | signal recognition particle 54kDa | -0.03367 |
| YME1L1 | YME1-like 1 ATPase | -0.0334016 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0330424 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0327741 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0321742 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.032043 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0320175 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0318382 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0318259 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0316893 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0316272 |
| ARF4 | ADP-ribosylation factor 4 | -0.0316059 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0313948 |
| COPA | coatomer protein complex, subunit alpha | -0.0312045 |
| INSIG2 | insulin induced gene 2 | -0.031028 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0307689 |
| RPL4 | ribosomal protein L4 | -0.0307037 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0306695 |
| RLF | rearranged L-myc fusion | -0.0304916 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0303871 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0303578 |
| USP34 | ubiquitin specific peptidase 34 | -0.0302691 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0301084 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0300091 |
