| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.184566 |
| SMAD3 | SMAD family member 3 | 0.140145 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0957491 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0922553 |
| APP | amyloid beta (A4) precursor protein | 0.091048 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0820352 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.078745 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0770724 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0756257 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0715795 |
| GOLGA4 | golgin A4 | 0.0674812 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0653184 |
| WWC1 | WW and C2 domain containing 1 | 0.0651134 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0627952 |
| ECT2 | epithelial cell transforming 2 | 0.0627079 |
| SQSTM1 | sequestosome 1 | 0.0609145 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0602627 |
| TXNRD1 | thioredoxin reductase 1 | 0.0602624 |
| ZNF292 | zinc finger protein 292 | 0.0590313 |
| RPL26 | ribosomal protein L26 | 0.0587117 |
| HELZ | helicase with zinc finger | 0.0586761 |
| GOLGB1 | golgin B1 | 0.057822 |
| RPL13A | ribosomal protein L13a | 0.0568426 |
| RPS8 | ribosomal protein S8 | 0.0551229 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0551087 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0548595 |
| FLNB | filamin B, beta | 0.054528 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0537356 |
| ANXA2 | annexin A2 | 0.0534946 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0523123 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0518374 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0514332 |
| RPL23 | ribosomal protein L23 | 0.0514069 |
| RPS12 | ribosomal protein S12 | 0.0512009 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0511584 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0503606 |
| RPS3 | ribosomal protein S3 | 0.0501789 |
| SNX9 | sorting nexin 9 | 0.050096 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0493519 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0489259 |
| LAMB3 | laminin, beta 3 | 0.0466909 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0466011 |
| RUNX1 | runt-related transcription factor 1 | 0.0454769 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0438629 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0435818 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0435241 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0435224 |
| RYBP | RING1 and YY1 binding protein | 0.0433311 |
| RPL35A | ribosomal protein L35a | 0.0429765 |
| SPAG9 | sperm associated antigen 9 | 0.0427355 |
| ANXA1 | annexin A1 | 0.0425215 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0420317 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0417438 |
| SIK3 | SIK family kinase 3 | 0.0416749 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0413479 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0399521 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0399262 |
| EMP1 | epithelial membrane protein 1 | 0.0398034 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0393872 |
| CTBP2 | C-terminal binding protein 2 | 0.038998 |
| CALR | calreticulin | 0.0388995 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0385352 |
| FLNA | filamin A, alpha | 0.038521 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0380785 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0380566 |
| RACK1 | receptor for activated C kinase 1 | 0.0378631 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0374503 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0372624 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0370286 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0369413 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.0368272 |
| AFDN | afadin, adherens junction formation factor | 0.0364133 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0362615 |
| RPL5 | ribosomal protein L5 | 0.0361332 |
| JMJD1C | jumonji domain containing 1C | 0.0359076 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0356162 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0355261 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0354908 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0353211 |
| ACTN4 | actinin, alpha 4 | 0.0351612 |
| PTK2 | protein tyrosine kinase 2 | 0.0341466 |
| IRF1 | interferon regulatory factor 1 | 0.0340798 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0339683 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0339471 |
| NCKAP1 | NCK-associated protein 1 | 0.0338069 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0336865 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0336816 |
| TPD52 | tumor protein D52 | 0.0335224 |
| ORC4 | origin recognition complex, subunit 4 | 0.0334463 |
| RPS2 | ribosomal protein S2 | 0.0334342 |
| MLF1 | myeloid leukemia factor 1 | 0.0334334 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0331892 |
| SGMS2 | sphingomyelin synthase 2 | 0.0329771 |
| SLMAP | sarcolemma associated protein | 0.0326041 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0323474 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0322737 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0321115 |
| TUSC3 | tumor suppressor candidate 3 | 0.0319696 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0319561 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0317791 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.101124 |
| TMSB10 | thymosin beta 10 | -0.0724981 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0683099 |
| HMGA2 | high mobility group AT-hook 2 | -0.0638373 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.052329 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0468424 |
| RAD51B | RAD51 paralog B | -0.0467436 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.046393 |
| FHIT | fragile histidine triad | -0.0458077 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0454496 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0449398 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0444078 |
| TPM4 | tropomyosin 4 | -0.0427743 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0421462 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.041362 |
| ATG7 | autophagy related 7 | -0.0397657 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0392895 |
| PTMA | prothymosin, alpha | -0.0380938 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0377521 |
| FTL | ferritin, light polypeptide | -0.0376676 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0375289 |
| PCED1B | PC-esterase domain containing 1B | -0.0368054 |
| ASPH | aspartate beta-hydroxylase | -0.035885 |
| DIAPH3 | diaphanous-related formin 3 | -0.0346469 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0345412 |
| AHNAK | AHNAK nucleoprotein | -0.0328491 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0306011 |
| OXR1 | oxidation resistance 1 | -0.0293949 |
| VCL | vinculin | -0.0287917 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.028695 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | -0.028577 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0284515 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0272422 |
| VCAN | versican | -0.0267991 |
| PRELID2 | PRELI domain containing 2 | -0.0263445 |
| PKM | pyruvate kinase, muscle | -0.0261525 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0254183 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0252195 |
| CBX3 | chromobox homolog 3 | -0.0248438 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0247653 |
| GLIS3 | GLIS family zinc finger 3 | -0.0245015 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0243358 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0239495 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0237865 |
| NDUFAF2 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 | -0.0235571 |
| CD44 | CD44 molecule (Indian blood group) | -0.0228409 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0228324 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0226734 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0223876 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0217142 |
| RBM25 | RNA binding motif protein 25 | -0.0216882 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0214364 |
| S100A6 | S100 calcium binding protein A6 | -0.0209135 |
| AIG1 | androgen-induced 1 | -0.0207824 |
| UGT2B7 | UDP glucuronosyltransferase 2 family, polypeptide B7 | -0.0206966 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0206176 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0205943 |
| HELLS | helicase, lymphoid-specific | -0.0204183 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0203986 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0200841 |
| ITGA6 | integrin, alpha 6 | -0.0195737 |
| TUBA1B | tubulin, alpha 1b | -0.0194067 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0193263 |
| MTAP | methylthioadenosine phosphorylase | -0.0192546 |
| BPTF | bromodomain PHD finger transcription factor | -0.0189228 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0188806 |
| CCND1 | cyclin D1 | -0.0188698 |
| GPR39 | G protein-coupled receptor 39 | -0.0186283 |
| H1-0 | H1.0 linker histone | -0.0185968 |
| SVIL | supervillin | -0.0184654 |
| THOC2 | THO complex 2 | -0.0181687 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0181358 |
| SUMF1 | sulfatase modifying factor 1 | -0.0181283 |
| ABLIM1 | actin binding LIM protein 1 | -0.0176308 |
| EHBP1 | EH domain binding protein 1 | -0.0171075 |
| HMGB1 | high mobility group box 1 | -0.017092 |
| CALD1 | caldesmon 1 | -0.0170004 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | -0.0164836 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0163704 |
| HDAC9 | histone deacetylase 9 | -0.0161135 |
| SEPTIN10 | septin 10 | -0.0159553 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | -0.0159537 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0159021 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0158806 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0158314 |
| DEK | DEK proto-oncogene | -0.0152033 |
| CBX5 | chromobox homolog 5 | -0.0151246 |
| BRCA1 | breast cancer 1, early onset | -0.0150892 |
| RPLP1 | ribosomal protein, large, P1 | -0.0149915 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0149326 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0148194 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0147385 |
| PRSS23 | protease, serine, 23 | -0.0145229 |
| TASOR | transcription activation suppressor | -0.0141946 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0140716 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0139887 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0139085 |
| WASF2 | WAS protein family, member 2 | -0.0137771 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0137471 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0137223 |
