| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.160134 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0992444 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0888667 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0824167 |
| CD44 | CD44 molecule (Indian blood group) | 0.0729605 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0631062 |
| NDRG1 | N-myc downstream regulated 1 | 0.0580244 |
| FAM13A | family with sequence similarity 13, member A | 0.0540108 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0527588 |
| MT2A | metallothionein 2A | 0.0525641 |
| SEPTIN9 | septin 9 | 0.0466774 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0442799 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0440106 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0437374 |
| NAV2 | neuron navigator 2 | 0.0413647 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0399774 |
| RUNX1 | runt-related transcription factor 1 | 0.0395201 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0386273 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.038384 |
| PDE10A | phosphodiesterase 10A | 0.0359313 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0336576 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0322415 |
| SMAD3 | SMAD family member 3 | 0.0318672 |
| VEGFA | vascular endothelial growth factor A | 0.0297117 |
| TNS1 | tensin 1 | 0.0296539 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0285053 |
| CDCP1 | CUB domain containing protein 1 | 0.0277237 |
| DTNA | dystrobrevin, alpha | 0.0273837 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.026861 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0260785 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0260647 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0260132 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.025445 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0250658 |
| ARRDC3 | arrestin domain containing 3 | 0.0243041 |
| HPCAL1 | hippocalcin-like 1 | 0.0237454 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0232097 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.023075 |
| GPC5 | glypican 5 | 0.022988 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0228358 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0221229 |
| LOXL2 | lysyl oxidase-like 2 | 0.0219044 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0217007 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0214971 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0213301 |
| FAM219A | family with sequence similarity 219, member A | 0.0212089 |
| FNIP1 | folliculin interacting protein 1 | 0.0206318 |
| MT1E | metallothionein 1E | 0.0205547 |
| LOX | lysyl oxidase | 0.0205293 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0202227 |
| EMP1 | epithelial membrane protein 1 | 0.0196114 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0189095 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0182887 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0182558 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0180563 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.018052 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.017999 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0179493 |
| FAM107B | family with sequence similarity 107, member B | 0.0178129 |
| MLPH | melanophilin | 0.0177704 |
| MCL1 | myeloid cell leukemia 1 | 0.0175992 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0175773 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0174377 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.017412 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0171038 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0170724 |
| NGLY1 | N-glycanase 1 | 0.0169512 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0166368 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.01662 |
| PCBP3 | poly(rC) binding protein 3 | 0.016612 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0164576 |
| RND3 | Rho family GTPase 3 | 0.0164185 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0163243 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0158158 |
| FLNB | filamin B, beta | 0.0154417 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0153202 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0153004 |
| ARFGEF3 | ARFGEF family member 3 | 0.0152213 |
| RPS12 | ribosomal protein S12 | 0.0148202 |
| RPS8 | ribosomal protein S8 | 0.0147977 |
| YEATS2 | YEATS domain containing 2 | 0.0147832 |
| RPL23 | ribosomal protein L23 | 0.0147535 |
| VEGFC | vascular endothelial growth factor C | 0.0146187 |
| G0S2 | G0/G1 switch 2 | 0.0145512 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0145251 |
| RPL12 | ribosomal protein L12 | 0.0144679 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0143841 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0141185 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0140857 |
| EFNA5 | ephrin-A5 | 0.0140334 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0139092 |
| MT1X | metallothionein 1X | 0.0138572 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0138204 |
| ZNF638 | zinc finger protein 638 | 0.0138201 |
| FAT1 | FAT atypical cadherin 1 | 0.013808 |
| EGR1 | early growth response 1 | 0.0133487 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0133379 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0132468 |
| FOSL1 | FOS-like antigen 1 | 0.0132181 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0130955 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.0835677 |
| VCL | vinculin | -0.069386 |
| PTMA | prothymosin, alpha | -0.0675137 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0638661 |
| CDH13 | cadherin 13 | -0.0624988 |
| TMSB10 | thymosin beta 10 | -0.05589 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0535675 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0506825 |
| ACTG1 | actin gamma 1 | -0.0462948 |
| AHNAK | AHNAK nucleoprotein | -0.0407099 |
| RRBP1 | ribosome binding protein 1 | -0.0404659 |
| PGK1 | phosphoglycerate kinase 1 | -0.0378139 |
| DIAPH2 | diaphanous-related formin 2 | -0.0357881 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.033335 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0320783 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0319098 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0317564 |
| COL1A1 | collagen, type I, alpha 1 | -0.030553 |
| RAD51B | RAD51 paralog B | -0.0303944 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0293914 |
| TENM2 | teneurin transmembrane protein 2 | -0.0268304 |
| FMN1 | formin 1 | -0.0265407 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0264716 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0260711 |
| IGF2 | insulin-like growth factor 2 | -0.0258901 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0257489 |
| FN1 | fibronectin 1 | -0.025613 |
| DST | dystonin | -0.0246292 |
| RRM2 | ribonucleotide reductase M2 | -0.0246156 |
| ASPH | aspartate beta-hydroxylase | -0.0238594 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0235939 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0234456 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0229133 |
| LAMB3 | laminin, beta 3 | -0.0228246 |
| RTN4 | reticulon 4 | -0.0223503 |
| DIAPH3 | diaphanous-related formin 3 | -0.0222745 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0222677 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0220192 |
| TPM1 | tropomyosin 1 (alpha) | -0.0217933 |
| CAVIN1 | caveolae associated protein 1 | -0.0217835 |
| CALD1 | caldesmon 1 | -0.0214976 |
| GNAS | GNAS complex locus | -0.0213683 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0208042 |
| TPM4 | tropomyosin 4 | -0.0203847 |
| IER3 | immediate early response 3 | -0.0201251 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0193181 |
| ANXA2 | annexin A2 | -0.0192992 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0192591 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0192433 |
| TPX2 | TPX2, microtubule-associated | -0.0190171 |
| CCDC91 | coiled-coil domain containing 91 | -0.0187335 |
| MYO10 | myosin X | -0.0187245 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0186828 |
| CANX | calnexin | -0.0185281 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0182157 |
| CLIC4 | chloride intracellular channel 4 | -0.0180332 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0178163 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.017801 |
| SETD5 | SET domain containing 5 | -0.0177673 |
| CENPF | centromere protein F, 350/400kDa | -0.0175654 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0174826 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0174124 |
| SBF2 | SET binding factor 2 | -0.0173688 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0173012 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.017125 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0170615 |
| RAI14 | retinoic acid induced 14 | -0.0167403 |
| EGFR | epidermal growth factor receptor | -0.0165612 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0165077 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0162714 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0162592 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0162589 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0161839 |
| TUBB6 | tubulin, beta 6 class V | -0.01603 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.016005 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0158015 |
| RBM39 | RNA binding motif protein 39 | -0.0157895 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0155726 |
| FBXO11 | F-box protein 11 | -0.0154867 |
| ACTN1 | actinin, alpha 1 | -0.0154856 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0154845 |
| CLMP | CXADR-like membrane protein | -0.0153829 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0153804 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0153677 |
| PRELID2 | PRELI domain containing 2 | -0.0152841 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0149583 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0147829 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0147279 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.014627 |
| CALU | calumenin | -0.0146033 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0144983 |
| NABP1 | nucleic acid binding protein 1 | -0.0144582 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0143493 |
| PLS3 | plastin 3 | -0.0143333 |
| TUBB | tubulin, beta class I | -0.0142415 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.014235 |
| PRSS23 | protease, serine, 23 | -0.0142335 |
| CDK14 | cyclin-dependent kinase 14 | -0.0142083 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0139689 |
| CUX1 | cut-like homeobox 1 | -0.0136715 |
