| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | 0.173849 |
| EXT1 | exostosin glycosyltransferase 1 | 0.099783 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0977608 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0925236 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0713511 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0659907 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0656324 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0646245 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0640282 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0593267 |
| COL5A1 | collagen, type V, alpha 1 | 0.0585284 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0579239 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0577706 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0570616 |
| STC1 | stanniocalcin 1 | 0.0556646 |
| CD44 | CD44 molecule (Indian blood group) | 0.0500271 |
| ASPH | aspartate beta-hydroxylase | 0.0500026 |
| EFNA5 | ephrin-A5 | 0.049539 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.04666 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0462674 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0460024 |
| HLA-B | major histocompatibility complex, class I, B | 0.043674 |
| SQSTM1 | sequestosome 1 | 0.0429844 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0409847 |
| RPS8 | ribosomal protein S8 | 0.0403842 |
| RND3 | Rho family GTPase 3 | 0.040379 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0402195 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0394378 |
| RPL26 | ribosomal protein L26 | 0.0390409 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0390302 |
| EGFR | epidermal growth factor receptor | 0.0387319 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0385504 |
| GLIS3 | GLIS family zinc finger 3 | 0.0380237 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0347768 |
| ATXN1 | ataxin 1 | 0.0346483 |
| GOLGB1 | golgin B1 | 0.034556 |
| PLEC | plectin | 0.0343698 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0335561 |
| NAV2 | neuron navigator 2 | 0.0331284 |
| RPS12 | ribosomal protein S12 | 0.0329674 |
| VEGFA | vascular endothelial growth factor A | 0.0326813 |
| GANAB | glucosidase, alpha; neutral AB | 0.0325758 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0323647 |
| FAM107B | family with sequence similarity 107, member B | 0.0313526 |
| RPL35A | ribosomal protein L35a | 0.0313403 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.030593 |
| RPL13A | ribosomal protein L13a | 0.0304776 |
| RPL37A | ribosomal protein L37a | 0.0297773 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0296888 |
| RPS3 | ribosomal protein S3 | 0.0292791 |
| CFB | complement factor B | 0.0289717 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0279546 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0279083 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0277112 |
| RUNX1 | runt-related transcription factor 1 | 0.0273133 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0272201 |
| COL3A1 | collagen, type III, alpha 1 | 0.0271143 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0270453 |
| RPL23 | ribosomal protein L23 | 0.0269774 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | 0.0267269 |
| NAV1 | neuron navigator 1 | 0.0266473 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0262098 |
| INTS6 | integrator complex subunit 6 | 0.025653 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0253728 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0253107 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0250989 |
| LOXL2 | lysyl oxidase-like 2 | 0.0248427 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0248418 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.024808 |
| FMNL2 | formin-like 2 | 0.0247022 |
| RPS2 | ribosomal protein S2 | 0.0245596 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0242516 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0241755 |
| APP | amyloid beta (A4) precursor protein | 0.0236689 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.023083 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0229437 |
| CDK13 | cyclin-dependent kinase 13 | 0.0226644 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0222836 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0222598 |
| MT2A | metallothionein 2A | 0.0220937 |
| SETBP1 | SET binding protein 1 | 0.0220156 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0217681 |
| MMP3 | matrix metallopeptidase 3 | 0.0216396 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0214452 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0213576 |
| RPL5 | ribosomal protein L5 | 0.0213155 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0212278 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0211811 |
| NEK10 | NIMA-related kinase 10 | 0.0210877 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0208833 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0208511 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0206809 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0206133 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0205044 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.020489 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.020371 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0202893 |
| TLE4 | transducin-like enhancer of split 4 | 0.0202842 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.020127 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0201033 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.274612 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.233693 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.182493 |
| COL1A1 | collagen, type I, alpha 1 | -0.147724 |
| COL1A2 | collagen, type I, alpha 2 | -0.123239 |
| FN1 | fibronectin 1 | -0.117656 |
| PTMA | prothymosin, alpha | -0.117111 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0918348 |
| TMSB10 | thymosin beta 10 | -0.0891644 |
| ATP13A3 | ATPase type 13A3 | -0.0846531 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0833987 |
| TPM4 | tropomyosin 4 | -0.0797267 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0706672 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0687535 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0684612 |
| FTL | ferritin, light polypeptide | -0.0675525 |
| MAP1B | microtubule-associated protein 1B | -0.063473 |
| PKM | pyruvate kinase, muscle | -0.0619002 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0546371 |
| SEPTIN7 | septin 7 | -0.0536348 |
| GOLGA4 | golgin A4 | -0.0527442 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0517166 |
| WASF2 | WAS protein family, member 2 | -0.0516876 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0514437 |
| UBC | ubiquitin C | -0.0508296 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0497199 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0483162 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0472112 |
| SETD5 | SET domain containing 5 | -0.0461058 |
| LOX | lysyl oxidase | -0.0457371 |
| SPAG9 | sperm associated antigen 9 | -0.045212 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0444074 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0434651 |
| CALD1 | caldesmon 1 | -0.043249 |
| TRAM1 | translocation associated membrane protein 1 | -0.0430828 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0421312 |
| USP3 | ubiquitin specific peptidase 3 | -0.0419873 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0418257 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0414612 |
| SBF2 | SET binding factor 2 | -0.0400097 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0388541 |
| VCAN | versican | -0.0381671 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0381496 |
| AXL | AXL receptor tyrosine kinase | -0.0380676 |
| DSTN | destrin (actin depolymerizing factor) | -0.0378775 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0374841 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0370279 |
| TMSB4X | thymosin beta 4, X-linked | -0.0367068 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0364045 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0359882 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0357675 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0356166 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0356027 |
| BBX | bobby sox homolog (Drosophila) | -0.0353565 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.034993 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0347956 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0343634 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0341357 |
| S100A6 | S100 calcium binding protein A6 | -0.033878 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0338761 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0335689 |
| CAVIN1 | caveolae associated protein 1 | -0.0328131 |
| RNF145 | ring finger protein 145 | -0.032658 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0322722 |
| OGA | O-GlcNAcase | -0.0322591 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0321435 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.032137 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0320964 |
| QKI | QKI, KH domain containing, RNA binding | -0.0318373 |
| RBM39 | RNA binding motif protein 39 | -0.0317648 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0309364 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0309363 |
| IER3 | immediate early response 3 | -0.0307925 |
| TPM2 | tropomyosin 2 (beta) | -0.0307085 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0304466 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0303613 |
| RPS6 | ribosomal protein S6 | -0.0301846 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0296724 |
| GNAS | GNAS complex locus | -0.0295357 |
| B2M | beta-2-microglobulin | -0.0295033 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0294888 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0290557 |
| SQLE | squalene epoxidase | -0.0290411 |
| TAGLN2 | transgelin 2 | -0.0290086 |
| HIP1 | huntingtin interacting protein 1 | -0.0285454 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0283911 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0281874 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0278921 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0278823 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0273029 |
| ZNF292 | zinc finger protein 292 | -0.0271199 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0270704 |
| RLF | rearranged L-myc fusion | -0.0268204 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0267741 |
| RIOK3 | RIO kinase 3 | -0.0267383 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0266405 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0266307 |
| COPA | coatomer protein complex, subunit alpha | -0.0266196 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0265991 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0265528 |
