| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | 0.0994914 |
| ATXN1 | ataxin 1 | 0.075472 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0639387 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0561193 |
| INTS6 | integrator complex subunit 6 | 0.0540246 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0534048 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0507457 |
| EXPH5 | exophilin 5 | 0.0502364 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0501582 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0482681 |
| RPS12 | ribosomal protein S12 | 0.0408002 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0399259 |
| RPS3 | ribosomal protein S3 | 0.0388806 |
| TLE4 | transducin-like enhancer of split 4 | 0.0379201 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0363286 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0361382 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0356251 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0336059 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0330203 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0318508 |
| FBXO32 | F-box protein 32 | 0.0306898 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0305548 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0296169 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0293266 |
| SHROOM3 | shroom family member 3 | 0.0289075 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.028725 |
| RASEF | RAS and EF-hand domain containing | 0.0276613 |
| TMC5 | transmembrane channel-like 5 | 0.0274255 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0270441 |
| FRY | furry homolog (Drosophila) | 0.0269106 |
| RPL13A | ribosomal protein L13a | 0.0263097 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0260535 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0251921 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0245546 |
| FAM13A | family with sequence similarity 13, member A | 0.0236209 |
| TUFT1 | tuftelin 1 | 0.0234775 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0234262 |
| RPL26 | ribosomal protein L26 | 0.0229936 |
| SIK3 | SIK family kinase 3 | 0.0228856 |
| EMP1 | epithelial membrane protein 1 | 0.0227822 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0220467 |
| EZR | ezrin | 0.0219905 |
| NEBL | nebulette | 0.0216639 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0207527 |
| LCN2 | lipocalin 2 | 0.0207334 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0201259 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0198704 |
| WLS | wntless Wnt ligand secretion mediator | 0.0194756 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.019473 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | 0.0190022 |
| RND3 | Rho family GTPase 3 | 0.0188982 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0188975 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0183678 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0177982 |
| TNS1 | tensin 1 | 0.0176039 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0173703 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0172839 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.017233 |
| PROM1 | prominin 1 | 0.0172101 |
| EFNB2 | ephrin-B2 | 0.0171735 |
| SMYD3 | SET and MYND domain containing 3 | 0.0171024 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0170872 |
| EPAS1 | endothelial PAS domain protein 1 | 0.016756 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0165301 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.0163754 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0163444 |
| MCU | mitochondrial calcium uniporter | 0.0163191 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0162188 |
| YAP1 | Yes-associated protein 1 | 0.0160539 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0158015 |
| ATF3 | activating transcription factor 3 | 0.015771 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0157001 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0156985 |
| ATOSA | atos homolog A | 0.015679 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | 0.0156699 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0154866 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0154593 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0153912 |
| RFLNA | refilin A | 0.0153212 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0152842 |
| TMEM45B | transmembrane protein 45B | 0.0152342 |
| MPZL3 | myelin protein zero-like 3 | 0.0152182 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0152058 |
| LMO7 | LIM domain 7 | 0.0151571 |
| FHL2 | four and a half LIM domains 2 | 0.0151362 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0151086 |
| SIK2 | salt-inducible kinase 2 | 0.0150231 |
| ARRDC3 | arrestin domain containing 3 | 0.0150074 |
| SGMS2 | sphingomyelin synthase 2 | 0.0149709 |
| FOXO3 | forkhead box O3 | 0.0148883 |
| RPL11 | ribosomal protein L11 | 0.0146864 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0146328 |
| HOXB3 | homeobox B3 | 0.0145144 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.01451 |
| IRS2 | insulin receptor substrate 2 | 0.0144819 |
| HOMER1 | homer scaffolding protein 1 | 0.014134 |
| GIPC2 | GIPC PDZ domain containing family, member 2 | 0.0140837 |
| PCBP2 | poly(rC) binding protein 2 | 0.0140371 |
| SBF2 | SET binding factor 2 | 0.014005 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0139462 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.158241 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.148551 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.109441 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.102574 |
| LAMA4 | laminin, alpha 4 | -0.0912018 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0842665 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0839563 |
| KRT18 | keratin 18, type I | -0.0805586 |
| TMSB10 | thymosin beta 10 | -0.0794778 |
| TXNRD1 | thioredoxin reductase 1 | -0.0776124 |
| RPLP1 | ribosomal protein, large, P1 | -0.0692211 |
| FTL | ferritin, light polypeptide | -0.0687014 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0675415 |
| WASF2 | WAS protein family, member 2 | -0.0667135 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0628408 |
| ANXA2 | annexin A2 | -0.0597192 |
| RPS6 | ribosomal protein S6 | -0.0588556 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0548586 |
| CANX | calnexin | -0.054733 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0538073 |
| LYZ | lysozyme | -0.0536466 |
| AHNAK | AHNAK nucleoprotein | -0.0535809 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.05349 |
| KRT8 | keratin 8, type II | -0.0534624 |
| S100A6 | S100 calcium binding protein A6 | -0.0521955 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0518686 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0517797 |
| PGK1 | phosphoglycerate kinase 1 | -0.0509449 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0500481 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.049731 |
| HDLBP | high density lipoprotein binding protein | -0.0497138 |
| CD2AP | CD2-associated protein | -0.0477513 |
| MKI67 | marker of proliferation Ki-67 | -0.0476612 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0475829 |
| AGR2 | anterior gradient 2 | -0.0472525 |
| LDHA | lactate dehydrogenase A | -0.0465988 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0464292 |
| NF1 | neurofibromin 1 | -0.0439188 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0437142 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0436466 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0435352 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0429997 |
| RRBP1 | ribosome binding protein 1 | -0.0429296 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0425789 |
| PKM | pyruvate kinase, muscle | -0.0425314 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0421108 |
| KRT19 | keratin 19, type I | -0.041231 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0409599 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.04052 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0401335 |
| JUN | jun proto-oncogene | -0.0394063 |
| ASPH | aspartate beta-hydroxylase | -0.0387875 |
| ENO1 | enolase 1, (alpha) | -0.0387602 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.03848 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0382842 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0382763 |
| HM13 | histocompatibility (minor) 13 | -0.0367983 |
| CENPF | centromere protein F, 350/400kDa | -0.0366491 |
| RAB10 | RAB10, member RAS oncogene family | -0.0360129 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0357412 |
| THOC2 | THO complex 2 | -0.0353405 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0353354 |
| HKDC1 | hexokinase domain containing 1 | -0.0351117 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0350619 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.034884 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0346857 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0345375 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.034309 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0339439 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0332333 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0331882 |
| MMP7 | matrix metallopeptidase 7 | -0.0331528 |
| TMEM123 | transmembrane protein 123 | -0.03314 |
| ABLIM1 | actin binding LIM protein 1 | -0.0328735 |
| S100A10 | S100 calcium binding protein A10 | -0.0328324 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0327336 |
| ACTN4 | actinin, alpha 4 | -0.0325344 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.032344 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0322566 |
| TES | testin LIM domain protein | -0.0322391 |
| DIAPH2 | diaphanous-related formin 2 | -0.032031 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0318438 |
| PYGB | phosphorylase, glycogen; brain | -0.0318043 |
| HMGB1 | high mobility group box 1 | -0.0316619 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0315169 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0314978 |
| TPM4 | tropomyosin 4 | -0.0314244 |
| FLNB | filamin B, beta | -0.030949 |
| ITGA6 | integrin, alpha 6 | -0.0308611 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0308317 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0306921 |
| GOLGA4 | golgin A4 | -0.0305345 |
| TM4SF4 | transmembrane 4 L six family member 4 | -0.0302705 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.030191 |
| KLK10 | kallikrein-related peptidase 10 | -0.0301563 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0300589 |
| ACTG1 | actin gamma 1 | -0.0298982 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0297164 |
| CLTC | clathrin, heavy chain (Hc) | -0.0296532 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0294693 |
