| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.124284 |
| IGF2 | insulin-like growth factor 2 | 0.123983 |
| SVIL | supervillin | 0.120913 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.095645 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0944234 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0668709 |
| C3 | complement component 3 | 0.0648031 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0585153 |
| FN1 | fibronectin 1 | 0.058344 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0530863 |
| APOB | apolipoprotein B | 0.04708 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0457552 |
| CRY1 | cryptochrome circadian clock 1 | 0.0454095 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0425944 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0412892 |
| FAT1 | FAT atypical cadherin 1 | 0.0397995 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0390199 |
| NDRG1 | N-myc downstream regulated 1 | 0.0386129 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0383564 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0378532 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0340254 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.031473 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.029808 |
| TNS1 | tensin 1 | 0.0297911 |
| FOXP1 | forkhead box P1 | 0.0294242 |
| FAM107B | family with sequence similarity 107, member B | 0.0287477 |
| HMGA1 | high mobility group AT-hook 1 | 0.0277251 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0276608 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0258975 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0258044 |
| DSTN | destrin (actin depolymerizing factor) | 0.0256957 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.023706 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0236444 |
| DTNA | dystrobrevin, alpha | 0.0226227 |
| PCBP2 | poly(rC) binding protein 2 | 0.0225044 |
| POTEF | POTE ankyrin domain family, member F | 0.0219966 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0218413 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0216753 |
| KYNU | kynureninase | 0.0214052 |
| TXNRD1 | thioredoxin reductase 1 | 0.0212686 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0211261 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0209507 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0208992 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0202864 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0200634 |
| CFB | complement factor B | 0.0197604 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0197456 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0197254 |
| USP47 | ubiquitin specific peptidase 47 | 0.0189686 |
| CCN2 | cellular communication network factor 2 | 0.0189501 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0186832 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0186786 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0185318 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0184615 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.018115 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0179448 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.0175097 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0173966 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0173249 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0171836 |
| ARRDC3 | arrestin domain containing 3 | 0.0171739 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0171227 |
| MYADM | myeloid-associated differentiation marker | 0.0167307 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0166755 |
| LDHA | lactate dehydrogenase A | 0.0166541 |
| NUP58 | nucleoporin 58 | 0.016467 |
| RPL3 | ribosomal protein L3 | 0.0164527 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0164407 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.016328 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0163052 |
| PER2 | period circadian clock 2 | 0.0160446 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0159619 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0159516 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.015889 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0155836 |
| EZR | ezrin | 0.0155494 |
| FHL2 | four and a half LIM domains 2 | 0.0155392 |
| RPS7 | ribosomal protein S7 | 0.0155348 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0154148 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0154142 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0152076 |
| VEGFA | vascular endothelial growth factor A | 0.0151561 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0149884 |
| USP6NL | USP6 N-terminal like | 0.0149443 |
| MYO1B | myosin IB | 0.0149426 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0147572 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0146488 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0145088 |
| FAM13A | family with sequence similarity 13, member A | 0.0141572 |
| TLE4 | transducin-like enhancer of split 4 | 0.0140831 |
| UBN2 | ubinuclein 2 | 0.0139039 |
| KIAA1217 | KIAA1217 | 0.0138245 |
| TCIM | transcriptional and immune response regulator | 0.0135706 |
| GSE1 | Gse1 coiled-coil protein | 0.0135155 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0134665 |
| RASA2 | RAS p21 protein activator 2 | 0.0134597 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0133672 |
| AFDN | afadin, adherens junction formation factor | 0.0132555 |
| PRELID2 | PRELI domain containing 2 | 0.0131763 |
| KALRN | kalirin, RhoGEF kinase | 0.013157 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.19152 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.126373 |
| GPC3 | glypican 3 | -0.12236 |
| EHBP1 | EH domain binding protein 1 | -0.0937013 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0809309 |
| RPS24 | ribosomal protein S24 | -0.076346 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0757549 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0711685 |
| CP | ceruloplasmin (ferroxidase) | -0.0636116 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0605077 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.058527 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0580917 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0557385 |
| GNAS | GNAS complex locus | -0.0522393 |
| RPL11 | ribosomal protein L11 | -0.0512574 |
| GPC6 | glypican 6 | -0.048178 |
| TRIM26 | tripartite motif containing 26 | -0.0465187 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0460927 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0442097 |
| RPL37A | ribosomal protein L37a | -0.0441577 |
| RPLP1 | ribosomal protein, large, P1 | -0.0433683 |
| APOA2 | apolipoprotein A-II | -0.0430592 |
| AHSG | alpha-2-HS-glycoprotein | -0.0426556 |
| RPL26 | ribosomal protein L26 | -0.041736 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0409971 |
| RPS12 | ribosomal protein S12 | -0.0405312 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0403875 |
| RPS6 | ribosomal protein S6 | -0.0402591 |
| RPL35A | ribosomal protein L35a | -0.0390985 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0388644 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0388361 |
| PTCHD4 | patched domain containing 4 | -0.0386982 |
| VCL | vinculin | -0.0382151 |
| ASPH | aspartate beta-hydroxylase | -0.0377187 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0376185 |
| PEG3 | paternally expressed 3 | -0.0375728 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0373888 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0363558 |
| RPLP0 | ribosomal protein, large, P0 | -0.0360572 |
| RBM39 | RNA binding motif protein 39 | -0.0360126 |
| NPR2 | natriuretic peptide receptor 2 | -0.0342243 |
| PHF3 | PHD finger protein 3 | -0.0339718 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.033802 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0331982 |
| IER3 | immediate early response 3 | -0.0329231 |
| RPS27A | ribosomal protein S27a | -0.0328995 |
| RRBP1 | ribosome binding protein 1 | -0.0327912 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0323976 |
| TMEM123 | transmembrane protein 123 | -0.0318803 |
| RIGI | RNA sensor RIG-I | -0.0318613 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0313993 |
| RPS3 | ribosomal protein S3 | -0.0310647 |
| FTL | ferritin, light polypeptide | -0.0308224 |
| RPLP2 | ribosomal protein, large, P2 | -0.0302528 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0302359 |
| RPS19 | ribosomal protein S19 | -0.0301784 |
| SDC4 | syndecan 4 | -0.0295204 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0291959 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0291544 |
| PLIN2 | perilipin 2 | -0.0289311 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0287207 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0284382 |
| RBM25 | RNA binding motif protein 25 | -0.028424 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0284227 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0277606 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0274724 |
| MT2A | metallothionein 2A | -0.0274371 |
| RPS21 | ribosomal protein S21 | -0.0268802 |
| RPL9 | ribosomal protein L9 | -0.0267688 |
| RPS8 | ribosomal protein S8 | -0.026635 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.026561 |
| RPL34 | ribosomal protein L34 | -0.0262548 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0262064 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0254712 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0251785 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0251782 |
| RNF213 | ring finger protein 213 | -0.0251451 |
| EGR1 | early growth response 1 | -0.0247084 |
| RACK1 | receptor for activated C kinase 1 | -0.0246732 |
| FRMD5 | FERM domain containing 5 | -0.0241432 |
| FMNL2 | formin-like 2 | -0.023617 |
| RPL37 | ribosomal protein L37 | -0.0235445 |
| RPL12 | ribosomal protein L12 | -0.0234832 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0234153 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0234119 |
| RPS23 | ribosomal protein S23 | -0.0234045 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0229895 |
| INTS6 | integrator complex subunit 6 | -0.0225897 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.022565 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0225178 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0223493 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0219833 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0216563 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0213524 |
| ZFHX3 | zinc finger homeobox 3 | -0.0211971 |
| RPS16 | ribosomal protein S16 | -0.021175 |
| CANX | calnexin | -0.0209974 |
| RPL14 | ribosomal protein L14 | -0.020752 |
| RPL38 | ribosomal protein L38 | -0.0205922 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0204261 |
