| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.213622 |
| MT2A | metallothionein 2A | 0.146625 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0574831 |
| SMAD3 | SMAD family member 3 | 0.0550178 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0472603 |
| FLNB | filamin B, beta | 0.0463728 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0463189 |
| FOSL1 | FOS-like antigen 1 | 0.042172 |
| RPS3 | ribosomal protein S3 | 0.0400895 |
| RPL26 | ribosomal protein L26 | 0.0397704 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0393375 |
| HLA-B | major histocompatibility complex, class I, B | 0.0388854 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0383219 |
| HMGA1 | high mobility group AT-hook 1 | 0.0345909 |
| ANXA1 | annexin A1 | 0.0332006 |
| FLNA | filamin A, alpha | 0.0324528 |
| RPL35A | ribosomal protein L35a | 0.0323107 |
| RPS12 | ribosomal protein S12 | 0.0290213 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0289061 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.028424 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0272091 |
| STC2 | stanniocalcin 2 | 0.0269712 |
| RPL5 | ribosomal protein L5 | 0.0262002 |
| GANAB | glucosidase, alpha; neutral AB | 0.025704 |
| NAV2 | neuron navigator 2 | 0.0250131 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0248531 |
| RPL13A | ribosomal protein L13a | 0.0236893 |
| PCBP2 | poly(rC) binding protein 2 | 0.023481 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0234487 |
| PODXL | podocalyxin-like | 0.0234197 |
| SEPTIN9 | septin 9 | 0.0232186 |
| RPS13 | ribosomal protein S13 | 0.0225348 |
| NCOR2 | nuclear receptor corepressor 2 | 0.022483 |
| PTK2 | protein tyrosine kinase 2 | 0.0224142 |
| RND3 | Rho family GTPase 3 | 0.0222876 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0222859 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0219292 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0217441 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0216217 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0210983 |
| FAM107B | family with sequence similarity 107, member B | 0.0210374 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0210078 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0208014 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0207202 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0204931 |
| RPS8 | ribosomal protein S8 | 0.0202632 |
| MSN | moesin | 0.0201998 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0200341 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0199079 |
| ANKRD28 | ankyrin repeat domain 28 | 0.01982 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0197342 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0196351 |
| RPL37A | ribosomal protein L37a | 0.0193924 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0190044 |
| TPM3 | tropomyosin 3 | 0.0188955 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0188795 |
| MLF1 | myeloid leukemia factor 1 | 0.0188259 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0187391 |
| MCL1 | myeloid cell leukemia 1 | 0.0181373 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0175347 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0174337 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0174335 |
| RPL23 | ribosomal protein L23 | 0.0173514 |
| RPLP2 | ribosomal protein, large, P2 | 0.0168625 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0167067 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0166344 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0163278 |
| NCKAP1 | NCK-associated protein 1 | 0.016245 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0161707 |
| ARRDC3 | arrestin domain containing 3 | 0.016152 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0160632 |
| RUNX1 | runt-related transcription factor 1 | 0.0158638 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.015604 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.015488 |
| GATA2 | GATA binding protein 2 | 0.0153745 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0153332 |
| TUFT1 | tuftelin 1 | 0.0151427 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0150024 |
| ZNF462 | zinc finger protein 462 | 0.0146297 |
| FAM219A | family with sequence similarity 219, member A | 0.0143769 |
| RPL7A | ribosomal protein L7a | 0.0142233 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0141731 |
| RPL35 | ribosomal protein L35 | 0.0140735 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0140393 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0140249 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0138922 |
| TFRC | transferrin receptor | 0.0138257 |
| EFNA5 | ephrin-A5 | 0.0137504 |
| RPL27 | ribosomal protein L27 | 0.0137103 |
| PDE10A | phosphodiesterase 10A | 0.0136751 |
| RPL28 | ribosomal protein L28 | 0.013539 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0135374 |
| ATF3 | activating transcription factor 3 | 0.0135241 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0135197 |
| RPS15A | ribosomal protein S15a | 0.0134321 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0134248 |
| PLEC | plectin | 0.0133239 |
| RASA3 | RAS p21 protein activator 3 | 0.0128239 |
| COL3A1 | collagen, type III, alpha 1 | 0.0128095 |
| RPS2 | ribosomal protein S2 | 0.0127687 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.270415 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.194026 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.16701 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.114555 |
| FTL | ferritin, light polypeptide | -0.102546 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0948967 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0920466 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.076515 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0648747 |
| PTMA | prothymosin, alpha | -0.0591796 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.055644 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0544442 |
| TMSB10 | thymosin beta 10 | -0.0539907 |
| CANX | calnexin | -0.0497945 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0486142 |
| DEK | DEK proto-oncogene | -0.0483778 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0474964 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0467782 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0465976 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0452384 |
| VIM | vimentin | -0.0438322 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0429942 |
| PLIN2 | perilipin 2 | -0.0423702 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0422347 |
| GLIS3 | GLIS family zinc finger 3 | -0.0418688 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0410721 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0407311 |
| DIAPH3 | diaphanous-related formin 3 | -0.0404595 |
| VCL | vinculin | -0.0401849 |
| TPM4 | tropomyosin 4 | -0.0396598 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0388408 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0381971 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0379288 |
| ANXA2 | annexin A2 | -0.0377456 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0376201 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.037478 |
| TMSB4X | thymosin beta 4, X-linked | -0.0370434 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.035784 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0355562 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0348603 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0344752 |
| CAVIN1 | caveolae associated protein 1 | -0.0336815 |
| RAI14 | retinoic acid induced 14 | -0.0304626 |
| GNAS | GNAS complex locus | -0.0298331 |
| POSTN | periostin, osteoblast specific factor | -0.0289332 |
| COL5A2 | collagen, type V, alpha 2 | -0.0288485 |
| MAP1B | microtubule-associated protein 1B | -0.0285624 |
| AHNAK | AHNAK nucleoprotein | -0.0280927 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0277151 |
| ZNF804A | zinc finger protein 804A | -0.0273781 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0271204 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0270479 |
| PLCB4 | phospholipase C, beta 4 | -0.0269716 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0267143 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0266682 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0266211 |
| S100A6 | S100 calcium binding protein A6 | -0.0265294 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0261533 |
| PKM | pyruvate kinase, muscle | -0.0257667 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0257421 |
| OSMR | oncostatin M receptor | -0.0257409 |
| TUBB | tubulin, beta class I | -0.0251624 |
| MMP12 | matrix metallopeptidase 12 | -0.0251556 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0250684 |
| IL6ST | interleukin 6 signal transducer | -0.0248293 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0245552 |
| TPM1 | tropomyosin 1 (alpha) | -0.0242984 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0239936 |
| RIOK3 | RIO kinase 3 | -0.0238641 |
| MAP4 | microtubule-associated protein 4 | -0.0237386 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0236964 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0235863 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0235013 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0232824 |
| SBF2 | SET binding factor 2 | -0.0230784 |
| COPA | coatomer protein complex, subunit alpha | -0.0228653 |
| LOX | lysyl oxidase | -0.0228296 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0227473 |
| THRAP3 | thyroid hormone receptor associated protein 3 | -0.0223406 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0223224 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0219876 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0219107 |
| TPI1 | triosephosphate isomerase 1 | -0.0218883 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0216812 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0216552 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0216493 |
| VDAC1 | voltage-dependent anion channel 1 | -0.021161 |
| DST | dystonin | -0.0208028 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0207142 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0206749 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0206742 |
| ITGA1 | integrin, alpha 1 | -0.020662 |
| SULF1 | sulfatase 1 | -0.0206054 |
| CBX3 | chromobox homolog 3 | -0.020216 |
| TPX2 | TPX2, microtubule-associated | -0.0199342 |
| RBM39 | RNA binding motif protein 39 | -0.0199254 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0198143 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0197608 |
| TNS3 | tensin 3 | -0.019686 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0195438 |
