| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.137068 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.112032 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.111847 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.111018 |
| EMP1 | epithelial membrane protein 1 | 0.110614 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0696357 |
| ANXA2 | annexin A2 | 0.0692447 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0657716 |
| SEPTIN9 | septin 9 | 0.0600212 |
| ASPH | aspartate beta-hydroxylase | 0.0582268 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0522714 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0516582 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0507637 |
| INTS6 | integrator complex subunit 6 | 0.0486371 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0476393 |
| MCU | mitochondrial calcium uniporter | 0.0452215 |
| ANXA1 | annexin A1 | 0.0449562 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.04494 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0449307 |
| TMC5 | transmembrane channel-like 5 | 0.0445918 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0442713 |
| MYO1E | myosin IE | 0.0442476 |
| EFNB2 | ephrin-B2 | 0.0433876 |
| HSPA8 | heat shock 70kDa protein 8 | 0.043034 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0414377 |
| RPL26 | ribosomal protein L26 | 0.041398 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.041307 |
| ATXN1 | ataxin 1 | 0.0405327 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0394176 |
| TJP1 | tight junction protein 1 | 0.038931 |
| GDA | guanine deaminase | 0.0386933 |
| FLNB | filamin B, beta | 0.0385856 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0383107 |
| FAT1 | FAT atypical cadherin 1 | 0.0380182 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0370608 |
| CAPN8 | calpain 8 | 0.0369831 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0368819 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0365249 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0364021 |
| SMAD3 | SMAD family member 3 | 0.0350414 |
| MYOF | myoferlin | 0.0348593 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0345004 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0341251 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.033967 |
| S100P | S100 calcium binding protein P | 0.0339367 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0336414 |
| EFNA5 | ephrin-A5 | 0.032987 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0328608 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0319613 |
| AHR | aryl hydrocarbon receptor | 0.0317358 |
| PLEC | plectin | 0.0311079 |
| RPS3 | ribosomal protein S3 | 0.0309559 |
| RPS12 | ribosomal protein S12 | 0.0299392 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0292068 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0291226 |
| VMP1 | vacuole membrane protein 1 | 0.0289488 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0289335 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0286484 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0276612 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0270266 |
| LAMA4 | laminin, alpha 4 | 0.0267591 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.026522 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.026503 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0262733 |
| KLHL29 | kelch-like family member 29 | 0.0257635 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0256646 |
| HMGA1 | high mobility group AT-hook 1 | 0.0254141 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0252816 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0252343 |
| KRT86 | keratin 86, type II | 0.025189 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0249755 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | 0.0246749 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0245609 |
| SGMS2 | sphingomyelin synthase 2 | 0.0241424 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0241339 |
| RPL37A | ribosomal protein L37a | 0.0241222 |
| POF1B | premature ovarian failure, 1B | 0.0239763 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0237058 |
| RPS25 | ribosomal protein S25 | 0.023703 |
| SNX9 | sorting nexin 9 | 0.0236099 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0235559 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0231627 |
| RASEF | RAS and EF-hand domain containing | 0.0227972 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0226763 |
| EHBP1 | EH domain binding protein 1 | 0.0226741 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0221158 |
| SIK3 | SIK family kinase 3 | 0.0220256 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0216514 |
| TGFA | transforming growth factor, alpha | 0.0215479 |
| AREG | amphiregulin | 0.021401 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0213882 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0211449 |
| RNF213 | ring finger protein 213 | 0.0210434 |
| BCL2L1 | BCL2-like 1 | 0.0210355 |
| MCL1 | myeloid cell leukemia 1 | 0.0209481 |
| FOXO3 | forkhead box O3 | 0.0205627 |
| RPL6 | ribosomal protein L6 | 0.0204557 |
| RPL13A | ribosomal protein L13a | 0.0203023 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0202887 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0201181 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.175533 |
| PTMA | prothymosin, alpha | -0.141695 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.102289 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.0953006 |
| TMSB10 | thymosin beta 10 | -0.0823024 |
| RPS6 | ribosomal protein S6 | -0.0820497 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0712518 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0574639 |
| RPLP1 | ribosomal protein, large, P1 | -0.0554132 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0553287 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.053308 |
| FTL | ferritin, light polypeptide | -0.0479667 |
| CDK6 | cyclin-dependent kinase 6 | -0.0471908 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0465672 |
| GOLGA4 | golgin A4 | -0.0460881 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0458222 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.041301 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0407588 |
| WDR45B | WD repeat domain 45B | -0.0401908 |
| TMEM123 | transmembrane protein 123 | -0.039812 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0398043 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0391034 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0381038 |
| TES | testin LIM domain protein | -0.036711 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0361397 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0360435 |
| CBX3 | chromobox homolog 3 | -0.0357473 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0352148 |
| KRT18 | keratin 18, type I | -0.0348013 |
| PKM | pyruvate kinase, muscle | -0.0346577 |
| S100A6 | S100 calcium binding protein A6 | -0.0343517 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.033049 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0328515 |
| DEK | DEK proto-oncogene | -0.0324613 |
| RBM39 | RNA binding motif protein 39 | -0.0319342 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.031192 |
| CD46 | CD46 molecule, complement regulatory protein | -0.031 |
| XPO1 | exportin 1 | -0.0308629 |
| RRBP1 | ribosome binding protein 1 | -0.0307566 |
| VEGFA | vascular endothelial growth factor A | -0.0298555 |
| ZNF292 | zinc finger protein 292 | -0.0297123 |
| AGR2 | anterior gradient 2 | -0.0296354 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0294085 |
| CANX | calnexin | -0.0291692 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0291156 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0290191 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0289425 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0284885 |
| HMGB1 | high mobility group box 1 | -0.027897 |
| ANLN | anillin, actin binding protein | -0.0278176 |
| ATF5 | activating transcription factor 5 | -0.0276773 |
| RSF1 | remodeling and spacing factor 1 | -0.0266507 |
| B2M | beta-2-microglobulin | -0.0265353 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0262372 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0261955 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0261182 |
| CLDN7 | claudin 7 | -0.0258077 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0256331 |
| SET | SET nuclear proto-oncogene | -0.0256053 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0256005 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0255216 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.025485 |
| RBM25 | RNA binding motif protein 25 | -0.0250679 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0244628 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0235915 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0234589 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0233542 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0231876 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0230636 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0230011 |
| RPLP0 | ribosomal protein, large, P0 | -0.022925 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0226561 |
| PCM1 | pericentriolar material 1 | -0.022563 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0225417 |
| TRAM1 | translocation associated membrane protein 1 | -0.02237 |
| GNAS | GNAS complex locus | -0.0221215 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0221096 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0220716 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0220162 |
| ADD3 | adducin 3 (gamma) | -0.0219193 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0218086 |
| THOC2 | THO complex 2 | -0.021734 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0215294 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0213758 |
| NDRG1 | N-myc downstream regulated 1 | -0.0213735 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0213108 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0210889 |
| LYZ | lysozyme | -0.0210477 |
| CENPF | centromere protein F, 350/400kDa | -0.0210016 |
| ENO1 | enolase 1, (alpha) | -0.0209878 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0209824 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0206775 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | -0.0206457 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0206452 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0205213 |
| CEP57 | centrosomal protein 57kDa | -0.0201759 |
| DIAPH3 | diaphanous-related formin 3 | -0.0200309 |
| SETD5 | SET domain containing 5 | -0.0199383 |
| RPS4X | ribosomal protein S4, X-linked | -0.0197233 |
| RPL19 | ribosomal protein L19 | -0.0195561 |
