Lapatinib ditosylate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.171425
RPS12 ribosomal protein S12 0.0793727
TPT1 tumor protein, translationally-controlled 1 0.0773807
RPL26 ribosomal protein L26 0.0558767
RPS3 ribosomal protein S3 0.0443016
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0437257
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0429223
PIGR polymeric immunoglobulin receptor 0.0414494
AREG amphiregulin 0.0411242
RPS8 ribosomal protein S8 0.0406549
RPL13A ribosomal protein L13a 0.0404062
NEBL nebulette 0.0396146
HSPA8 heat shock 70kDa protein 8 0.0396054
RPL37A ribosomal protein L37a 0.0385661
AFF1 AF4/FMR2 family, member 1 0.0378471
RPL35A ribosomal protein L35a 0.0325742
VEGFA vascular endothelial growth factor A 0.0320117
TGFBR3 transforming growth factor, beta receptor III 0.0305648
EEF1G eukaryotic translation elongation factor 1 gamma 0.0277368
RPS29 ribosomal protein S29 0.0276242
ATXN1 ataxin 1 0.0262234
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0261269
SQSTM1 sequestosome 1 0.0242167
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0241522
RPS2 ribosomal protein S2 0.0228752
WHRN whirlin 0.0224003
RPL6 ribosomal protein L6 0.0221924
RPL36 ribosomal protein L36 0.0220885
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0218776
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0213433
RPS27A ribosomal protein S27a 0.0212259
RPL9 ribosomal protein L9 0.0209038
RPL5 ribosomal protein L5 0.0208891
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0197698
MUC13 mucin 13, cell surface associated 0.0195073
RPS13 ribosomal protein S13 0.0194714
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.019392
PDZD8 PDZ domain containing 8 0.0192855
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0192809
USP6NL USP6 N-terminal like 0.0191601
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0190409
UNC13B unc-13 homolog B (C. elegans) 0.0189135
RPL11 ribosomal protein L11 0.01837
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0181616
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0180527
GANAB glucosidase, alpha; neutral AB 0.017147
EEF2 eukaryotic translation elongation factor 2 0.0170641
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0168886
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.01664
TXNIP thioredoxin interacting protein 0.0159077
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0159054
CEMIP2 cell migration inducing hyaluronidase 2 0.0157294
EXPH5 exophilin 5 0.0156035
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.0155428
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0155188
RPS10 ribosomal protein S10 0.0154407
RPL23 ribosomal protein L23 0.0154185
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.014875
VASP vasodilator-stimulated phosphoprotein 0.0148265
EXT1 exostosin glycosyltransferase 1 0.0145257
RPS27 ribosomal protein S27 0.0144767
RPL3 ribosomal protein L3 0.014393
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0143426
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0142373
DDIT4 DNA-damage-inducible transcript 4 0.0141671
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0139351
CEMIP cell migration inducing protein, hyaluronan binding 0.0137922
DUSP16 dual specificity phosphatase 16 0.0132644
UBE2H ubiquitin-conjugating enzyme E2H 0.0132021
STC2 stanniocalcin 2 0.013172
LURAP1L leucine rich adaptor protein 1-like 0.0131441
AFDN afadin, adherens junction formation factor 0.0131333
RPL28 ribosomal protein L28 0.0131164
BBS9 Bardet-Biedl syndrome 9 0.0131076
RPLP2 ribosomal protein, large, P2 0.0130658
TMEM59 transmembrane protein 59 0.0130562
CRY1 cryptochrome circadian clock 1 0.0129119
HSPE1 heat shock 10kDa protein 1 0.0129017
CYSTM1 cysteine-rich transmembrane module containing 1 0.0128479
GDA guanine deaminase 0.012768
NCKAP1 NCK-associated protein 1 0.012707
SHROOM3 shroom family member 3 0.0125463
PCBP2 poly(rC) binding protein 2 0.012432
RPS23 ribosomal protein S23 0.0124316
RPL36A ribosomal protein L36a 0.0123795
RPS7 ribosomal protein S7 0.0123365
RPS15A ribosomal protein S15a 0.0122406
B2M beta-2-microglobulin 0.0120448
ADGRV1 adhesion G protein-coupled receptor V1 0.0119086
EIF4B eukaryotic translation initiation factor 4B 0.0118109
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0117318
EPHB2 EPH receptor B2 0.0112723
PRKCSH protein kinase C substrate 80K-H 0.0111029
PER2 period circadian clock 2 0.0110454
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0108879
RPS11 ribosomal protein S11 0.01075
SIK3 SIK family kinase 3 0.0105974
ATF3 activating transcription factor 3 0.0105001
RPS17 ribosomal protein S17 0.0104259
CASZ1 castor zinc finger 1 0.0103222

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.356039
NPSR1 neuropeptide S receptor 1 -0.257247
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.184142
TMSB10 thymosin beta 10 -0.176188
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.140247
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127672
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.108549
ANXA2 annexin A2 -0.0984058
KRT18 keratin 18, type I -0.0945776
ALCAM activated leukocyte cell adhesion molecule -0.0883676
FLNB filamin B, beta -0.0850526
ITGA6 integrin, alpha 6 -0.0814869
AHNAK AHNAK nucleoprotein -0.0811832
S100A6 S100 calcium binding protein A6 -0.0788745
GREB1L growth regulation by estrogen in breast cancer-like -0.0788151
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0733
TPM4 tropomyosin 4 -0.0725733
ANTXR2 anthrax toxin receptor 2 -0.0702701
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0694852
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0687927
VCL vinculin -0.0642201
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0623475
RPLP1 ribosomal protein, large, P1 -0.0623136
NALF1 NALCN channel auxiliary factor 1 -0.0605778
SLC35F3 solute carrier family 35, member F3 -0.0573748
ASPH aspartate beta-hydroxylase -0.0555648
PKM pyruvate kinase, muscle -0.0516806
PSD3 pleckstrin and Sec7 domain containing 3 -0.0511381
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0504115
RNF217 ring finger protein 217 -0.0483203
GMDS GDP-mannose 4,6-dehydratase -0.0471757
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0464063
CALB1 calbindin 1, 28kDa -0.0454935
LAMA4 laminin, alpha 4 -0.0453902
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0438501
FERMT1 fermitin family member 1 -0.043366
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0431403
ONECUT3 one cut homeobox 3 -0.0416568
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0416212
H1-0 H1.0 linker histone -0.0410303
ACTG1 actin gamma 1 -0.0402887
RAB10 RAB10, member RAS oncogene family -0.0400318
EHBP1 EH domain binding protein 1 -0.0398836
SOX4 SRY (sex determining region Y)-box 4 -0.0392337
GCC2 GRIP and coiled-coil domain containing 2 -0.0389288
RPS6 ribosomal protein S6 -0.0381067
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0375087
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0374773
MAML2 mastermind-like 2 (Drosophila) -0.0371626
BZW1 basic leucine zipper and W2 domains 1 -0.0365559
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0358822
DIAPH2 diaphanous-related formin 2 -0.0347112
NRN1 neuritin 1 -0.0345981
PATJ PATJ crumbs cell polarity complex component -0.0341235
KRT8 keratin 8, type II -0.0338441
DLG1 discs, large homolog 1 (Drosophila) -0.0336183
MUC17 mucin 17, cell surface associated -0.0332792
ABLIM1 actin binding LIM protein 1 -0.0332785
PPARG peroxisome proliferator-activated receptor gamma -0.0332709
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0331141
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0329771
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.032885
PDIA3 protein disulfide isomerase family A, member 3 -0.0327926
RPS24 ribosomal protein S24 -0.0327756
MLEC malectin -0.0326056
HDLBP high density lipoprotein binding protein -0.0323924
DENND1A DENN/MADD domain containing 1A -0.0322289
CCND1 cyclin D1 -0.0318654
EZR ezrin -0.0317936
ARHGAP5 Rho GTPase activating protein 5 -0.0316089
RPLP0 ribosomal protein, large, P0 -0.0315645
KIF5B kinesin family member 5B -0.0314406
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0314218
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0313493
F3 coagulation factor III (thromboplastin, tissue factor) -0.0313311
BIRC6 baculoviral IAP repeat containing 6 -0.0302554
PERP PERP, TP53 apoptosis effector -0.0298743
ARHGAP6 Rho GTPase activating protein 6 -0.0295684
RAP1B RAP1B, member of RAS oncogene family -0.0293708
ITPRID2 ITPR interacting domain containing 2 -0.0293473
IER3 immediate early response 3 -0.0291418
KLK10 kallikrein-related peptidase 10 -0.0288569
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0287114
SBF2 SET binding factor 2 -0.0285061
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0283763
PGK1 phosphoglycerate kinase 1 -0.0282817
DSG2 desmoglein 2 -0.0282814
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0280671
HDAC2 histone deacetylase 2 -0.0280183
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0274307
MYOF myoferlin -0.0271775
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.027017
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0269259
S100A10 S100 calcium binding protein A10 -0.0267944
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0266833
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0266454
PDLIM5 PDZ and LIM domain 5 -0.0262451
ESYT2 extended synaptotagmin-like protein 2 -0.0260155
BTG1 B-cell translocation gene 1, anti-proliferative -0.0258352
LPP LIM domain containing preferred translocation partner in lipoma -0.0255958