Lapatinib ditosylate_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.168979
RPS12 ribosomal protein S12 0.103825
HSPA8 heat shock 70kDa protein 8 0.0791713
INTS6 integrator complex subunit 6 0.0689082
RPL26 ribosomal protein L26 0.064256
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0630721
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0533532
RPS3 ribosomal protein S3 0.0529402
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.051793
RPL37A ribosomal protein L37a 0.0497567
CTBP2 C-terminal binding protein 2 0.0479626
EXT1 exostosin glycosyltransferase 1 0.0473268
MYO1E myosin IE 0.0464298
CCSER1 coiled-coil serine-rich protein 1 0.0455806
RIMKLB ribosomal modification protein rimK-like family member B 0.04367
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0435302
ZSWIM6 zinc finger, SWIM-type containing 6 0.0433445
PTPRG protein tyrosine phosphatase, receptor type, G 0.0405289
ARHGAP26 Rho GTPase activating protein 26 0.0395302
SQSTM1 sequestosome 1 0.0383007
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0378617
RPL13A ribosomal protein L13a 0.0355168
PARD3B par-3 family cell polarity regulator beta 0.0335762
RPS8 ribosomal protein S8 0.033388
LPP LIM domain containing preferred translocation partner in lipoma 0.0319128
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.03182
LOC105378220 macrophage receptor MARCO-like 0.0316954
LRRC23 leucine rich repeat containing 23 0.0315665
CATSPERB catsper channel auxiliary subunit beta 0.0314307
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0313148
FRMD5 FERM domain containing 5 0.030854
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0307918
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0305283
FAT1 FAT atypical cadherin 1 0.0304765
SPON1 spondin 1, extracellular matrix protein 0.0303066
SLC38A2 solute carrier family 38, member 2 0.0299497
RPL6 ribosomal protein L6 0.0297679
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0292272
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0288874
SMYD3 SET and MYND domain containing 3 0.0278635
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0278353
LGALS12 lectin, galactoside-binding, soluble, 12 0.0271353
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.027027
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0264076
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0263752
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0263463
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.026103
HSPH1 heat shock 105kDa/110kDa protein 1 0.0260921
MPRIP myosin phosphatase Rho interacting protein 0.0260855
EGFR epidermal growth factor receptor 0.0260546
EXOC4 exocyst complex component 4 0.0255364
RPS2 ribosomal protein S2 0.0250875
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.0246427
GRB10 growth factor receptor-bound protein 10 0.0244914
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0243993
ANXA2 annexin A2 0.0237145
TFRC transferrin receptor 0.0236323
DSPP dentin sialophosphoprotein 0.0231657
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.022832
ARL15 ADP-ribosylation factor-like 15 0.0228144
RPS27A ribosomal protein S27a 0.0226014
FBXL17 F-box and leucine-rich repeat protein 17 0.0225844
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0225334
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0224975
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0224435
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0223761
RACK1 receptor for activated C kinase 1 0.0216176
PDZD8 PDZ domain containing 8 0.0214527
ASPH aspartate beta-hydroxylase 0.0214417
IGF1R insulin-like growth factor 1 receptor 0.0214221
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0210935
MTAP methylthioadenosine phosphorylase 0.0208461
GMDS GDP-mannose 4,6-dehydratase 0.0208304
NABP1 nucleic acid binding protein 1 0.0206461
IFRD1 interferon-related developmental regulator 1 0.0206
MYO5B myosin VB 0.0205556
KDM3B lysine (K)-specific demethylase 3B 0.0204091
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0203402
RPS25 ribosomal protein S25 0.0202163
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0197264
HLA-C major histocompatibility complex, class I, C 0.0196201
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0195373
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.019455
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0193046
TRAPPC9 trafficking protein particle complex 9 0.0192884
TC2N tandem C2 domains, nuclear 0.019267
RCC1 regulator of chromosome condensation 1 0.0190821
AEBP2 AE binding protein 2 0.0190402
IFI6 interferon, alpha-inducible protein 6 0.0187706
SND1 staphylococcal nuclease and tudor domain containing 1 0.0187458
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0186123
PDE4D phosphodiesterase 4D, cAMP-specific 0.0184942
EEF1G eukaryotic translation elongation factor 1 gamma 0.0184416
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0184256
APLP2 amyloid beta (A4) precursor-like protein 2 0.0184042
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0183827
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0183755
ERRFI1 ERBB receptor feedback inhibitor 1 0.0183423
OSBPL10 oxysterol binding protein-like 10 0.0183058
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0182749

decreased expression

Symbol Name Standardized Value
RPLP1 ribosomal protein, large, P1 -0.227821
TMSB10 thymosin beta 10 -0.13496
RPS6 ribosomal protein S6 -0.134808
PTMA prothymosin, alpha -0.109999
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.094863
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0817821
GOLGA4 golgin A4 -0.0620693
RPS19 ribosomal protein S19 -0.0615375
RPLP0 ribosomal protein, large, P0 -0.0614043
RBM25 RNA binding motif protein 25 -0.0574991
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0555046
RPL34 ribosomal protein L34 -0.0528348
PTPRR protein tyrosine phosphatase, receptor type, R -0.0507108
CALB1 calbindin 1, 28kDa -0.0502657
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0479344
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.046288
RRBP1 ribosome binding protein 1 -0.0455349
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.043788
GARS1 glycyl-tRNA synthetase 1 -0.0437806
RPL32 ribosomal protein L32 -0.0436133
S100A6 S100 calcium binding protein A6 -0.042376
PDIA3 protein disulfide isomerase family A, member 3 -0.0407243
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0406741
PLAC8 placenta-specific 8 -0.0403869
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0397664
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.039644
ACTG1 actin gamma 1 -0.0389716
GCC2 GRIP and coiled-coil domain containing 2 -0.0359522
ESYT2 extended synaptotagmin-like protein 2 -0.0355264
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0352092
F3 coagulation factor III (thromboplastin, tissue factor) -0.0348827
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0346082
RPL31 ribosomal protein L31 -0.0341252
POTEF POTE ankyrin domain family, member F -0.0339705
RPS5 ribosomal protein S5 -0.0337439
GDF15 growth differentiation factor 15 -0.0336976
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0332296
RPL12 ribosomal protein L12 -0.0328931
PKM pyruvate kinase, muscle -0.0320365
ITGA6 integrin, alpha 6 -0.0317849
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0316444
PRRC2C proline-rich coiled-coil 2C -0.0310916
TXNRD1 thioredoxin reductase 1 -0.0303274
RPS24 ribosomal protein S24 -0.030053
MYOF myoferlin -0.0299054
RPS4X ribosomal protein S4, X-linked -0.0295242
MT2A metallothionein 2A -0.0290802
RPS14 ribosomal protein S14 -0.0287726
RBM39 RNA binding motif protein 39 -0.0287127
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0287116
CBX3 chromobox homolog 3 -0.0282419
EZR ezrin -0.0280655
DEK DEK proto-oncogene -0.0279751
FOXO1 forkhead box O1 -0.0278728
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.027869
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0275087
TSPAN8 tetraspanin 8 -0.0274619
ARF4 ADP-ribosylation factor 4 -0.0273075
RPS20 ribosomal protein S20 -0.0269741
PERP PERP, TP53 apoptosis effector -0.026893
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0268736
PPARG peroxisome proliferator-activated receptor gamma -0.0268313
TPM4 tropomyosin 4 -0.0267875
EIF1 eukaryotic translation initiation factor 1 -0.0265016
NRN1 neuritin 1 -0.0264735
SRP54 signal recognition particle 54kDa -0.0261493
FTL ferritin, light polypeptide -0.0260897
MKI67 marker of proliferation Ki-67 -0.0258521
CTNND1 catenin (cadherin-associated protein), delta 1 -0.025801
CLDN4 claudin 4 -0.0254049
SRSF11 serine/arginine-rich splicing factor 11 -0.0250829
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0250777
CALU calumenin -0.0248854
KPNB1 karyopherin (importin) beta 1 -0.0247404
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0247191
TOP1 topoisomerase (DNA) I -0.0246291
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0242939
SCAF11 SR-related CTD-associated factor 11 -0.0242415
MATR3 matrin 3 -0.0240923
ATF4 activating transcription factor 4 -0.0240803
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0239432
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0234109
RPL19 ribosomal protein L19 -0.0234052
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0233995
SEC31A SEC31 homolog A (S. cerevisiae) -0.0233705
IER3 immediate early response 3 -0.0229984
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0229831
MON2 MON2 homolog (S. cerevisiae) -0.0229751
RPL27A ribosomal protein L27a -0.0229522
AKAP9 A kinase (PRKA) anchor protein 9 -0.0227228
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.0224832
VDAC1 voltage-dependent anion channel 1 -0.0221756
KTN1 kinectin 1 (kinesin receptor) -0.0219423
RAB1A RAB1A, member RAS oncogene family -0.0219323
CLINT1 clathrin interactor 1 -0.0218438
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.021838
EIF5B eukaryotic translation initiation factor 5B -0.0218013
BIRC6 baculoviral IAP repeat containing 6 -0.0217816
CCNI cyclin I -0.021687
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0214491