| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.226207 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.21731 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.130341 |
| TXNRD1 | thioredoxin reductase 1 | 0.103638 |
| MT2A | metallothionein 2A | 0.0943038 |
| FMNL2 | formin-like 2 | 0.0848033 |
| CAPRIN2 | caprin family member 2 | 0.0818707 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0814862 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0778824 |
| KLF6 | Kruppel-like factor 6 | 0.077532 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0696244 |
| EZR | ezrin | 0.0690009 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0684266 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.067439 |
| HMGA1 | high mobility group AT-hook 1 | 0.0662675 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0617416 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.060777 |
| SPAG9 | sperm associated antigen 9 | 0.0592868 |
| DST | dystonin | 0.0582785 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0557647 |
| LDHA | lactate dehydrogenase A | 0.0545569 |
| EREG | epiregulin | 0.05439 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0540878 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0523726 |
| MT1X | metallothionein 1X | 0.0484499 |
| RUNX1 | runt-related transcription factor 1 | 0.0478684 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0463134 |
| MT1E | metallothionein 1E | 0.0455237 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0450283 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0441135 |
| SQSTM1 | sequestosome 1 | 0.0440312 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0440225 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0437967 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0435216 |
| JMJD1C | jumonji domain containing 1C | 0.0429151 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0421055 |
| ARRDC3 | arrestin domain containing 3 | 0.0420449 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0416202 |
| ANGPTL4 | angiopoietin-like 4 | 0.0416062 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0415916 |
| UBC | ubiquitin C | 0.0405779 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0387156 |
| RPL26 | ribosomal protein L26 | 0.0381474 |
| EMP1 | epithelial membrane protein 1 | 0.0374903 |
| PYGL | phosphorylase, glycogen, liver | 0.0374158 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0365771 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0364782 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0350208 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.034823 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0345818 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0339382 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0339305 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0337862 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0334463 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0321671 |
| RPS12 | ribosomal protein S12 | 0.0320336 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0319975 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0311722 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0311605 |
| ADAR | adenosine deaminase, RNA-specific | 0.0309345 |
| ENO1 | enolase 1, (alpha) | 0.0306023 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.030557 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0286705 |
| RAI1 | retinoic acid induced 1 | 0.0283487 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0283129 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0282567 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0282318 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.0279976 |
| AHNAK | AHNAK nucleoprotein | 0.0279523 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0276589 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0272162 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0270318 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0269758 |
| ANXA1 | annexin A1 | 0.0261067 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0260863 |
| DENND5A | DENN/MADD domain containing 5A | 0.0256257 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0255483 |
| SEC24A | SEC24 family member A | 0.0248654 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0243616 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0240925 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0240007 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0238062 |
| TXNIP | thioredoxin interacting protein | 0.0235943 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0235366 |
| PGK1 | phosphoglycerate kinase 1 | 0.023249 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0232026 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0230716 |
| HOMER1 | homer scaffolding protein 1 | 0.0230298 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0229506 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0229477 |
| JUN | jun proto-oncogene | 0.0227121 |
| RPS2 | ribosomal protein S2 | 0.0221465 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0219873 |
| SYAP1 | synapse associated protein 1 | 0.0218231 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0217792 |
| TFRC | transferrin receptor | 0.0217516 |
| RGS4 | regulator of G-protein signaling 4 | 0.0217344 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0216739 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0216672 |
| EGR1 | early growth response 1 | 0.0213579 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.192342 |
| TMSB10 | thymosin beta 10 | -0.0994936 |
| FTL | ferritin, light polypeptide | -0.092945 |
| VIM | vimentin | -0.0665628 |
| RPL31 | ribosomal protein L31 | -0.0573476 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0565356 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0561134 |
| CADM2 | cell adhesion molecule 2 | -0.0561123 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0519342 |
| RPS19 | ribosomal protein S19 | -0.0511256 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0507982 |
| TNS3 | tensin 3 | -0.04967 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0482616 |
| RPS6 | ribosomal protein S6 | -0.0473759 |
| EHBP1 | EH domain binding protein 1 | -0.0448305 |
| RPLP1 | ribosomal protein, large, P1 | -0.0425708 |
| EFNA5 | ephrin-A5 | -0.0421524 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0400819 |
| TP63 | tumor protein p63 | -0.0363189 |
| RPL35A | ribosomal protein L35a | -0.036216 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0356892 |
| CFAP299 | cilia and flagella associated protein 299 | -0.035668 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0356094 |
| EGFR | epidermal growth factor receptor | -0.0347843 |
| EPHA4 | EPH receptor A4 | -0.0343793 |
| ANKRD12 | ankyrin repeat domain 12 | -0.032383 |
| RPL37A | ribosomal protein L37a | -0.0323219 |
| WASF2 | WAS protein family, member 2 | -0.0305007 |
| COL5A2 | collagen, type V, alpha 2 | -0.0291118 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0287176 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0283468 |
| RPS24 | ribosomal protein S24 | -0.0281517 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.0278692 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0265642 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.026192 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0257499 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0257071 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0255312 |
| RPS23 | ribosomal protein S23 | -0.0248691 |
| RSF1 | remodeling and spacing factor 1 | -0.0246554 |
| HLA-A | major histocompatibility complex, class I, A | -0.0245776 |
| RAD51B | RAD51 paralog B | -0.0240154 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0238038 |
| RPS14 | ribosomal protein S14 | -0.0232813 |
| RPLP2 | ribosomal protein, large, P2 | -0.0231009 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.022961 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0229516 |
| DPH6 | diphthamine biosynthesis 6 | -0.022314 |
| PTK2 | protein tyrosine kinase 2 | -0.0222255 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0221713 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0220123 |
| CCDC91 | coiled-coil domain containing 91 | -0.0219491 |
| RIGI | RNA sensor RIG-I | -0.0218498 |
| THOC2 | THO complex 2 | -0.0216909 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0211124 |
| SP100 | SP100 nuclear antigen | -0.0209161 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0208757 |
| TBCA | tubulin folding cofactor A | -0.0205464 |
| CALD1 | caldesmon 1 | -0.0203387 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0202894 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0202516 |
| RPS17 | ribosomal protein S17 | -0.0201861 |
| RBM25 | RNA binding motif protein 25 | -0.0201554 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0201292 |
| ZNF609 | zinc finger protein 609 | -0.0199196 |
| RPS29 | ribosomal protein S29 | -0.0198189 |
| RPL28 | ribosomal protein L28 | -0.0196917 |
| AEBP2 | AE binding protein 2 | -0.0195881 |
| CUX1 | cut-like homeobox 1 | -0.0191594 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0190237 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0189928 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0188343 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0183729 |
| RPS20 | ribosomal protein S20 | -0.018344 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0182698 |
| TPRG1 | tumor protein p63 regulated 1 | -0.0181061 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.01809 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0179649 |
| SETD5 | SET domain containing 5 | -0.0178613 |
| ZMIZ2 | zinc finger, MIZ-type containing 2 | -0.0178339 |
| S100A9 | S100 calcium binding protein A9 | -0.0178279 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0177774 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0175094 |
| RPL36 | ribosomal protein L36 | -0.0173627 |
| CENPF | centromere protein F, 350/400kDa | -0.0173379 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0170224 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0169359 |
| MAP4 | microtubule-associated protein 4 | -0.016868 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0165072 |
| FOXN3 | forkhead box N3 | -0.0165067 |
| RPS5 | ribosomal protein S5 | -0.0164685 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0163326 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0162416 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.016192 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0161055 |
| RPL19 | ribosomal protein L19 | -0.0159294 |
| RPS13 | ribosomal protein S13 | -0.0159041 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0158808 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.0153563 |
| EXOC4 | exocyst complex component 4 | -0.0153324 |
