| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.357767 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.345604 |
| INTS6 | integrator complex subunit 6 | 0.0841208 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0674617 |
| MCL1 | myeloid cell leukemia 1 | 0.0673569 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.059235 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0586762 |
| SLTM | SAFB-like, transcription modulator | 0.0543165 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.054254 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.053164 |
| EGR1 | early growth response 1 | 0.0497678 |
| EFNA5 | ephrin-A5 | 0.0489853 |
| RPS3 | ribosomal protein S3 | 0.0485466 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0447402 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0446123 |
| SMAD3 | SMAD family member 3 | 0.0445157 |
| RNF213 | ring finger protein 213 | 0.0437661 |
| RPS12 | ribosomal protein S12 | 0.0433909 |
| MYO1E | myosin IE | 0.0425183 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0423931 |
| RAD51B | RAD51 paralog B | 0.0413323 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0410706 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0402571 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0396786 |
| HOMER1 | homer scaffolding protein 1 | 0.0396723 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0389272 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0376343 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0368787 |
| RPL37A | ribosomal protein L37a | 0.03648 |
| AREG | amphiregulin | 0.0348345 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0342217 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0317046 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0303778 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0300285 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0297789 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0293151 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0292238 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0286592 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0286065 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0285688 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0284299 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0277923 |
| B2M | beta-2-microglobulin | 0.0270289 |
| ARRDC3 | arrestin domain containing 3 | 0.0265968 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0265913 |
| RPL35A | ribosomal protein L35a | 0.0263972 |
| ENO1 | enolase 1, (alpha) | 0.0260176 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0257738 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0257133 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0256113 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0249859 |
| BMP6 | bone morphogenetic protein 6 | 0.0248876 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.024697 |
| SP100 | SP100 nuclear antigen | 0.0242708 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.024161 |
| RPS8 | ribosomal protein S8 | 0.0237836 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0231599 |
| RPS25 | ribosomal protein S25 | 0.0230733 |
| SIK3 | SIK family kinase 3 | 0.0227755 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0226648 |
| RPS29 | ribosomal protein S29 | 0.0225855 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0225065 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0219128 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0213166 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0209869 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0209666 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0209281 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0208493 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0207767 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0205707 |
| RPL11 | ribosomal protein L11 | 0.0205126 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0205009 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0203957 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0201176 |
| RPS27A | ribosomal protein S27a | 0.0201086 |
| RPS17 | ribosomal protein S17 | 0.0200404 |
| GPHN | gephyrin | 0.0200208 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0197909 |
| SVIL | supervillin | 0.0194712 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.019423 |
| VMP1 | vacuole membrane protein 1 | 0.0193863 |
| S100P | S100 calcium binding protein P | 0.0193355 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0192864 |
| CPE | carboxypeptidase E | 0.0191627 |
| HLA-B | major histocompatibility complex, class I, B | 0.0190209 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0188498 |
| FOXP1 | forkhead box P1 | 0.0188162 |
| MX1 | MX dynamin-like GTPase 1 | 0.0187908 |
| CTBP2 | C-terminal binding protein 2 | 0.0186236 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0184788 |
| RPS13 | ribosomal protein S13 | 0.0180525 |
| CMIP | c-Maf inducing protein | 0.0179054 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0176015 |
| STC1 | stanniocalcin 1 | 0.0174751 |
| IFI44 | interferon-induced protein 44 | 0.0172036 |
| TMEM45B | transmembrane protein 45B | 0.0171392 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0168937 |
| NABP1 | nucleic acid binding protein 1 | 0.0168601 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0167719 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0167362 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.220395 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0731618 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0572527 |
| OSMR | oncostatin M receptor | -0.0520336 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0516716 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0511664 |
| TES | testin LIM domain protein | -0.0498173 |
| H1-0 | H1.0 linker histone | -0.049442 |
| TMEM165 | transmembrane protein 165 | -0.0463904 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0463122 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0459577 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0459011 |
| LAMC2 | laminin, gamma 2 | -0.0457218 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.04474 |
| HDLBP | high density lipoprotein binding protein | -0.0438771 |
| TOP1 | topoisomerase (DNA) I | -0.0429121 |
| MKI67 | marker of proliferation Ki-67 | -0.0380286 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0377881 |
| NGLY1 | N-glycanase 1 | -0.0373715 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0372843 |
| RBM39 | RNA binding motif protein 39 | -0.0372814 |
| PGK1 | phosphoglycerate kinase 1 | -0.0362359 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.035817 |
| LMO7 | LIM domain 7 | -0.0357061 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0350416 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.03476 |
| OGA | O-GlcNAcase | -0.033253 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0328044 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0326661 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0323632 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0323028 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0312903 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0308543 |
| LAMA4 | laminin, alpha 4 | -0.030731 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0304931 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0304617 |
| SEPTIN2 | septin 2 | -0.0291092 |
| ASPH | aspartate beta-hydroxylase | -0.0286302 |
| FTL | ferritin, light polypeptide | -0.0285212 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0278913 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0278891 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0278415 |
| PTMA | prothymosin, alpha | -0.0276124 |
| CANX | calnexin | -0.0274658 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0271906 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0269003 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0268647 |
| PKM | pyruvate kinase, muscle | -0.0263349 |
| WASF2 | WAS protein family, member 2 | -0.0260836 |
| ABLIM1 | actin binding LIM protein 1 | -0.0257593 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0252053 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0249663 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0246594 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0245757 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0245389 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0243689 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0238654 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0238354 |
| RBM25 | RNA binding motif protein 25 | -0.0237774 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0236694 |
| SEC24D | SEC24 family member D | -0.0233596 |
| RTN4 | reticulon 4 | -0.0229544 |
| SUCO | SUN domain containing ossification factor | -0.0227156 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0225842 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0225305 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0224966 |
| GM2A | GM2 ganglioside activator | -0.0218012 |
| MATR3 | matrin 3 | -0.0216883 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0211372 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.021079 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0209231 |
| CLTC | clathrin, heavy chain (Hc) | -0.020719 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0207062 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0207003 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0205652 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0203383 |
| WDR45B | WD repeat domain 45B | -0.0202523 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0201607 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0200684 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0200588 |
| TKT | transketolase | -0.0199582 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0199484 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0199167 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0196727 |
| UBE4A | ubiquitination factor E4A | -0.01965 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0195993 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0194117 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0193272 |
| RAD21 | RAD21 homolog (S. pombe) | -0.019276 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0192068 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0191757 |
| TLK1 | tousled-like kinase 1 | -0.019121 |
| RAB10 | RAB10, member RAS oncogene family | -0.0189668 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0187895 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0185494 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0181961 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0181755 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0180754 |
| CDCP1 | CUB domain containing protein 1 | -0.0179281 |
| RC3H1 | ring finger and CCCH-type domains 1 | -0.0179106 |
