| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.102066 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0688214 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0631022 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0622076 |
| PCBP2 | poly(rC) binding protein 2 | 0.059615 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0520161 |
| NAV2 | neuron navigator 2 | 0.0502236 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0481644 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0451692 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0433414 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0432256 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0417731 |
| CD44 | CD44 molecule (Indian blood group) | 0.0414815 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0408461 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0383625 |
| TGM2 | transglutaminase 2 | 0.0380696 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0373674 |
| LOXL2 | lysyl oxidase-like 2 | 0.0347044 |
| HMGA1 | high mobility group AT-hook 1 | 0.0341586 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0338163 |
| NDRG1 | N-myc downstream regulated 1 | 0.0333251 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0331621 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0314379 |
| VEGFA | vascular endothelial growth factor A | 0.0311199 |
| ANKRD28 | ankyrin repeat domain 28 | 0.029163 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0284858 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0269092 |
| ECE1 | endothelin converting enzyme 1 | 0.0258271 |
| ANGPTL4 | angiopoietin-like 4 | 0.025681 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0253045 |
| IFI44L | interferon-induced protein 44-like | 0.0242688 |
| LDHA | lactate dehydrogenase A | 0.0242048 |
| CA12 | carbonic anhydrase XII | 0.0240598 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.023802 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0227079 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0225245 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0224683 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0224376 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0223993 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0218944 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0213683 |
| FAM20C | family with sequence similarity 20, member C | 0.021327 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0213199 |
| MYO10 | myosin X | 0.021177 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0210808 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0209235 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0207276 |
| SEPTIN9 | septin 9 | 0.0201939 |
| TGFB1 | transforming growth factor, beta 1 | 0.0197817 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0197149 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0193031 |
| NTN4 | netrin 4 | 0.0191836 |
| FLNB | filamin B, beta | 0.018828 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0186373 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0184253 |
| MT2A | metallothionein 2A | 0.0183766 |
| MX2 | MX dynamin-like GTPase 2 | 0.0182921 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0180047 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0174137 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0171332 |
| CFB | complement factor B | 0.0171316 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0171159 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0170444 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0169115 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0167425 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0163278 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0162965 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0161434 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0159826 |
| GANAB | glucosidase, alpha; neutral AB | 0.015955 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0158699 |
| PLEC | plectin | 0.0158682 |
| ARRDC3 | arrestin domain containing 3 | 0.0158455 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0157561 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0156426 |
| B2M | beta-2-microglobulin | 0.0155546 |
| FAM219A | family with sequence similarity 219, member A | 0.0155512 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0155158 |
| WWOX | WW domain containing oxidoreductase | 0.015485 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0153411 |
| INTS6 | integrator complex subunit 6 | 0.0152901 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0151059 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0150702 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0148319 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0144103 |
| MX1 | MX dynamin-like GTPase 1 | 0.0141766 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0141415 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0141234 |
| RHCG | Rh family, C glycoprotein | 0.0141189 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0140886 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0140722 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.013903 |
| RARB | retinoic acid receptor, beta | 0.0138802 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0137116 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0136442 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0135711 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0134955 |
| FOSL1 | FOS-like antigen 1 | 0.0134668 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0132123 |
| GPR176 | G protein-coupled receptor 176 | 0.0131007 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.156832 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.153137 |
| TMSB10 | thymosin beta 10 | -0.147688 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.127739 |
| VIM | vimentin | -0.126768 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.116076 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.102277 |
| GOLGA4 | golgin A4 | -0.1007 |
| RBM39 | RNA binding motif protein 39 | -0.094291 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0918354 |
| PTMA | prothymosin, alpha | -0.09161 |
| FN1 | fibronectin 1 | -0.0903957 |
| USP34 | ubiquitin specific peptidase 34 | -0.0756684 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0739979 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0711755 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0674748 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0660759 |
| STC1 | stanniocalcin 1 | -0.0631471 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0617307 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.060661 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0603924 |
| OSMR | oncostatin M receptor | -0.0588802 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0564247 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0556878 |
| HMGA2 | high mobility group AT-hook 2 | -0.0550574 |
| CDH13 | cadherin 13 | -0.0540256 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0540009 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0530206 |
| GLCCI1 | glucocorticoid induced 1 | -0.0518932 |
| MEF2A | myocyte enhancer factor 2A | -0.0517166 |
| HDLBP | high density lipoprotein binding protein | -0.0516611 |
| RPLP1 | ribosomal protein, large, P1 | -0.0510564 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.050687 |
| JMJD1C | jumonji domain containing 1C | -0.0504901 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0504229 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0499429 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0488304 |
| CANX | calnexin | -0.0484709 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0482472 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0473364 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.047032 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0465525 |
| SETD5 | SET domain containing 5 | -0.0456501 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0454716 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0453483 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0451213 |
| NF1 | neurofibromin 1 | -0.0451122 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0446915 |
| S100A6 | S100 calcium binding protein A6 | -0.0444472 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0441644 |
| FTL | ferritin, light polypeptide | -0.043228 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0431586 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0424866 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0418544 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0415584 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0414825 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0413936 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.040517 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0403369 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0403322 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0397265 |
| OXSR1 | oxidative stress responsive 1 | -0.0395323 |
| IER3 | immediate early response 3 | -0.0395091 |
| GNAS | GNAS complex locus | -0.0382632 |
| OXR1 | oxidation resistance 1 | -0.0381867 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0381465 |
| RIOK3 | RIO kinase 3 | -0.0378347 |
| TMSB4X | thymosin beta 4, X-linked | -0.0377921 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0374321 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0370279 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0367884 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0364275 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0363993 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0359413 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0357601 |
| RPS24 | ribosomal protein S24 | -0.0350681 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.034838 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0341091 |
| HM13 | histocompatibility (minor) 13 | -0.0332488 |
| PGK1 | phosphoglycerate kinase 1 | -0.0329552 |
| VMP1 | vacuole membrane protein 1 | -0.0329548 |
| OGA | O-GlcNAcase | -0.0326483 |
| TMEM165 | transmembrane protein 165 | -0.0321651 |
| MTSS1 | metastasis suppressor 1 | -0.0321292 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0319573 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0316628 |
| CFDP1 | craniofacial development protein 1 | -0.0316167 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0316048 |
| MECOM | MDS1 and EVI1 complex locus | -0.0313827 |
| ZNF804A | zinc finger protein 804A | -0.0313709 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0311118 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0308483 |
| TMEM263 | transmembrane protein 263 | -0.0307855 |
| DENND4A | DENN/MADD domain containing 4A | -0.0306059 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0303007 |
| VCL | vinculin | -0.0300845 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0298279 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0298196 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0298059 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0297343 |
