| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.229029 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.115709 |
| MCL1 | myeloid cell leukemia 1 | 0.0774094 |
| STC1 | stanniocalcin 1 | 0.0737077 |
| RPS12 | ribosomal protein S12 | 0.0728957 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0727483 |
| RPL37A | ribosomal protein L37a | 0.0682181 |
| IGF2 | insulin-like growth factor 2 | 0.0649102 |
| GRAMD1B | GRAM domain containing 1B | 0.0613713 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0597082 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0568014 |
| RPS3 | ribosomal protein S3 | 0.0504219 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0494211 |
| RPL26 | ribosomal protein L26 | 0.0491655 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0463853 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0449577 |
| HLA-B | major histocompatibility complex, class I, B | 0.0442814 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0435305 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0416315 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0414621 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0410227 |
| FDPS | farnesyl diphosphate synthase | 0.0379469 |
| EGR1 | early growth response 1 | 0.0361152 |
| RPS8 | ribosomal protein S8 | 0.03535 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0334738 |
| FLNB | filamin B, beta | 0.0331307 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0326475 |
| HLA-A | major histocompatibility complex, class I, A | 0.0323942 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0320512 |
| MT1X | metallothionein 1X | 0.0317706 |
| RPS29 | ribosomal protein S29 | 0.0309984 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0291345 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0270847 |
| RPS2 | ribosomal protein S2 | 0.0269404 |
| MUSK | muscle, skeletal, receptor tyrosine kinase | 0.0258953 |
| RPS27A | ribosomal protein S27a | 0.0257352 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0249173 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0245466 |
| ATP11A | ATPase, class VI, type 11A | 0.0244804 |
| RPL13A | ribosomal protein L13a | 0.0239864 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0239827 |
| PFN1 | profilin 1 | 0.0234067 |
| RAB7A | RAB7A, member RAS oncogene family | 0.021912 |
| RPL6 | ribosomal protein L6 | 0.0216606 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0213884 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0212179 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0212162 |
| NCKAP1 | NCK-associated protein 1 | 0.0208345 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0207718 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0206255 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0198388 |
| RPL35A | ribosomal protein L35a | 0.0196839 |
| CTSL | cathepsin L | 0.0196713 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.0191586 |
| CMIP | c-Maf inducing protein | 0.0190758 |
| RPS23 | ribosomal protein S23 | 0.0187969 |
| ANGPTL4 | angiopoietin-like 4 | 0.0187517 |
| FMNL2 | formin-like 2 | 0.0187472 |
| ITGB5 | integrin, beta 5 | 0.0186351 |
| NABP1 | nucleic acid binding protein 1 | 0.0181228 |
| LAMA5 | laminin, alpha 5 | 0.0180863 |
| TPM3 | tropomyosin 3 | 0.0175241 |
| RPS27 | ribosomal protein S27 | 0.0173853 |
| RPS15A | ribosomal protein S15a | 0.0173594 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0172561 |
| RPS10 | ribosomal protein S10 | 0.0172381 |
| NRG1 | neuregulin 1 | 0.0171862 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0169197 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0167873 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0167195 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.016698 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0166307 |
| FADS2 | fatty acid desaturase 2 | 0.0158512 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0158278 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.0155697 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0155367 |
| RPS13 | ribosomal protein S13 | 0.0154356 |
| MSN | moesin | 0.0153025 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0152984 |
| RPS25 | ribosomal protein S25 | 0.0150719 |
| RPS11 | ribosomal protein S11 | 0.0149545 |
| RPL37 | ribosomal protein L37 | 0.0147432 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0146396 |
| RPL36 | ribosomal protein L36 | 0.0143537 |
| RPL23 | ribosomal protein L23 | 0.0142996 |
| RPL3 | ribosomal protein L3 | 0.0141599 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0141274 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0140707 |
| BRD2 | bromodomain containing 2 | 0.013724 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0137153 |
| RCOR1 | REST corepressor 1 | 0.0136461 |
| GLIS3 | GLIS family zinc finger 3 | 0.0135459 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0133983 |
| HLA-E | major histocompatibility complex, class I, E | 0.0130927 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 0.0130826 |
| RPL15 | ribosomal protein L15 | 0.0130395 |
| CDCP1 | CUB domain containing protein 1 | 0.0128922 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0128801 |
| LPIN1 | lipin 1 | 0.0127208 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0126579 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.260106 |
| TMSB10 | thymosin beta 10 | -0.20186 |
| VIM | vimentin | -0.175086 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.169902 |
| PTMA | prothymosin, alpha | -0.142223 |
| RPLP1 | ribosomal protein, large, P1 | -0.118195 |
| TXNRD1 | thioredoxin reductase 1 | -0.1013 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0945766 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0875948 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0790572 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0676741 |
| IER3 | immediate early response 3 | -0.0669124 |
| FGB | fibrinogen beta chain | -0.0627966 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0626528 |
| CAVIN1 | caveolae associated protein 1 | -0.0541739 |
| RPL19 | ribosomal protein L19 | -0.053734 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0510641 |
| S100A6 | S100 calcium binding protein A6 | -0.0509335 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0496718 |
| AHNAK | AHNAK nucleoprotein | -0.0486077 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0460614 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0440839 |
| ANXA2 | annexin A2 | -0.0434901 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0424641 |
| DST | dystonin | -0.0417334 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0415625 |
| MYOF | myoferlin | -0.0413595 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0400495 |
| SEPTIN7 | septin 7 | -0.0400143 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0395824 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0384464 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0378424 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0377209 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0376192 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0375261 |
| PKM | pyruvate kinase, muscle | -0.0371401 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0363953 |
| FGG | fibrinogen gamma chain | -0.0359354 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0356384 |
| LMNA | lamin A/C | -0.0354362 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0354208 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0352862 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0344398 |
| WWOX | WW domain containing oxidoreductase | -0.0344179 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0335245 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0334207 |
| CANX | calnexin | -0.0330771 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0329751 |
| RPS6 | ribosomal protein S6 | -0.0328235 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.032367 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0322564 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0322438 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0320425 |
| RPLP0 | ribosomal protein, large, P0 | -0.0319245 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.031563 |
| TAGLN2 | transgelin 2 | -0.0312998 |
| DEK | DEK proto-oncogene | -0.0312951 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0306795 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0301877 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.030111 |
| CENPF | centromere protein F, 350/400kDa | -0.0294082 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0293627 |
| RPS5 | ribosomal protein S5 | -0.0291622 |
| LDHA | lactate dehydrogenase A | -0.0288423 |
| RPL32 | ribosomal protein L32 | -0.0286794 |
| YBX3 | Y box binding protein 3 | -0.02815 |
| ENO1 | enolase 1, (alpha) | -0.0279964 |
| BICC1 | BicC family RNA binding protein 1 | -0.0277771 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0273228 |
| RPL4 | ribosomal protein L4 | -0.0272985 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0272053 |
| HMGB1 | high mobility group box 1 | -0.027142 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0266826 |
| RPL34 | ribosomal protein L34 | -0.0263406 |
| AHR | aryl hydrocarbon receptor | -0.0262586 |
| VCL | vinculin | -0.0261322 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0260408 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0259252 |
| TNPO1 | transportin 1 | -0.025581 |
| TPM4 | tropomyosin 4 | -0.0252248 |
| RPL36AL | ribosomal protein L36a-like | -0.0251662 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0240349 |
| TPX2 | TPX2, microtubule-associated | -0.0239773 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0239204 |
| RASAL2 | RAS protein activator like 2 | -0.0238702 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0236509 |
| B2M | beta-2-microglobulin | -0.0233756 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0232705 |
| MAP4 | microtubule-associated protein 4 | -0.0232171 |
| SEPTIN2 | septin 2 | -0.0231913 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0231158 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.022793 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0224694 |
| RAB10 | RAB10, member RAS oncogene family | -0.0224523 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0223689 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0223509 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0222661 |
| RPS19 | ribosomal protein S19 | -0.0222075 |
| RTN4 | reticulon 4 | -0.0220784 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0219602 |
