| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.305153 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.112955 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0981892 |
| LAMC2 | laminin, gamma 2 | 0.0729252 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0713095 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0678059 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0650707 |
| TJP1 | tight junction protein 1 | 0.0650161 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0641922 |
| SMAD3 | SMAD family member 3 | 0.0624664 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0611477 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0609943 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0589829 |
| EGFR | epidermal growth factor receptor | 0.0589751 |
| MYO1E | myosin IE | 0.0580936 |
| HMGA2 | high mobility group AT-hook 2 | 0.058003 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0570426 |
| FRMD4A | FERM domain containing 4A | 0.0568511 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0563954 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.056115 |
| FBXO11 | F-box protein 11 | 0.0550371 |
| RPS8 | ribosomal protein S8 | 0.0542586 |
| CDH13 | cadherin 13 | 0.0525776 |
| RAD51B | RAD51 paralog B | 0.0524553 |
| SQSTM1 | sequestosome 1 | 0.052316 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0522531 |
| LAMB3 | laminin, beta 3 | 0.0519601 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0507155 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0506869 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0506341 |
| DST | dystonin | 0.0501029 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0493398 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0488187 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0482706 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0472151 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0458661 |
| AFDN | afadin, adherens junction formation factor | 0.0448995 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0448706 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0446846 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0441516 |
| CUL3 | cullin 3 | 0.0436868 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0435931 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0433096 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0429927 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0426352 |
| VCL | vinculin | 0.0423275 |
| DSPP | dentin sialophosphoprotein | 0.0423026 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0419754 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0410757 |
| CMIP | c-Maf inducing protein | 0.0410692 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0410097 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0409229 |
| ATXN1 | ataxin 1 | 0.0407756 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0399525 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0396953 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0391241 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.038088 |
| CUX1 | cut-like homeobox 1 | 0.0380436 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0379536 |
| RBM47 | RNA binding motif protein 47 | 0.037802 |
| FUS | FUS RNA binding protein | 0.0377131 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.037407 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0372813 |
| MCL1 | myeloid cell leukemia 1 | 0.0370729 |
| PCNX1 | pecanex 1 | 0.0366221 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.036475 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0360051 |
| ENO1 | enolase 1, (alpha) | 0.0358857 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0353887 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0351722 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0349372 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0339962 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0336895 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0336387 |
| APOB | apolipoprotein B | 0.0336365 |
| ACTN4 | actinin, alpha 4 | 0.0333314 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0332257 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0331057 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.03283 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0325582 |
| JAK1 | Janus kinase 1 | 0.0324042 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0320698 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.031859 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0317692 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0317219 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0316524 |
| ADAR | adenosine deaminase, RNA-specific | 0.0314051 |
| CD44 | CD44 molecule (Indian blood group) | 0.0312046 |
| SIK3 | SIK family kinase 3 | 0.0309304 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.030764 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0304961 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0304112 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0300294 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0298108 |
| CANX | calnexin | 0.0298006 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0295973 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0295432 |
| TAOK1 | TAO kinase 1 | 0.0294561 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0292668 |
| SYT1 | synaptotagmin I | 0.0292514 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.108621 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.102804 |
| GRB10 | growth factor receptor-bound protein 10 | -0.100592 |
| TMSB10 | thymosin beta 10 | -0.0760349 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0741683 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0731079 |
| NDRG1 | N-myc downstream regulated 1 | -0.0696548 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0677107 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0672828 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0667024 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0606869 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0596752 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0595511 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.059244 |
| KIAA1217 | KIAA1217 | -0.0585809 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.0584324 |
| RPS25 | ribosomal protein S25 | -0.0582447 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0555046 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0550452 |
| PDE10A | phosphodiesterase 10A | -0.0548554 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0543893 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.053614 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0532134 |
| SEC24D | SEC24 family member D | -0.0529244 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0519784 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0519324 |
| MYOF | myoferlin | -0.0516319 |
| ABHD17C | abhydrolase domain containing 17C | -0.0496979 |
| KIAA1671 | KIAA1671 | -0.0489959 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.048924 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0479124 |
| WDR45B | WD repeat domain 45B | -0.0468379 |
| S100A6 | S100 calcium binding protein A6 | -0.0467929 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0458775 |
| RPS19 | ribosomal protein S19 | -0.045559 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0448646 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0447349 |
| DSCAM | Down syndrome cell adhesion molecule | -0.044575 |
| RPS16 | ribosomal protein S16 | -0.0442706 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0440878 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0430108 |
| RIGI | RNA sensor RIG-I | -0.0428499 |
| PTMA | prothymosin, alpha | -0.0423875 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0423255 |
| COG6 | component of oligomeric golgi complex 6 | -0.0422677 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0422202 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0411038 |
| RPLP0 | ribosomal protein, large, P0 | -0.0409269 |
| ABLIM1 | actin binding LIM protein 1 | -0.0398555 |
| WASF2 | WAS protein family, member 2 | -0.0394193 |
| COPA | coatomer protein complex, subunit alpha | -0.0392346 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.038969 |
| RPL31 | ribosomal protein L31 | -0.0379363 |
| SETD5 | SET domain containing 5 | -0.0377624 |
| RPS12 | ribosomal protein S12 | -0.0377091 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0371498 |
| CALD1 | caldesmon 1 | -0.0368974 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0367759 |
| TANK | TRAF family member-associated NFKB activator | -0.0363859 |
| MYO5B | myosin VB | -0.0358143 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.0356339 |
| SRP54 | signal recognition particle 54kDa | -0.0353611 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0353306 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0352126 |
| PRELID2 | PRELI domain containing 2 | -0.0350752 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0347585 |
| ANXA2 | annexin A2 | -0.0345697 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0342399 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0340692 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0337973 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0336081 |
| DENND1A | DENN/MADD domain containing 1A | -0.0331043 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0329641 |
| RPL35A | ribosomal protein L35a | -0.0324365 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | -0.0321512 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0318638 |
| VIM | vimentin | -0.031596 |
| OXSR1 | oxidative stress responsive 1 | -0.0314671 |
| PKM | pyruvate kinase, muscle | -0.0314169 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0310342 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0309336 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0308327 |
| FOXO3 | forkhead box O3 | -0.0308248 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0307414 |
| NBEA | neurobeachin | -0.0304371 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0298305 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0297282 |
| FNBP4 | formin binding protein 4 | -0.0296633 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0294178 |
| FOXO1 | forkhead box O1 | -0.028882 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0287726 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0287213 |
| PEG10 | paternally expressed 10 | -0.0286909 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0286745 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0284331 |
| RRBP1 | ribosome binding protein 1 | -0.0282812 |
| TBCA | tubulin folding cofactor A | -0.0281595 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.027826 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0277651 |
| EHBP1 | EH domain binding protein 1 | -0.027551 |
