| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.119936 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.110223 |
| GRAMD1B | GRAM domain containing 1B | 0.0995302 |
| ATP11A | ATPase, class VI, type 11A | 0.0860224 |
| TPM3 | tropomyosin 3 | 0.0842821 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0780207 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.076929 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0738906 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0733024 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0709934 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0691552 |
| PRKCE | protein kinase C, epsilon | 0.067179 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0663188 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0642509 |
| YBX3 | Y box binding protein 3 | 0.0637448 |
| PCBP2 | poly(rC) binding protein 2 | 0.0633145 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0592748 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0584536 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0566455 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0527676 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0499874 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.049726 |
| MCL1 | myeloid cell leukemia 1 | 0.0450803 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0445156 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0417216 |
| FMNL2 | formin-like 2 | 0.0412103 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0401872 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0382822 |
| ADAR | adenosine deaminase, RNA-specific | 0.0375494 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0374351 |
| INTS6 | integrator complex subunit 6 | 0.0365359 |
| RPS12 | ribosomal protein S12 | 0.0364927 |
| SIK3 | SIK family kinase 3 | 0.0362547 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0354287 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0348748 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0340676 |
| RPS7 | ribosomal protein S7 | 0.0339295 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0339192 |
| CMIP | c-Maf inducing protein | 0.0337861 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0336524 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0336513 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.033401 |
| RPS3 | ribosomal protein S3 | 0.0331233 |
| PYGL | phosphorylase, glycogen, liver | 0.0330036 |
| RUNX1 | runt-related transcription factor 1 | 0.0328554 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0325567 |
| PDE10A | phosphodiesterase 10A | 0.0324252 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0323285 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0322997 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0322273 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0320416 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0319885 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0316631 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0315534 |
| TLN1 | talin 1 | 0.031468 |
| GPHN | gephyrin | 0.0310371 |
| DST | dystonin | 0.0309826 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.030708 |
| KLF6 | Kruppel-like factor 6 | 0.0300249 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0297312 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0293751 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0291406 |
| EXOC6B | exocyst complex component 6B | 0.0290911 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0290748 |
| EXOC4 | exocyst complex component 4 | 0.0288534 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0286692 |
| ANO6 | anoctamin 6 | 0.0286182 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0283299 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0281681 |
| CTTN | cortactin | 0.0280931 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0278276 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.026992 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0269493 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0269153 |
| RPL5 | ribosomal protein L5 | 0.0267177 |
| JMJD1C | jumonji domain containing 1C | 0.0262194 |
| PLEC | plectin | 0.0260581 |
| BRD2 | bromodomain containing 2 | 0.0260418 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0259815 |
| SMYD3 | SET and MYND domain containing 3 | 0.0252192 |
| WWOX | WW domain containing oxidoreductase | 0.0251524 |
| FLNA | filamin A, alpha | 0.0248483 |
| SMAD3 | SMAD family member 3 | 0.0245591 |
| R3HDM2 | R3H domain containing 2 | 0.0238941 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0238517 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0238057 |
| PRELID2 | PRELI domain containing 2 | 0.023585 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0235371 |
| RPL13A | ribosomal protein L13a | 0.023467 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0234489 |
| RPS2 | ribosomal protein S2 | 0.0234084 |
| RPL26 | ribosomal protein L26 | 0.0234046 |
| HOMER1 | homer scaffolding protein 1 | 0.0232738 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.023177 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.023131 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0231299 |
| ZNF638 | zinc finger protein 638 | 0.0229572 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0228822 |
| PTK2 | protein tyrosine kinase 2 | 0.0227768 |
| NCKAP1 | NCK-associated protein 1 | 0.0227722 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.148483 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.14601 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.137236 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.123822 |
| VIM | vimentin | -0.110018 |
| VCL | vinculin | -0.0626346 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0600017 |
| TMSB10 | thymosin beta 10 | -0.0524163 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.051668 |
| RSF1 | remodeling and spacing factor 1 | -0.0506107 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.049796 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0468156 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0424949 |
| GNAS | GNAS complex locus | -0.0403129 |
| H1-0 | H1.0 linker histone | -0.0396441 |
| KPNB1 | karyopherin (importin) beta 1 | -0.03879 |
| CD2AP | CD2-associated protein | -0.0386629 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0376003 |
| CENPF | centromere protein F, 350/400kDa | -0.0373352 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0361423 |
| WASF2 | WAS protein family, member 2 | -0.0359072 |
| RPS24 | ribosomal protein S24 | -0.0354339 |
| TPM4 | tropomyosin 4 | -0.0345277 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0344948 |
| BBX | bobby sox homolog (Drosophila) | -0.0342136 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0337004 |
| ZFR | zinc finger RNA binding protein | -0.0322712 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0316519 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0314953 |
| THOC2 | THO complex 2 | -0.0313831 |
| RBM25 | RNA binding motif protein 25 | -0.0307129 |
| CAVIN1 | caveolae associated protein 1 | -0.029995 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0294781 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0293966 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0291311 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0290724 |
| RPLP1 | ribosomal protein, large, P1 | -0.0285145 |
| SETX | senataxin | -0.028273 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0278472 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0278199 |
| RYR3 | ryanodine receptor 3 | -0.0276613 |
| TPX2 | TPX2, microtubule-associated | -0.0275834 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.027538 |
| MKI67 | marker of proliferation Ki-67 | -0.027127 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0268955 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.026812 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0261686 |
| TXNRD1 | thioredoxin reductase 1 | -0.026125 |
| TMEM165 | transmembrane protein 165 | -0.0257773 |
| TPI1 | triosephosphate isomerase 1 | -0.0256915 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0256519 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0253351 |
| OSMR | oncostatin M receptor | -0.0251042 |
| FMN1 | formin 1 | -0.0250862 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0249415 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0248128 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0248108 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0248073 |
| IMMT | inner membrane protein, mitochondrial | -0.0245849 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0245279 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0244231 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0244145 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0243828 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0241692 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0241419 |
| DEK | DEK proto-oncogene | -0.0241316 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0238898 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0237898 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.023767 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0232506 |
| SGO2 | shugoshin 2 | -0.0228918 |
| XPO1 | exportin 1 | -0.0228546 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0228378 |
| CENPE | centromere protein E, 312kDa | -0.0228364 |
| PHIP | pleckstrin homology domain interacting protein | -0.0227149 |
| RPL34 | ribosomal protein L34 | -0.0227119 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0225957 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0225409 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.022515 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0224131 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0223244 |
| EGR1 | early growth response 1 | -0.0222235 |
| CCNL1 | cyclin L1 | -0.022033 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0219616 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0218981 |
| S100A10 | S100 calcium binding protein A10 | -0.0218767 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0215294 |
| RAB10 | RAB10, member RAS oncogene family | -0.0215155 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0214956 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.021399 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0213915 |
| RBM39 | RNA binding motif protein 39 | -0.0211988 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | -0.0210091 |
| IER3 | immediate early response 3 | -0.0210084 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0209805 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.020931 |
| SRP72 | signal recognition particle 72kDa | -0.0209247 |
| UBB | ubiquitin B | -0.0209243 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0207779 |
| RAI1 | retinoic acid induced 1 | -0.0206756 |
