| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lapatinib ditosylate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.12598 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.104009 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.102725 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.101176 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0930823 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0852679 |
| RPS3 | ribosomal protein S3 | 0.0783617 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0761871 |
| SQSTM1 | sequestosome 1 | 0.0691366 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0639196 |
| RPL37A | ribosomal protein L37a | 0.0595569 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0592159 |
| ACTG1 | actin gamma 1 | 0.0588953 |
| RPS12 | ribosomal protein S12 | 0.056551 |
| NAV2 | neuron navigator 2 | 0.0548171 |
| INTS6 | integrator complex subunit 6 | 0.0524619 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0504225 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0503566 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.050171 |
| DTNA | dystrobrevin, alpha | 0.0475026 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0471262 |
| SMAD3 | SMAD family member 3 | 0.0470463 |
| MCL1 | myeloid cell leukemia 1 | 0.0468764 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0464347 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0459966 |
| RPS29 | ribosomal protein S29 | 0.0456249 |
| RPL9 | ribosomal protein L9 | 0.0454208 |
| PTK2 | protein tyrosine kinase 2 | 0.0445021 |
| LAMC2 | laminin, gamma 2 | 0.0444761 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0443973 |
| EGR1 | early growth response 1 | 0.0443301 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0441082 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.043303 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0427668 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0423485 |
| PLEC | plectin | 0.0422238 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0421453 |
| MXD1 | MAX dimerization protein 1 | 0.0412949 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0401523 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0400613 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0398789 |
| RYBP | RING1 and YY1 binding protein | 0.0398672 |
| FAM13A | family with sequence similarity 13, member A | 0.0360922 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0355571 |
| USP53 | ubiquitin specific peptidase 53 | 0.0348621 |
| RPS27A | ribosomal protein S27a | 0.0339092 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.033863 |
| CTBP2 | C-terminal binding protein 2 | 0.0332343 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0326927 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0322923 |
| RPS13 | ribosomal protein S13 | 0.0320685 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0320426 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0319535 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0313703 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0311112 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0305481 |
| RPS23 | ribosomal protein S23 | 0.0299692 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0299296 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0293243 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0290646 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0286661 |
| FHIT | fragile histidine triad | 0.028659 |
| TFRC | transferrin receptor | 0.0280362 |
| PRKCA | protein kinase C, alpha | 0.0278927 |
| RPL13A | ribosomal protein L13a | 0.0277893 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0276897 |
| FLNB | filamin B, beta | 0.0273962 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0271613 |
| SDC4 | syndecan 4 | 0.0270826 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0270815 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0269667 |
| MYO5B | myosin VB | 0.0267346 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0267334 |
| RPL7A | ribosomal protein L7a | 0.0265919 |
| BAIAP2 | BAI1-associated protein 2 | 0.0262076 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0261197 |
| EFNA5 | ephrin-A5 | 0.0258453 |
| APP | amyloid beta (A4) precursor protein | 0.0258373 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0257699 |
| RPS10 | ribosomal protein S10 | 0.0255049 |
| RPL5 | ribosomal protein L5 | 0.0254214 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0252838 |
| NABP1 | nucleic acid binding protein 1 | 0.0252773 |
| RPL6 | ribosomal protein L6 | 0.0251277 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0251234 |
| KIAA1217 | KIAA1217 | 0.0249548 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0246964 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.02463 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.024528 |
| RPL35A | ribosomal protein L35a | 0.0244909 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0242353 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.024188 |
| SERINC5 | serine incorporator 5 | 0.0236772 |
| UPP1 | uridine phosphorylase 1 | 0.0236747 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0234695 |
| RPS25 | ribosomal protein S25 | 0.0230743 |
| LGMN | legumain | 0.0230422 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0229123 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0228284 |
| BRD2 | bromodomain containing 2 | 0.0227713 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.177731 |
| FTL | ferritin, light polypeptide | -0.153079 |
| TMSB10 | thymosin beta 10 | -0.108609 |
| S100A6 | S100 calcium binding protein A6 | -0.0718358 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0692825 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.065968 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0624139 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.060008 |
| RPLP1 | ribosomal protein, large, P1 | -0.0592199 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0557722 |
| LMO7 | LIM domain 7 | -0.0531915 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0493313 |
| FBXO32 | F-box protein 32 | -0.0465811 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0452085 |
| TPM4 | tropomyosin 4 | -0.0440283 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0422469 |
| RNF145 | ring finger protein 145 | -0.0413412 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0410219 |
| RPS6 | ribosomal protein S6 | -0.0397755 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0375555 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0363647 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0363155 |
| TXNIP | thioredoxin interacting protein | -0.0358432 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0357699 |
| RBM25 | RNA binding motif protein 25 | -0.0354692 |
| TMEM123 | transmembrane protein 123 | -0.0341258 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0335876 |
| FAM3C | family with sequence similarity 3, member C | -0.0335411 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0335397 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0328051 |
| PKM | pyruvate kinase, muscle | -0.0327799 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0327307 |
| CD2AP | CD2-associated protein | -0.0326993 |
| DSG2 | desmoglein 2 | -0.0325531 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0324089 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0322054 |
| TOP1 | topoisomerase (DNA) I | -0.0310187 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0304412 |
| RPS19 | ribosomal protein S19 | -0.0300085 |
| CBX3 | chromobox homolog 3 | -0.0294483 |
| VIM | vimentin | -0.0292131 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0282354 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0282112 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0281674 |
| TFG | TRK-fused gene | -0.0281315 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0280138 |
| SEPTIN7 | septin 7 | -0.0277477 |
| RIOK3 | RIO kinase 3 | -0.0272432 |
| RPL32 | ribosomal protein L32 | -0.0270621 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0265492 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.026383 |
| RPL34 | ribosomal protein L34 | -0.0257488 |
| SNX6 | sorting nexin 6 | -0.0255012 |
| CENPF | centromere protein F, 350/400kDa | -0.0254219 |
| JMJD1C | jumonji domain containing 1C | -0.0250913 |
| GNAS | GNAS complex locus | -0.024907 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0246679 |
| TRAM1 | translocation associated membrane protein 1 | -0.0246464 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0245754 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0242459 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0238855 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0237414 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0235934 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.02311 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0230631 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0226816 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0226578 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0222446 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0220809 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0220194 |
| TPI1 | triosephosphate isomerase 1 | -0.0219553 |
| TES | testin LIM domain protein | -0.0218211 |
| AHNAK | AHNAK nucleoprotein | -0.021701 |
| SETD5 | SET domain containing 5 | -0.0212975 |
| GPX4 | glutathione peroxidase 4 | -0.0210175 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0210072 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0208162 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0207897 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | -0.0207789 |
| DSTN | destrin (actin depolymerizing factor) | -0.0205852 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0204468 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0203639 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0203266 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0203127 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0203023 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0202998 |
| CCNL1 | cyclin L1 | -0.0202115 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0202108 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0201962 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0198016 |
| RPL8 | ribosomal protein L8 | -0.0197177 |
| FAM162A | family with sequence similarity 162, member A | -0.0194572 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0194449 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0194229 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0193209 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0193107 |
| TMSB4X | thymosin beta 4, X-linked | -0.0192794 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0192678 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0186941 |
| TAGLN2 | transgelin 2 | -0.0186123 |
