Lapatinib ditosylate_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.204484
NAMPT nicotinamide phosphoribosyltransferase 0.114533
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0905417
TPT1 tumor protein, translationally-controlled 1 0.0880698
GRAMD1B GRAM domain containing 1B 0.0669999
EFNA5 ephrin-A5 0.0660937
RPL26 ribosomal protein L26 0.0655274
VIM vimentin 0.062123
LDHA lactate dehydrogenase A 0.0591784
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0591022
ESYT2 extended synaptotagmin-like protein 2 0.054855
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.054606
RPS12 ribosomal protein S12 0.0544728
GDA guanine deaminase 0.0543651
EEF2 eukaryotic translation elongation factor 2 0.0535021
TM4SF1 transmembrane 4 L six family member 1 0.0534782
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0533289
ELL2 elongation factor, RNA polymerase II, 2 0.0497877
EZR ezrin 0.0491569
RPS8 ribosomal protein S8 0.048887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0483223
MCL1 myeloid cell leukemia 1 0.0473453
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0470965
RPL37A ribosomal protein L37a 0.0469049
CXCL8 chemokine (C-X-C motif) ligand 8 0.046342
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0451393
HSPA8 heat shock 70kDa protein 8 0.0436062
RPL23 ribosomal protein L23 0.0428005
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0426025
FLNB filamin B, beta 0.0424211
PGK1 phosphoglycerate kinase 1 0.0422083
RPS3 ribosomal protein S3 0.0414886
ENO1 enolase 1, (alpha) 0.0406898
RPL12 ribosomal protein L12 0.0402298
NAP1L1 nucleosome assembly protein 1-like 1 0.0395652
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0390297
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0382166
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0381557
DGKD diacylglycerol kinase, delta 130kDa 0.0378577
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0376353
RPL36A ribosomal protein L36a 0.0370324
TRIO trio Rho guanine nucleotide exchange factor 0.0368629
RPS6 ribosomal protein S6 0.0364532
SQSTM1 sequestosome 1 0.0352127
SH3KBP1 SH3-domain kinase binding protein 1 0.035119
NDRG1 N-myc downstream regulated 1 0.034989
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0349748
EIF1 eukaryotic translation initiation factor 1 0.0346581
CANX calnexin 0.0345923
RPS27A ribosomal protein S27a 0.0341864
FTH1 ferritin, heavy polypeptide 1 0.0335843
UBC ubiquitin C 0.0334035
ERRFI1 ERBB receptor feedback inhibitor 1 0.0331692
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0329514
PYGL phosphorylase, glycogen, liver 0.032948
CD44 CD44 molecule (Indian blood group) 0.0328081
TGFBI transforming growth factor, beta-induced, 68kDa 0.0326502
RACK1 receptor for activated C kinase 1 0.0325943
RPL13A ribosomal protein L13a 0.0325674
ANXA2 annexin A2 0.0322081
RPLP0 ribosomal protein, large, P0 0.0322058
RPL19 ribosomal protein L19 0.0316799
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0315394
RPL35A ribosomal protein L35a 0.031184
SAMD4A sterile alpha motif domain containing 4A 0.0309385
RPL11 ribosomal protein L11 0.0300057
RAB3B RAB3B, member RAS oncogene family 0.0299257
KYNU kynureninase 0.0295537
ANXA1 annexin A1 0.0295211
S100A10 S100 calcium binding protein A10 0.0287312
B2M beta-2-microglobulin 0.0286385
RPS27 ribosomal protein S27 0.0285665
ASPH aspartate beta-hydroxylase 0.0279696
RPS2 ribosomal protein S2 0.0279639
DDIT4 DNA-damage-inducible transcript 4 0.0278295
RPS23 ribosomal protein S23 0.0277908
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0276837
RPL31 ribosomal protein L31 0.0273473
FMNL2 formin-like 2 0.0273058
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0272215
RPL7A ribosomal protein L7a 0.0271251
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0267196
FTL ferritin, light polypeptide 0.0260896
TXNRD1 thioredoxin reductase 1 0.0260174
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0260106
NCAM1 neural cell adhesion molecule 1 0.026003
PRRC2C proline-rich coiled-coil 2C 0.0258019
RPL5 ribosomal protein L5 0.0257399
RPL9 ribosomal protein L9 0.0256328
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0251818
MT2A metallothionein 2A 0.0251563
KRT19 keratin 19, type I 0.0251134
HLA-B major histocompatibility complex, class I, B 0.0249957
RPS25 ribosomal protein S25 0.0249323
NPAS2 neuronal PAS domain protein 2 0.0247148
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.024593
RPS13 ribosomal protein S13 0.0240634
TFPI2 tissue factor pathway inhibitor 2 0.0240018
EEF1G eukaryotic translation elongation factor 1 gamma 0.023891
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0237783

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.180791
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.137713
NALF1 NALCN channel auxiliary factor 1 -0.0747764
COL5A2 collagen, type V, alpha 2 -0.0693948
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0567408
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0524214
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0477541
LSAMP limbic system-associated membrane protein -0.0399254
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0397666
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0349754
VCL vinculin -0.0346998
SMYD3 SET and MYND domain containing 3 -0.0337248
PM20D1 peptidase M20 domain containing 1 -0.0283661
KIAA0825 KIAA0825 -0.0280234
NCKAP5 NCK-associated protein 5 -0.0275222
PBX1 pre-B-cell leukemia homeobox 1 -0.0263859
P3H2 prolyl 3-hydroxylase 2 -0.0263042
PCDH15 protocadherin-related 15 -0.0235342
DST dystonin -0.0230341
TTC28 tetratricopeptide repeat domain 28 -0.0230244
RTN1 reticulon 1 -0.0223921
FNDC3B fibronectin type III domain containing 3B -0.0217895
TENM3 teneurin transmembrane protein 3 -0.0214552
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0213393
WARS1 tryptophanyl-tRNA synthetase 1 -0.0206712
BCAS3 breast carcinoma amplified sequence 3 -0.0196843
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0194883
PRKD3 protein kinase D3 -0.0189904
SOX6 SRY (sex determining region Y)-box 6 -0.0178157
CADM2 cell adhesion molecule 2 -0.017499
ADGRB3 adhesion G protein-coupled receptor B3 -0.0162224
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.016183
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0160082
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0155343
CDH13 cadherin 13 -0.0148511
RAD51B RAD51 paralog B -0.0146778
AEBP2 AE binding protein 2 -0.0144023
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0143975
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0143901
NCAM2 neural cell adhesion molecule 2 -0.014362
PDE1A phosphodiesterase 1A, calmodulin-dependent -0.0138561
PTPRD protein tyrosine phosphatase, receptor type, D -0.0138268
PTEN phosphatase and tensin homolog -0.0136981
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -0.0136178
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0132293
RIGI RNA sensor RIG-I -0.0129353
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0129003
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0121952
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0120459
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0119724
PDE7B phosphodiesterase 7B -0.0118446
NCOA7 nuclear receptor coactivator 7 -0.0116804
ZBTB20 zinc finger and BTB domain containing 20 -0.0115317
THSD4 thrombospondin, type I, domain containing 4 -0.0115156
EPHA5 EPH receptor A5 -0.0114107
NRCAM neuronal cell adhesion molecule -0.010853
TPM4 tropomyosin 4 -0.010755
ATAD1 ATPase family, AAA domain containing 1 -0.0107381
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0107293
STAG2 stromal antigen 2 -0.0107148
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0106839
LAMA5 laminin, alpha 5 -0.0105039
PCBP3 poly(rC) binding protein 3 -0.0104804
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0103809
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -0.010153
STEAP1B STEAP family member 1B -0.0100755
PDLIM5 PDZ and LIM domain 5 -0.0100341
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0100193
GLCCI1 glucocorticoid induced 1 -0.009962
DNAH14 dynein, axonemal, heavy chain 14 -0.00988876
CPED1 cadherin-like and PC-esterase domain containing 1 -0.00984698
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00969156
HMGA2 high mobility group AT-hook 2 -0.00937934
THSD7A thrombospondin, type I, domain containing 7A -0.00934079
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00930321
DNAH11 dynein, axonemal, heavy chain 11 -0.00929275
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.00911989
PAPPA2 pappalysin 2 -0.00905803
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.00885086
ZFC3H1 zinc finger, C3H1-type containing -0.00883221
TAS2R14 taste receptor, type 2, member 14 -0.00859056
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.00854479
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.00852261
ZNF644 zinc finger protein 644 -0.0084867
FSTL4 follistatin-like 4 -0.00837183
PNISR PNN-interacting serine/arginine-rich protein -0.00827414
LAMB1 laminin, beta 1 -0.00825581
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00825444
DHFR dihydrofolate reductase -0.00819043
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0081066
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.00809983
PCDH9 protocadherin 9 -0.00803661
MAML2 mastermind-like 2 (Drosophila) -0.00789869
MYPN myopalladin -0.0078443
NOTCH3 notch 3 -0.00778947
PRSS23 protease, serine, 23 -0.00772813
IFI44 interferon-induced protein 44 -0.00754948
SORBS2 sorbin and SH3 domain containing 2 -0.00746671
CEMIP cell migration inducing protein, hyaluronan binding -0.00733433
TENM1 teneurin transmembrane protein 1 -0.00731834