| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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173 genes differentially expressed following the Lapatinib ditosylate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.215978 |
| NDRG1 | N-myc downstream regulated 1 | 0.21114 |
| RUNX1 | runt-related transcription factor 1 | 0.17983 |
| EFNA5 | ephrin-A5 | 0.16889 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.123955 |
| DTNA | dystrobrevin, alpha | 0.121407 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.118652 |
| EXT1 | exostosin glycosyltransferase 1 | 0.117858 |
| MMP12 | matrix metallopeptidase 12 | 0.116585 |
| RPS12 | ribosomal protein S12 | 0.115514 |
| EGFR | epidermal growth factor receptor | 0.112165 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.111104 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0916436 |
| LDHA | lactate dehydrogenase A | 0.0909701 |
| SPAG9 | sperm associated antigen 9 | 0.0898875 |
| CD109 | CD109 molecule | 0.0892754 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0838362 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0799257 |
| EZR | ezrin | 0.0779964 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.074305 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0740771 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0719631 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0718638 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0711587 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.07005 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0667115 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0665395 |
| SMAD3 | SMAD family member 3 | 0.062036 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0617044 |
| RPL35A | ribosomal protein L35a | 0.0613383 |
| GPHN | gephyrin | 0.0607707 |
| APP | amyloid beta (A4) precursor protein | 0.056597 |
| PTK2 | protein tyrosine kinase 2 | 0.0565477 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0552217 |
| RPL26 | ribosomal protein L26 | 0.0550609 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0527058 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0514044 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0512736 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0502764 |
| RPS23 | ribosomal protein S23 | 0.0502454 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0498618 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.048771 |
| RPS19 | ribosomal protein S19 | 0.0482914 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0482463 |
| PGK1 | phosphoglycerate kinase 1 | 0.047861 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0452999 |
| RPL37A | ribosomal protein L37a | 0.0443177 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0442527 |
| RAD51B | RAD51 paralog B | 0.0432771 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0431635 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0416917 |
| DST | dystonin | 0.0411223 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0394325 |
| ZNF292 | zinc finger protein 292 | 0.0379306 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0378937 |
| VIM | vimentin | 0.0357594 |
| ASPH | aspartate beta-hydroxylase | 0.0353589 |
| RPS8 | ribosomal protein S8 | 0.0349447 |
| DSCAM | Down syndrome cell adhesion molecule | 0.032838 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0320875 |
| PARD3 | par-3 family cell polarity regulator | 0.0307842 |
| RPL34 | ribosomal protein L34 | 0.0300158 |
| ATP13A3 | ATPase type 13A3 | 0.0288658 |
| HLA-B | major histocompatibility complex, class I, B | 0.0276563 |
| CANX | calnexin | 0.0262573 |
| HDAC9 | histone deacetylase 9 | 0.025932 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0253915 |
| RPL11 | ribosomal protein L11 | 0.0250436 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0245466 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0208075 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0193226 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0183992 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.017144 |
| ANXA2 | annexin A2 | 0.0171061 |
| RPS6 | ribosomal protein S6 | 0.0168908 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0161037 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0153765 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0152116 |
| STC1 | stanniocalcin 1 | 0.0138845 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0124695 |
| MT2A | metallothionein 2A | 0.00893197 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.00849945 |
| MYO10 | myosin X | 0.0072914 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.00649604 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0060295 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.00504965 |
| NCKAP5 | NCK-associated protein 5 | 0.00458415 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.00264777 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.00163961 |
| MCL1 | myeloid cell leukemia 1 | 1.17216E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.201718 |
| TMSB10 | thymosin beta 10 | -0.162906 |
| PTMA | prothymosin, alpha | -0.149965 |
| FN1 | fibronectin 1 | -0.139057 |
| OSMR | oncostatin M receptor | -0.136565 |
| PKM | pyruvate kinase, muscle | -0.126541 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0982932 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0948894 |
| PDE10A | phosphodiesterase 10A | -0.0945168 |
| GOLGA4 | golgin A4 | -0.087837 |
| NF1 | neurofibromin 1 | -0.0873693 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0824826 |
| NAV1 | neuron navigator 1 | -0.0818937 |
| SMYD3 | SET and MYND domain containing 3 | -0.0816966 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.076201 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0753951 |
| TJP1 | tight junction protein 1 | -0.0741384 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0696341 |
| FLNB | filamin B, beta | -0.0649442 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0643202 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0627403 |
| ITGA6 | integrin, alpha 6 | -0.0620848 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0612002 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0599207 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0544637 |
| S100A9 | S100 calcium binding protein A9 | -0.0533123 |
| SLTM | SAFB-like, transcription modulator | -0.0526242 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0521102 |
| MAP4 | microtubule-associated protein 4 | -0.052068 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0515997 |
| AHNAK | AHNAK nucleoprotein | -0.0505501 |
| ENO1 | enolase 1, (alpha) | -0.0503533 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0501981 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0489215 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0488269 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.047544 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0473384 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0473287 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0472641 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0467828 |
| PRELID2 | PRELI domain containing 2 | -0.0463047 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0449003 |
| UBC | ubiquitin C | -0.0446673 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0444664 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.043586 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0435036 |
| B2M | beta-2-microglobulin | -0.0426656 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0420181 |
| RPLP1 | ribosomal protein, large, P1 | -0.0406252 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0396095 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0374048 |
| CCNI | cyclin I | -0.0362178 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0353589 |
| MYO1E | myosin IE | -0.0324845 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0322998 |
| COL5A2 | collagen, type V, alpha 2 | -0.0313013 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.030366 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.030042 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0273816 |
| TXNRD1 | thioredoxin reductase 1 | -0.0263289 |
| MCU | mitochondrial calcium uniporter | -0.0250981 |
| VCL | vinculin | -0.0241746 |
| LOXL2 | lysyl oxidase-like 2 | -0.0235407 |
| SETD5 | SET domain containing 5 | -0.0233903 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0222304 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0196184 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0191118 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0169159 |
| AFDN | afadin, adherens junction formation factor | -0.0153797 |
| PRKCA | protein kinase C, alpha | -0.0152151 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.013487 |
| LMO7 | LIM domain 7 | -0.0121211 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0103861 |
| INTS6 | integrator complex subunit 6 | -0.00903556 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.00880289 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.00842116 |
| JMJD1C | jumonji domain containing 1C | -0.00832625 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.00816866 |
| FNDC3A | fibronectin type III domain containing 3A | -0.00802219 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.00711518 |
| MYOF | myoferlin | -0.002188 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.00214135 |
| HMGA2 | high mobility group AT-hook 2 | -2.18697E-4 |
