Lapatinib ditosylate_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Lapatinib ditosylate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.105323
RPS12 ribosomal protein S12 0.0870806
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0798916
RPL35A ribosomal protein L35a 0.0723535
PHIP pleckstrin homology domain interacting protein 0.0717542
PARD3B par-3 family cell polarity regulator beta 0.0679954
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0641873
WSB1 WD repeat and SOCS box containing 1 0.061623
RPS8 ribosomal protein S8 0.0597218
LRRC4C leucine rich repeat containing 4C 0.0593017
PRTG protogenin 0.0566483
RPS3 ribosomal protein S3 0.0548092
BPTF bromodomain PHD finger transcription factor 0.0538616
RPL37A ribosomal protein L37a 0.050907
ATXN2 ataxin 2 0.0508188
EEF1G eukaryotic translation elongation factor 1 gamma 0.0493653
RPS16 ribosomal protein S16 0.0493074
TPT1 tumor protein, translationally-controlled 1 0.0479449
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0474042
ISG15 ISG15 ubiquitin-like modifier 0.0464467
NCAM2 neural cell adhesion molecule 2 0.044921
CAMTA1 calmodulin binding transcription activator 1 0.0447373
RPL37 ribosomal protein L37 0.0436328
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0430686
SBF2 SET binding factor 2 0.0405936
RACK1 receptor for activated C kinase 1 0.0398777
RPS25 ribosomal protein S25 0.0398757
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0396303
RPS6 ribosomal protein S6 0.0393315
SREBF2 sterol regulatory element binding transcription factor 2 0.0390054
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0389292
APLP2 amyloid beta (A4) precursor-like protein 2 0.0366487
MCL1 myeloid cell leukemia 1 0.0365216
B2M beta-2-microglobulin 0.0362475
COL1A2 collagen, type I, alpha 2 0.0360439
NEBL nebulette 0.0355911
NCOR2 nuclear receptor corepressor 2 0.0354625
MRPS6 mitochondrial ribosomal protein S6 0.0354333
RPL26 ribosomal protein L26 0.0354292
MDK midkine (neurite growth-promoting factor 2) 0.0352259
GSE1 Gse1 coiled-coil protein 0.0350118
WWOX WW domain containing oxidoreductase 0.0348673
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0348531
BMPR1A bone morphogenetic protein receptor, type IA 0.0348359
RPL23 ribosomal protein L23 0.0348127
TMSB10 thymosin beta 10 0.0344269
FTL ferritin, light polypeptide 0.0342823
RPS23 ribosomal protein S23 0.0338655
CHD1 chromodomain helicase DNA binding protein 1 0.0336331
CDH10 cadherin 10, type 2 (T2-cadherin) 0.033509
RPS13 ribosomal protein S13 0.0334804
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0333822
ITGAV integrin, alpha V 0.0329579
ARID1A AT rich interactive domain 1A (SWI-like) 0.0329277
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0327901
SQSTM1 sequestosome 1 0.0317926
GARRE1 granule associated Rac and RHOG effector 1 0.0317405
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0313888
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0312478
SOS1 son of sevenless homolog 1 (Drosophila) 0.0307874
DSCAM Down syndrome cell adhesion molecule 0.0305133
PGAP1 post-GPI attachment to proteins 1 0.0300524
RPL13A ribosomal protein L13a 0.0298612
AKAP13 A kinase (PRKA) anchor protein 13 0.0298169
PRKD1 protein kinase D1 0.0297975
ANKRD33B ankyrin repeat domain 33B 0.0295515
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0294094
TTC28 tetratricopeptide repeat domain 28 0.0294047
RPL15 ribosomal protein L15 0.0288975
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0288231
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0287369
KMT2C lysine (K)-specific methyltransferase 2C 0.0285341
RPL36A ribosomal protein L36a 0.0282115
ARL15 ADP-ribosylation factor-like 15 0.0277311
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0275124
RPS17 ribosomal protein S17 0.0273806
MBD5 methyl-CpG binding domain protein 5 0.0273459
SERF2 small EDRK-rich factor 2 0.0270931
TRAK1 trafficking protein, kinesin binding 1 0.0268386
RPS29 ribosomal protein S29 0.0267802
EP300 E1A binding protein p300 0.0267609
NIPBL Nipped-B homolog (Drosophila) 0.0267376
CCNY cyclin Y 0.0265848
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0264798
RPL9 ribosomal protein L9 0.0263418
RPL11 ribosomal protein L11 0.0262161
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0258416
BRD2 bromodomain containing 2 0.0253786
RPL5 ribosomal protein L5 0.0253565
RPL28 ribosomal protein L28 0.025075
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0250503
TRERF1 transcriptional regulating factor 1 0.0248845
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0248666
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0248364
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0247336
RPL31 ribosomal protein L31 0.024706
DENND4A DENN/MADD domain containing 4A 0.0246442
NHSL1 NHS-like 1 0.0246402
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0245178
BRD4 bromodomain containing 4 0.0245005

decreased expression

Symbol Name Standardized Value
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.145588
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.121366
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.102623
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0975884
TMSB4X thymosin beta 4, X-linked -0.0914992
GPC3 glypican 3 -0.0858729
THBS1 thrombospondin 1 -0.0794845
PEG10 paternally expressed 10 -0.0690995
HMGB2 high mobility group box 2 -0.061601
MKI67 marker of proliferation Ki-67 -0.0592186
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0559478
ACTG1 actin gamma 1 -0.0544822
EMP1 epithelial membrane protein 1 -0.0538672
CADM2 cell adhesion molecule 2 -0.051905
DST dystonin -0.0513233
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0503551
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0496618
AHNAK AHNAK nucleoprotein -0.0488887
NRG1 neuregulin 1 -0.048258
MATR3 matrin 3 -0.0467679
NPAS3 neuronal PAS domain protein 3 -0.0466228
POTEF POTE ankyrin domain family, member F -0.0455698
CENPF centromere protein F, 350/400kDa -0.0449657
ZNF385D zinc finger protein 385D -0.0443898
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0443896
ZNF292 zinc finger protein 292 -0.0443736
SLC38A2 solute carrier family 38, member 2 -0.0430068
FAM171B family with sequence similarity 171, member B -0.0425656
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0418806
HMGB1 high mobility group box 1 -0.0412026
SFRP4 secreted frizzled-related protein 4 -0.0405388
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0400896
TPX2 TPX2, microtubule-associated -0.0388393
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0387675
VIM vimentin -0.0385205
ANXA2 annexin A2 -0.0383823
SRP72 signal recognition particle 72kDa -0.0380044
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.037904
PDE4D phosphodiesterase 4D, cAMP-specific -0.037668
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0371487
CDK6 cyclin-dependent kinase 6 -0.0370291
ZFR zinc finger RNA binding protein -0.0368483
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0367096
ADGRL2 adhesion G protein-coupled receptor L2 -0.0366964
KIF5B kinesin family member 5B -0.036295
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0360047
MAP4 microtubule-associated protein 4 -0.0359167
SPAG9 sperm associated antigen 9 -0.0352772
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0349026
OLA1 Obg-like ATPase 1 -0.0347983
MTF2 metal response element binding transcription factor 2 -0.0346928
CBX3 chromobox homolog 3 -0.0340283
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.033946
SORBS2 sorbin and SH3 domain containing 2 -0.0339237
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0334362
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0321344
BTBD3 BTB (POZ) domain containing 3 -0.0321054
SERINC1 serine incorporator 1 -0.0318201
ACTN4 actinin, alpha 4 -0.0317837
PRPF8 pre-mRNA processing factor 8 -0.0317286
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0316051
PDGFC platelet derived growth factor C -0.0315528
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0315353
HELZ helicase with zinc finger -0.0314469
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0314017
TXNRD1 thioredoxin reductase 1 -0.0311989
RBM39 RNA binding motif protein 39 -0.0311852
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0311846
YBX1 Y box binding protein 1 -0.0310972
SEPTIN7 septin 7 -0.0308305
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E -0.0304687
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0301184
LMAN1 lectin, mannose-binding, 1 -0.0299712
CAVIN1 caveolae associated protein 1 -0.0298287
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0296949
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0295834
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0294886
STAG2 stromal antigen 2 -0.0292778
MYL12B myosin, light chain 12B, regulatory -0.0287126
DEK DEK proto-oncogene -0.0286365
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0284924
TMEM64 transmembrane protein 64 -0.0283539
PALLD palladin, cytoskeletal associated protein -0.0280007
FBL fibrillarin -0.0279647
GLO1 glyoxalase I -0.0276806
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0276702
VGLL3 vestigial-like family member 3 -0.0272718
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0268743
HMCN1 hemicentin 1 -0.0268347
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0266689
ECT2 epithelial cell transforming 2 -0.0266659
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0265402
SHROOM3 shroom family member 3 -0.0262377
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0261746
EVI5 ecotropic viral integration site 5 -0.0259503
AK1 adenylate kinase 1 -0.0257641
CKAP5 cytoskeleton associated protein 5 -0.0256882
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0255102
COL11A1 collagen, type XI, alpha 1 -0.0251613
RPLP1 ribosomal protein, large, P1 -0.025032