Lapatinib ditosylate_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in PANC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Lapatinib ditosylate_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 0.21252
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.175254
SEPTIN9 septin 9 0.0915012
RPS12 ribosomal protein S12 0.0871762
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0827705
SMAD3 SMAD family member 3 0.0792558
RPS3 ribosomal protein S3 0.0769353
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.065719
RPS27A ribosomal protein S27a 0.0616703
RPL37A ribosomal protein L37a 0.0609122
FNDC3B fibronectin type III domain containing 3B 0.0598495
UBC ubiquitin C 0.0559492
NAV2 neuron navigator 2 0.0544695
CTBP2 C-terminal binding protein 2 0.0521918
RPLP2 ribosomal protein, large, P2 0.0488597
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0453035
RPL35A ribosomal protein L35a 0.0451291
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0443801
PTK2 protein tyrosine kinase 2 0.043985
ZCCHC7 zinc finger, CCHC domain containing 7 0.0434894
INTS6 integrator complex subunit 6 0.0406193
MT2A metallothionein 2A 0.0384367
FLNB filamin B, beta 0.0381955
RPS25 ribosomal protein S25 0.0375397
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0369739
TPT1 tumor protein, translationally-controlled 1 0.0367921
PRELID2 PRELI domain containing 2 0.0362711
RPL26 ribosomal protein L26 0.0360953
RPS8 ribosomal protein S8 0.034296
PCBP2 poly(rC) binding protein 2 0.0340904
RPS17 ribosomal protein S17 0.0338491
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0331617
ZSWIM6 zinc finger, SWIM-type containing 6 0.0327938
ATXN1 ataxin 1 0.032786
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0327496
RPS13 ribosomal protein S13 0.0326165
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0323086
SAMD4B sterile alpha motif domain containing 4B 0.0321414
ZNF292 zinc finger protein 292 0.0321329
ANKRD11 ankyrin repeat domain 11 0.0315473
MYH9 myosin, heavy chain 9, non-muscle 0.0312951
ENO1 enolase 1, (alpha) 0.0308655
APLP2 amyloid beta (A4) precursor-like protein 2 0.0305013
MCL1 myeloid cell leukemia 1 0.0301371
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0293116
FBL fibrillarin 0.0290407
DDIT4 DNA-damage-inducible transcript 4 0.0288696
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0287
BRD2 bromodomain containing 2 0.0286761
RPL11 ribosomal protein L11 0.0284819
ARRDC3 arrestin domain containing 3 0.0276593
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0273462
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0271452
NCOR2 nuclear receptor corepressor 2 0.0269457
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.026899
HMGA1 high mobility group AT-hook 1 0.0268544
HPCAL1 hippocalcin-like 1 0.0262547
HSPA8 heat shock 70kDa protein 8 0.0252821
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0252614
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0252055
TRIO trio Rho guanine nucleotide exchange factor 0.025029
CDK19 cyclin-dependent kinase 19 0.0250243
CARS1 cysteinyl-tRNA synthetase 1 0.0247953
FMNL2 formin-like 2 0.02457
RPL36A ribosomal protein L36a 0.0243833
RPL37 ribosomal protein L37 0.0236439
RPL9 ribosomal protein L9 0.0233874
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0232833
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0231677
RPS2 ribosomal protein S2 0.0229673
RPS29 ribosomal protein S29 0.0229066
STC2 stanniocalcin 2 0.0228929
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0227287
RPS23 ribosomal protein S23 0.0226699
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0225215
ADM adrenomedullin 0.0224385
AFAP1 actin filament associated protein 1 0.0223782
APP amyloid beta (A4) precursor protein 0.0223189
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.022255
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0222197
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0221414
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0220541
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0220273
RPL28 ribosomal protein L28 0.0216878
SDK1 sidekick cell adhesion molecule 1 0.0216547
HDAC4 histone deacetylase 4 0.0212392
RPS10 ribosomal protein S10 0.0211472
NUP98 nucleoporin 98kDa 0.0210483
CA8 carbonic anhydrase VIII 0.0209162
RPL38 ribosomal protein L38 0.0208081
ANGPTL4 angiopoietin-like 4 0.0206943
KDM2A lysine (K)-specific demethylase 2A 0.0204338
ASPH aspartate beta-hydroxylase 0.0202455
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.020171
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0199865
RUNX1 runt-related transcription factor 1 0.0199462
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0197528
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0197518
CMIP c-Maf inducing protein 0.0194649
PLEC plectin 0.0193161

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.115973
AKAP12 A kinase (PRKA) anchor protein 12 -0.0925734
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0754744
CD44 CD44 molecule (Indian blood group) -0.0727404
PTMA prothymosin, alpha -0.0561244
VIM vimentin -0.0533312
RAP1B RAP1B, member of RAS oncogene family -0.042002
EXT1 exostosin glycosyltransferase 1 -0.0380349
TMEM123 transmembrane protein 123 -0.0318988
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0305475
RTN4 reticulon 4 -0.0276013
BMAL2 basic helix-loop-helix ARNT like 2 -0.0275797
TM4SF1 transmembrane 4 L six family member 1 -0.0262837
MAP1B microtubule-associated protein 1B -0.0261944
RASAL2 RAS protein activator like 2 -0.0260658
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0254609
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0251525
PRSS23 protease, serine, 23 -0.0250585
NCEH1 neutral cholesterol ester hydrolase 1 -0.0248701
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0241459
KLF6 Kruppel-like factor 6 -0.0240225
TMEM41B transmembrane protein 41B -0.0230878
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0230834
ADGRG6 adhesion G protein-coupled receptor G6 -0.0226815
TMSB10 thymosin beta 10 -0.0222084
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0219608
CARD18 caspase recruitment domain family, member 18 -0.0216586
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0206945
BIRC3 baculoviral IAP repeat containing 3 -0.0205905
RHOBTB3 Rho-related BTB domain containing 3 -0.0204294
OSMR oncostatin M receptor -0.0202483
ARHGAP29 Rho GTPase activating protein 29 -0.0201158
CBX3 chromobox homolog 3 -0.020115
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.020105
WWTR1 WW domain containing transcription regulator 1 -0.0200961
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0198902
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0196009
KPNB1 karyopherin (importin) beta 1 -0.0191604
JMJD1C jumonji domain containing 1C -0.0189767
HMGB1 high mobility group box 1 -0.0183345
H1-0 H1.0 linker histone -0.018181
EHBP1 EH domain binding protein 1 -0.0180695
CENPF centromere protein F, 350/400kDa -0.0180276
IQGAP1 IQ motif containing GTPase activating protein 1 -0.017987
FRMD5 FERM domain containing 5 -0.0179719
ELL2 elongation factor, RNA polymerase II, 2 -0.0175572
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0169258
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0163006
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0161392
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.016026
FHL2 four and a half LIM domains 2 -0.0158018
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0152545
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.0149636
TPM1 tropomyosin 1 (alpha) -0.0144485
ITPRID2 ITPR interacting domain containing 2 -0.0143247
REEP3 receptor accessory protein 3 -0.0142054
ABLIM1 actin binding LIM protein 1 -0.014186
ITGAV integrin, alpha V -0.0141615
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0141158
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0140147
RIN2 Ras and Rab interactor 2 -0.0138221
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0135001
UBASH3B ubiquitin associated and SH3 domain containing B -0.0134685
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0134123
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0132437
TPX2 TPX2, microtubule-associated -0.0131977
IL13RA1 interleukin 13 receptor, alpha 1 -0.0131838
BZW1 basic leucine zipper and W2 domains 1 -0.0131786
ODF2L outer dense fiber of sperm tails 2-like -0.013022
ACTN4 actinin, alpha 4 -0.012929
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0129029
SEPTIN7 septin 7 -0.0127933
ZNF644 zinc finger protein 644 -0.012655
CAV1 caveolin 1, caveolae protein, 22kDa -0.0126216
MSRB3 methionine sulfoxide reductase B3 -0.0126145
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.012584
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0123311
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0123098
LOC102724023 ES1 protein homolog, mitochondrial -0.0120848
NT5E 5'-nucleotidase, ecto (CD73) -0.0120803
HMGA2 high mobility group AT-hook 2 -0.012007
AHNAK AHNAK nucleoprotein -0.011978
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0119749
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0119721
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0119561
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0119382
RAD21 RAD21 homolog (S. pombe) -0.0118321
RAB31 RAB31, member RAS oncogene family -0.0117489
PERP PERP, TP53 apoptosis effector -0.0117144
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0117008
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.0116949
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0115711
GARS1 glycyl-tRNA synthetase 1 -0.0114792
GOSR1 golgi SNAP receptor complex member 1 -0.0114144
RPS4X ribosomal protein S4, X-linked -0.0113591
RESF1 retroelement silencing factor 1 -0.0112553
CAVIN1 caveolae associated protein 1 -0.0112474
RRBP1 ribosome binding protein 1 -0.011229
IPO7 importin 7 -0.0111322
BCAR3 breast cancer anti-estrogen resistance 3 -0.0110496