Lapatinib ditosylate_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.111737
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0979368
PABPC1 poly(A) binding protein, cytoplasmic 1 0.08869
SQSTM1 sequestosome 1 0.0811286
ARRDC3 arrestin domain containing 3 0.0725362
NAV2 neuron navigator 2 0.0619646
TPT1 tumor protein, translationally-controlled 1 0.0597202
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0580323
NDRG1 N-myc downstream regulated 1 0.057119
FAM107B family with sequence similarity 107, member B 0.0506399
LDHA lactate dehydrogenase A 0.0488396
FAM3C family with sequence similarity 3, member C 0.0446415
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0397288
MYO6 myosin VI 0.038702
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0384283
ATF3 activating transcription factor 3 0.038394
DSCAM Down syndrome cell adhesion molecule 0.0383589
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0378682
IRS2 insulin receptor substrate 2 0.037682
FMNL2 formin-like 2 0.0375084
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0374421
EEF2 eukaryotic translation elongation factor 2 0.0369591
LAMB3 laminin, beta 3 0.03597
TSC22D2 TSC22 domain family, member 2 0.035911
OGA O-GlcNAcase 0.0358785
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0357109
RYBP RING1 and YY1 binding protein 0.0346022
EIF4A2 eukaryotic translation initiation factor 4A2 0.0332127
TRIO trio Rho guanine nucleotide exchange factor 0.032995
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0317361
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0315398
KDM3A lysine (K)-specific demethylase 3A 0.0314243
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0296815
KRT17 keratin 17, type I 0.0294305
IFRD1 interferon-related developmental regulator 1 0.0291695
BHLHE40 basic helix-loop-helix family, member e40 0.0289459
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0288658
HSPA8 heat shock 70kDa protein 8 0.0282956
TACSTD2 tumor-associated calcium signal transducer 2 0.0282725
CD47 CD47 molecule 0.0280533
SHB Src homology 2 domain containing adaptor protein B 0.0280513
ARHGAP26 Rho GTPase activating protein 26 0.028006
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0279436
UBE2H ubiquitin-conjugating enzyme E2H 0.0277868
ANKRD33B ankyrin repeat domain 33B 0.027736
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.027684
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0274598
NAMPT nicotinamide phosphoribosyltransferase 0.0273931
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0271484
NCEH1 neutral cholesterol ester hydrolase 1 0.0270319
ZNF292 zinc finger protein 292 0.0269726
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0269709
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0267441
BRD2 bromodomain containing 2 0.0257981
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0257383
NCKAP1 NCK-associated protein 1 0.0256452
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0256398
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0254037
HLA-B major histocompatibility complex, class I, B 0.025386
BACE2 beta-site APP-cleaving enzyme 2 0.0252858
EEF1G eukaryotic translation elongation factor 1 gamma 0.0250612
KLF6 Kruppel-like factor 6 0.0249626
KLHL24 kelch-like family member 24 0.0245876
TFRC transferrin receptor 0.0244911
RLF rearranged L-myc fusion 0.0240567
CANX calnexin 0.0239493
NIPBL Nipped-B homolog (Drosophila) 0.0238376
MYO5B myosin VB 0.0235456
APP amyloid beta (A4) precursor protein 0.0234429
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0230354
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0229286
AFDN afadin, adherens junction formation factor 0.0228503
SIK3 SIK family kinase 3 0.0228304
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.022795
DDIT4 DNA-damage-inducible transcript 4 0.0224883
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0223355
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0222456
UBXN7 UBX domain protein 7 0.022017
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.021988
LRRC23 leucine rich repeat containing 23 0.0218027
CEMIP2 cell migration inducing hyaluronidase 2 0.0215448
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0212611
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0208556
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0208336
FOXO1 forkhead box O1 0.0206928
H2AC6 H2A clustered histone 6 0.0205568
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0202927
EIF1 eukaryotic translation initiation factor 1 0.0202771
GPHN gephyrin 0.020203
MYH9 myosin, heavy chain 9, non-muscle 0.0201518
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0201266
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.019782
RPL13A ribosomal protein L13a 0.019688
EMP1 epithelial membrane protein 1 0.0196516
SPAG9 sperm associated antigen 9 0.0195707
UST uronyl-2-sulfotransferase 0.0195241
CFB complement factor B 0.0195017
G0S2 G0/G1 switch 2 0.0193728
RPS3 ribosomal protein S3 0.0191131
PCLO piccolo presynaptic cytomatrix protein 0.0190468

decreased expression

Symbol Name Standardized Value
LAMA4 laminin, alpha 4 -0.114689
LMO7 LIM domain 7 -0.105286
F3 coagulation factor III (thromboplastin, tissue factor) -0.0931984
PTMA prothymosin, alpha -0.0906818
FN1 fibronectin 1 -0.0856063
TMSB10 thymosin beta 10 -0.0715184
IGFBP3 insulin-like growth factor binding protein 3 -0.0650554
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0638435
MAML2 mastermind-like 2 (Drosophila) -0.06328
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0612681
ASPH aspartate beta-hydroxylase -0.0581912
TPM4 tropomyosin 4 -0.057584
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0563907
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0562814
ZBTB20 zinc finger and BTB domain containing 20 -0.0540613
RPS6 ribosomal protein S6 -0.0515337
IFI27 interferon, alpha-inducible protein 27 -0.0475425
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0475236
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0474207
C6ORF132 chromosome 6 open reading frame 132 -0.0441666
EHBP1 EH domain binding protein 1 -0.0430704
CD44 CD44 molecule (Indian blood group) -0.0417948
DLG1 discs, large homolog 1 (Drosophila) -0.0417719
SYT14 synaptotagmin XIV -0.0400156
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0394088
DSG2 desmoglein 2 -0.03894
HMGA2 high mobility group AT-hook 2 -0.0387747
MUC4 mucin 4, cell surface associated -0.0386533
LY6E lymphocyte antigen 6 complex, locus E -0.0375332
KRT19 keratin 19, type I -0.0374302
CD2AP CD2-associated protein -0.036448
SACK1A scaffolding CK1 anchoring protein A -0.0359888
OSMR oncostatin M receptor -0.0359352
RAD51B RAD51 paralog B -0.0356657
ITGA6 integrin, alpha 6 -0.0352365
SULF2 sulfatase 2 -0.0349549
RNF213 ring finger protein 213 -0.0348294
TMSB4X thymosin beta 4, X-linked -0.0327943
MX2 MX dynamin-like GTPase 2 -0.0323651
VCL vinculin -0.0319187
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0318763
RIGI RNA sensor RIG-I -0.0317418
RPS19 ribosomal protein S19 -0.0315899
FTL ferritin, light polypeptide -0.0309658
WFDC2 WAP four-disulfide core domain 2 -0.0307212
RRBP1 ribosome binding protein 1 -0.0306419
RCOR1 REST corepressor 1 -0.0300785
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0296199
STAT1 signal transducer and activator of transcription 1, 91kDa -0.029329
SOX4 SRY (sex determining region Y)-box 4 -0.0285573
PLAT plasminogen activator, tissue -0.0282907
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0277612
SH3KBP1 SH3-domain kinase binding protein 1 -0.0275501
PLAUR plasminogen activator, urokinase receptor -0.027457
DAPK1 death-associated protein kinase 1 -0.0273032
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0271052
POTEF POTE ankyrin domain family, member F -0.0268138
MUC16 mucin 16, cell surface associated -0.0267745
SORBS2 sorbin and SH3 domain containing 2 -0.0267382
MX1 MX dynamin-like GTPase 1 -0.026606
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0265874
OXSR1 oxidative stress responsive 1 -0.0264533
C3 complement component 3 -0.0262619
S100A11 S100 calcium binding protein A11 -0.0261599
ADGRF1 adhesion G protein-coupled receptor F1 -0.0259422
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0256972
ALCAM activated leukocyte cell adhesion molecule -0.0249646
RPLP1 ribosomal protein, large, P1 -0.0246143
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0245816
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0243662
S100A6 S100 calcium binding protein A6 -0.0242253
PDE4D phosphodiesterase 4D, cAMP-specific -0.0241575
MT2A metallothionein 2A -0.0240286
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0238355
TMOD3 tropomodulin 3 (ubiquitous) -0.0237047
JUP junction plakoglobin -0.0236522
LAMA5 laminin, alpha 5 -0.023397
IFIH1 interferon induced with helicase C domain 1 -0.023395
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.023385
CCND1 cyclin D1 -0.0233532
STS steroid sulfatase (microsomal), isozyme S -0.0233299
VIM vimentin -0.0229968
ACTN4 actinin, alpha 4 -0.0227695
HDAC9 histone deacetylase 9 -0.0226081
BPTF bromodomain PHD finger transcription factor -0.0225955
MYOF myoferlin -0.0223516
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0221975
FCHSD2 FCH and double SH3 domains 2 -0.0220498
BCL2L1 BCL2-like 1 -0.0218906
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0217131
ACTG1 actin gamma 1 -0.0216922
IFI44 interferon-induced protein 44 -0.0215685
NRP1 neuropilin 1 -0.0212281
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0210732
MELTF melanotransferrin -0.0210302
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0208757
SVIL supervillin -0.0208174
PKM pyruvate kinase, muscle -0.0206903
ANO1 anoctamin 1, calcium activated chloride channel -0.0206104
S100A10 S100 calcium binding protein A10 -0.0205826