| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD6 | FERM domain containing 6 | 0.195476 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.115838 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.109189 |
| EXT1 | exostosin glycosyltransferase 1 | 0.107973 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.104789 |
| RPS12 | ribosomal protein S12 | 0.104655 |
| HDAC9 | histone deacetylase 9 | 0.104192 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0988682 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0864417 |
| NAV2 | neuron navigator 2 | 0.0784036 |
| RPS3 | ribosomal protein S3 | 0.0778527 |
| NAV3 | neuron navigator 3 | 0.0757825 |
| FRMD4A | FERM domain containing 4A | 0.0691786 |
| RPL37A | ribosomal protein L37a | 0.0684585 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0658998 |
| RPL26 | ribosomal protein L26 | 0.0657198 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0656061 |
| SGMS2 | sphingomyelin synthase 2 | 0.0652311 |
| INTS6 | integrator complex subunit 6 | 0.0643965 |
| RPS8 | ribosomal protein S8 | 0.0620954 |
| NABP1 | nucleic acid binding protein 1 | 0.0620341 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0590643 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0571752 |
| HMGA2 | high mobility group AT-hook 2 | 0.057042 |
| RPL13A | ribosomal protein L13a | 0.0543822 |
| EFNB2 | ephrin-B2 | 0.051128 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0511112 |
| RUNX1 | runt-related transcription factor 1 | 0.0509195 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0499997 |
| MCL1 | myeloid cell leukemia 1 | 0.0499853 |
| EGR1 | early growth response 1 | 0.0491129 |
| RPL35A | ribosomal protein L35a | 0.0489843 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0465406 |
| ZNF438 | zinc finger protein 438 | 0.044691 |
| FLNB | filamin B, beta | 0.0434427 |
| RPL7A | ribosomal protein L7a | 0.0429156 |
| RCOR1 | REST corepressor 1 | 0.0417878 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0411877 |
| JMJD1C | jumonji domain containing 1C | 0.0411724 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0394791 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0390368 |
| HMGA1 | high mobility group AT-hook 1 | 0.0387011 |
| RPS2 | ribosomal protein S2 | 0.0386566 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0378183 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0376463 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0368784 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0358202 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0346254 |
| RPS29 | ribosomal protein S29 | 0.0342951 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0336997 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0336189 |
| SQSTM1 | sequestosome 1 | 0.0332737 |
| RPL9 | ribosomal protein L9 | 0.0332598 |
| ADTRP | androgen-dependent TFPI-regulating protein | 0.0328939 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0328823 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0327804 |
| CORO1C | coronin, actin binding protein, 1C | 0.0326213 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0321163 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0314773 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0308014 |
| DGKI | diacylglycerol kinase, iota | 0.0306178 |
| RPS27A | ribosomal protein S27a | 0.0301297 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0296248 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0292254 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0287592 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0284071 |
| GPATCH2L | G patch domain containing 2-like | 0.0282122 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.027786 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0275472 |
| RPS25 | ribosomal protein S25 | 0.0269945 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0265779 |
| RPL6 | ribosomal protein L6 | 0.0256933 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0256906 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.0256574 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0255894 |
| ANK2 | ankyrin 2, neuronal | 0.0255288 |
| MT2A | metallothionein 2A | 0.0254157 |
| RPS17 | ribosomal protein S17 | 0.025411 |
| RPS13 | ribosomal protein S13 | 0.0253282 |
| CUTC | cutC copper transporter | 0.0250013 |
| RPL38 | ribosomal protein L38 | 0.0246971 |
| CAPRIN2 | caprin family member 2 | 0.0244815 |
| CMIP | c-Maf inducing protein | 0.0242929 |
| SP100 | SP100 nuclear antigen | 0.0223807 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0222632 |
| PRKCE | protein kinase C, epsilon | 0.021677 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0216137 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0215267 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0214262 |
| RACK1 | receptor for activated C kinase 1 | 0.0211882 |
| RPL12 | ribosomal protein L12 | 0.0211405 |
| IGF2 | insulin-like growth factor 2 | 0.0207578 |
| ERCC1 | excision repair cross-complementation group 1 | 0.020723 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0207114 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0206767 |
| RPS10 | ribosomal protein S10 | 0.0206509 |
| SMYD3 | SET and MYND domain containing 3 | 0.0206342 |
| RPS27 | ribosomal protein S27 | 0.0204962 |
| RPL36A | ribosomal protein L36a | 0.0203723 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0203564 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.064097 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0636283 |
| RPLP1 | ribosomal protein, large, P1 | -0.0557367 |
| CALD1 | caldesmon 1 | -0.0503815 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0482824 |
| PTMA | prothymosin, alpha | -0.0482156 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0452102 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0415196 |
| TMSB10 | thymosin beta 10 | -0.0406936 |
| RAD21 | RAD21 homolog (S. pombe) | -0.039063 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0369658 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0354636 |
| DIAPH3 | diaphanous-related formin 3 | -0.0351187 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0325801 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0325024 |
| RBM39 | RNA binding motif protein 39 | -0.0299535 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0296376 |
| RBM25 | RNA binding motif protein 25 | -0.0295262 |
| PKM | pyruvate kinase, muscle | -0.0291786 |
| RPLP0 | ribosomal protein, large, P0 | -0.0290248 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.028843 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0287924 |
| POTEF | POTE ankyrin domain family, member F | -0.0287129 |
| ZNF292 | zinc finger protein 292 | -0.0286697 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.028064 |
| GNAS | GNAS complex locus | -0.0276651 |
| USP3 | ubiquitin specific peptidase 3 | -0.0269867 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0263023 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0259363 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0257937 |
| RPS4X | ribosomal protein S4, X-linked | -0.0255606 |
| RPS6 | ribosomal protein S6 | -0.0255101 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0248167 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0246425 |
| SETD5 | SET domain containing 5 | -0.024603 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0245914 |
| SEPTIN7 | septin 7 | -0.0245669 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0244461 |
| MATR3 | matrin 3 | -0.024383 |
| TNPO1 | transportin 1 | -0.0242082 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0241654 |
| KPNB1 | karyopherin (importin) beta 1 | -0.02388 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.023429 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0234084 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0232235 |
| RNF145 | ring finger protein 145 | -0.0229436 |
| SRPK2 | SRSF protein kinase 2 | -0.0227443 |
| TTR | transthyretin | -0.0226785 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0225693 |
| DEK | DEK proto-oncogene | -0.0225463 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0225436 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0225227 |
| RRBP1 | ribosome binding protein 1 | -0.0223136 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0221719 |
| TPX2 | TPX2, microtubule-associated | -0.0219017 |
| TMEM87A | transmembrane protein 87A | -0.0215536 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0215079 |
| TPM4 | tropomyosin 4 | -0.0213888 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0213385 |
| BBX | bobby sox homolog (Drosophila) | -0.0210469 |
| RPL32 | ribosomal protein L32 | -0.0209575 |
| NF1 | neurofibromin 1 | -0.0209085 |
| LDHB | lactate dehydrogenase B | -0.0207325 |
| CBX3 | chromobox homolog 3 | -0.0206801 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0204021 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0203904 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | -0.020126 |
| TRAM1 | translocation associated membrane protein 1 | -0.0200383 |
| XPO1 | exportin 1 | -0.0196859 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.019588 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0195676 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0193201 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0192448 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0192027 |
| ZFR | zinc finger RNA binding protein | -0.0191312 |
| TXNRD1 | thioredoxin reductase 1 | -0.0190201 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0188537 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0187049 |
| S100A2 | S100 calcium binding protein A2 | -0.018646 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0186107 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0185496 |
| CANX | calnexin | -0.0183259 |
| NPR2 | natriuretic peptide receptor 2 | -0.0182216 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0181371 |
| TCERG1 | transcription elongation regulator 1 | -0.0180665 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0180632 |
| WDR45B | WD repeat domain 45B | -0.0180555 |
| RLF | rearranged L-myc fusion | -0.0180234 |
| SMC4 | structural maintenance of chromosomes 4 | -0.017864 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0177873 |
| NUDCD1 | NudC domain containing 1 | -0.0177315 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0177187 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0176776 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0176694 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0176467 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0176271 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0176165 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0174648 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0172796 |
| GOLGA4 | golgin A4 | -0.0172185 |
