| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.150822 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.10044 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0968108 |
| HLA-B | major histocompatibility complex, class I, B | 0.0953547 |
| FAM20C | family with sequence similarity 20, member C | 0.0692321 |
| HMGA2 | high mobility group AT-hook 2 | 0.0625168 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0530065 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0520261 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0512481 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0511141 |
| HLA-C | major histocompatibility complex, class I, C | 0.0504626 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0489094 |
| LOXL2 | lysyl oxidase-like 2 | 0.0448873 |
| ASPH | aspartate beta-hydroxylase | 0.0416698 |
| RAI14 | retinoic acid induced 14 | 0.040317 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0400039 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0389771 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0387658 |
| FMNL2 | formin-like 2 | 0.0376469 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0376175 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0375647 |
| STK10 | serine/threonine kinase 10 | 0.0373839 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0371731 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0371717 |
| IL1B | interleukin 1, beta | 0.037135 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0355254 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0354645 |
| CD44 | CD44 molecule (Indian blood group) | 0.0343381 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0342339 |
| EGR1 | early growth response 1 | 0.0341692 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0340972 |
| IER3 | immediate early response 3 | 0.033514 |
| SP100 | SP100 nuclear antigen | 0.0334331 |
| SMYD3 | SET and MYND domain containing 3 | 0.0329638 |
| CTSB | cathepsin B | 0.0327771 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0325265 |
| SMAD3 | SMAD family member 3 | 0.0323914 |
| HPCAL1 | hippocalcin-like 1 | 0.0318509 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0318221 |
| CAVIN1 | caveolae associated protein 1 | 0.0316454 |
| RPL26 | ribosomal protein L26 | 0.0311751 |
| SQSTM1 | sequestosome 1 | 0.03079 |
| RASA3 | RAS p21 protein activator 3 | 0.0307094 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0306929 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0303478 |
| MCL1 | myeloid cell leukemia 1 | 0.0298146 |
| COL1A1 | collagen, type I, alpha 1 | 0.0294535 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0291316 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.029066 |
| XAF1 | XIAP associated factor 1 | 0.0288184 |
| USP34 | ubiquitin specific peptidase 34 | 0.0283137 |
| EMP1 | epithelial membrane protein 1 | 0.0281672 |
| MTSS1 | metastasis suppressor 1 | 0.0281573 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0281474 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0279682 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0279621 |
| INTS6 | integrator complex subunit 6 | 0.0277802 |
| RPL37A | ribosomal protein L37a | 0.0274593 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0274557 |
| THBS2 | thrombospondin 2 | 0.0271583 |
| ANGPTL4 | angiopoietin-like 4 | 0.0270437 |
| FNIP1 | folliculin interacting protein 1 | 0.0268105 |
| HLA-E | major histocompatibility complex, class I, E | 0.0267842 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0266959 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0260715 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0259008 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0256828 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0256691 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0253412 |
| AHNAK | AHNAK nucleoprotein | 0.0250258 |
| RPS8 | ribosomal protein S8 | 0.0245265 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0243633 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0242874 |
| AGBL1 | ATP/GTP binding protein-like 1 | 0.0238768 |
| RPL35A | ribosomal protein L35a | 0.0238461 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0237048 |
| NAV2 | neuron navigator 2 | 0.0236705 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0235461 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0233216 |
| CD109 | CD109 molecule | 0.0230434 |
| PCBP3 | poly(rC) binding protein 3 | 0.0229609 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0228248 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0225275 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0225001 |
| STK4 | serine/threonine kinase 4 | 0.0224313 |
| RPS25 | ribosomal protein S25 | 0.021829 |
| SYNDIG1 | synapse differentiation inducing 1 | 0.0216802 |
| FLNB | filamin B, beta | 0.0216566 |
| H2AC6 | H2A clustered histone 6 | 0.0215932 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0213753 |
| ANO6 | anoctamin 6 | 0.0212018 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0211557 |
| CCDC138 | coiled-coil domain containing 138 | 0.0209885 |
| RUNX1 | runt-related transcription factor 1 | 0.0209448 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0207128 |
| SEPTIN9 | septin 9 | 0.0207118 |
| LRRC23 | leucine rich repeat containing 23 | 0.0204152 |
| RPS27A | ribosomal protein S27a | 0.0202516 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0202457 |
| NABP1 | nucleic acid binding protein 1 | 0.0198881 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.332998 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.15152 |
| FN1 | fibronectin 1 | -0.118022 |
| TMSB10 | thymosin beta 10 | -0.0945789 |
| FTL | ferritin, light polypeptide | -0.0924165 |
| POTEF | POTE ankyrin domain family, member F | -0.0886882 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0862446 |
| B2M | beta-2-microglobulin | -0.0806518 |
| PKM | pyruvate kinase, muscle | -0.0716295 |
| NRP1 | neuropilin 1 | -0.0652515 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0540938 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.052203 |
| TPM1 | tropomyosin 1 (alpha) | -0.0485477 |
| S100A6 | S100 calcium binding protein A6 | -0.0466918 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0457037 |
| MEF2A | myocyte enhancer factor 2A | -0.0438797 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0434476 |
| DSTN | destrin (actin depolymerizing factor) | -0.042571 |
| UBC | ubiquitin C | -0.039344 |
| SETD5 | SET domain containing 5 | -0.0385324 |
| GOLGA4 | golgin A4 | -0.0382843 |
| CENPF | centromere protein F, 350/400kDa | -0.0379138 |
| LDHA | lactate dehydrogenase A | -0.0372228 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0367012 |
| CALD1 | caldesmon 1 | -0.0359493 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0355236 |
| RPS19 | ribosomal protein S19 | -0.0352077 |
| FRMD4A | FERM domain containing 4A | -0.0351413 |
| NDRG1 | N-myc downstream regulated 1 | -0.0348197 |
| MSN | moesin | -0.034715 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0318302 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0317185 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0317046 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.031618 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0309957 |
| ITGA11 | integrin, alpha 11 | -0.0307403 |
| TFG | TRK-fused gene | -0.0298834 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0297729 |
| CBX3 | chromobox homolog 3 | -0.0297379 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0291481 |
| TAGLN2 | transgelin 2 | -0.0287908 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0287531 |
| PFN1 | profilin 1 | -0.0284446 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0283421 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0282078 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.028063 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0277381 |
| SEPTIN7 | septin 7 | -0.0277106 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.027475 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0274597 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0274339 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0273579 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0267496 |
| TPM4 | tropomyosin 4 | -0.0267319 |
| TAPBP | TAP binding protein (tapasin) | -0.0267312 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0266488 |
| SON | SON DNA binding protein | -0.0265701 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0260711 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0259073 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0257249 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0256359 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0255439 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0254437 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0251622 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0250491 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.024885 |
| MYADM | myeloid-associated differentiation marker | -0.0247586 |
| NKTR | natural killer cell triggering receptor | -0.0247361 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0243527 |
| RTN4 | reticulon 4 | -0.0238851 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0237332 |
| TNS3 | tensin 3 | -0.0237021 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0236872 |
| TMEM87A | transmembrane protein 87A | -0.0234872 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.023424 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0233614 |
| TPX2 | TPX2, microtubule-associated | -0.0232124 |
| WASF2 | WAS protein family, member 2 | -0.0231426 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0229933 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0229325 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0228415 |
| C1R | complement component 1, r subcomponent | -0.0225271 |
| MKI67 | marker of proliferation Ki-67 | -0.0224752 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0222942 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0221786 |
| RPLP1 | ribosomal protein, large, P1 | -0.0219671 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0219134 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0217896 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0217618 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0217404 |
| SET | SET nuclear proto-oncogene | -0.0217221 |
| RPS6 | ribosomal protein S6 | -0.0216081 |
| AXL | AXL receptor tyrosine kinase | -0.021561 |
| TPI1 | triosephosphate isomerase 1 | -0.0215085 |
| ACTN4 | actinin, alpha 4 | -0.0214648 |
| FAM193A | family with sequence similarity 193, member A | -0.0214526 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0214229 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0213649 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0212901 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0211689 |
