| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.164512 |
| PDE10A | phosphodiesterase 10A | 0.135478 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0945062 |
| INHBA | inhibin, beta A | 0.07561 |
| FNDC3A | fibronectin type III domain containing 3A | 0.072636 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0700285 |
| STC1 | stanniocalcin 1 | 0.0649914 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0640345 |
| ENO1 | enolase 1, (alpha) | 0.062455 |
| MCL1 | myeloid cell leukemia 1 | 0.0621341 |
| NBEA | neurobeachin | 0.0587869 |
| VGF | VGF nerve growth factor inducible | 0.0503939 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0483603 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.048102 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0480292 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0474359 |
| SVIL | supervillin | 0.0458249 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0449568 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0422627 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0421046 |
| TPM3 | tropomyosin 3 | 0.0395047 |
| ZFHX3 | zinc finger homeobox 3 | 0.0394252 |
| CPE | carboxypeptidase E | 0.0388334 |
| SCG2 | secretogranin II | 0.0375598 |
| SIK2 | salt-inducible kinase 2 | 0.0374161 |
| CHGB | chromogranin B | 0.0357649 |
| RPS8 | ribosomal protein S8 | 0.03567 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0353316 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0344982 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0337221 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0334699 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0317731 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0316443 |
| RPL26 | ribosomal protein L26 | 0.0313544 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0311051 |
| CHGA | chromogranin A | 0.0309892 |
| CALCA | calcitonin-related polypeptide alpha | 0.0305822 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0304083 |
| DST | dystonin | 0.0300421 |
| RPS3 | ribosomal protein S3 | 0.0299516 |
| COL22A1 | collagen, type XXII, alpha 1 | 0.029889 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0283414 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.02765 |
| NDRG1 | N-myc downstream regulated 1 | 0.0275408 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0275272 |
| RNF213 | ring finger protein 213 | 0.0274517 |
| FAT1 | FAT atypical cadherin 1 | 0.0271476 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0261618 |
| RPS12 | ribosomal protein S12 | 0.0261553 |
| RPS6 | ribosomal protein S6 | 0.0257726 |
| PAEP | progestagen-associated endometrial protein | 0.0256922 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0256432 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0254317 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0251935 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0251844 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0251529 |
| MAP1B | microtubule-associated protein 1B | 0.0247392 |
| MT2A | metallothionein 2A | 0.0243132 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0240365 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | 0.0238777 |
| POTEF | POTE ankyrin domain family, member F | 0.0235586 |
| RPL37A | ribosomal protein L37a | 0.0233822 |
| RPL6 | ribosomal protein L6 | 0.0233669 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0233041 |
| SIK3 | SIK family kinase 3 | 0.023261 |
| CALR | calreticulin | 0.0232518 |
| RPS27 | ribosomal protein S27 | 0.0231636 |
| WWOX | WW domain containing oxidoreductase | 0.0229482 |
| RPL5 | ribosomal protein L5 | 0.0228218 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0228181 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.02276 |
| EGR1 | early growth response 1 | 0.0227449 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.022466 |
| ENSA | endosulfine alpha | 0.0223212 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0223183 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0222343 |
| SETX | senataxin | 0.0221406 |
| EGFR | epidermal growth factor receptor | 0.0219174 |
| RPL23 | ribosomal protein L23 | 0.021628 |
| RPL7 | ribosomal protein L7 | 0.0215602 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0213428 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0212922 |
| CDK13 | cyclin-dependent kinase 13 | 0.0208343 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.020521 |
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.0204098 |
| NANOS1 | nanos homolog 1 (Drosophila) | 0.0201903 |
| ELMO1 | engulfment and cell motility 1 | 0.0201082 |
| PUM3 | pumilio RNA binding family member 3 | 0.0196913 |
| RPL37 | ribosomal protein L37 | 0.0194882 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0194783 |
| PCBP2 | poly(rC) binding protein 2 | 0.0193633 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0192583 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0191413 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0190843 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0190319 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0189547 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0188433 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.018832 |
| IRS2 | insulin receptor substrate 2 | 0.0188256 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0184642 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TENM1 | teneurin transmembrane protein 1 | -0.144103 |
| ESRRG | estrogen-related receptor gamma | -0.0742114 |
| PTMA | prothymosin, alpha | -0.0708289 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0700252 |
| CENPF | centromere protein F, 350/400kDa | -0.0693371 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0641362 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0619938 |
| NRG1 | neuregulin 1 | -0.0582252 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0563727 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0488125 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0474091 |
| RIT2 | Ras-like without CAAX 2 | -0.0450844 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0430999 |
| PEG10 | paternally expressed 10 | -0.0427306 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0412682 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0400821 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0399017 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0383142 |
| CADM1 | cell adhesion molecule 1 | -0.037674 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0364595 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0327435 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0317865 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.0313092 |
| AGBL4 | ATP/GTP binding protein-like 4 | -0.0310387 |
| SYT1 | synaptotagmin I | -0.0305129 |
| SLC35F4 | solute carrier family 35, member F4 | -0.030105 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0299934 |
| ECT2 | epithelial cell transforming 2 | -0.0296928 |
| SGO2 | shugoshin 2 | -0.0296198 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0292148 |
| MKI67 | marker of proliferation Ki-67 | -0.0289787 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0289337 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0285169 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0262801 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0254912 |
| KNL1 | kinetochore scaffold 1 | -0.025276 |
| NFIA | nuclear factor I/A | -0.0250816 |
| RAD51B | RAD51 paralog B | -0.0248853 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0247564 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.024615 |
| CCDC88A | coiled-coil domain containing 88A | -0.0245291 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0244412 |
| TMSB4X | thymosin beta 4, X-linked | -0.0235743 |
| GPC5 | glypican 5 | -0.0233229 |
| JAM3 | junctional adhesion molecule 3 | -0.0228168 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0227395 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0226576 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0222799 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0222227 |
| TTK | TTK protein kinase | -0.0222202 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0216764 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0214873 |
| FGF14 | fibroblast growth factor 14 | -0.0213804 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.0213471 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0212844 |
| NELL1 | NEL-like 1 (chicken) | -0.0212502 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | -0.0210516 |
| ONECUT2 | one cut homeobox 2 | -0.0207546 |
| HMGB2 | high mobility group box 2 | -0.0206728 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0206597 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0205476 |
| HMGB1 | high mobility group box 1 | -0.0204899 |
| DIAPH3 | diaphanous-related formin 3 | -0.0201312 |
| NLGN1 | neuroligin 1 | -0.019977 |
| SMYD3 | SET and MYND domain containing 3 | -0.0198901 |
| PHF21A | PHD finger protein 21A | -0.0195084 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0193136 |
| TUBB | tubulin, beta class I | -0.0191711 |
| MYT1L | myelin transcription factor 1-like | -0.0191043 |
| PBK | PDZ binding kinase | -0.019089 |
| DGKB | diacylglycerol kinase, beta 90kDa | -0.0190874 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -0.0190298 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0190238 |
| DTNA | dystrobrevin, alpha | -0.0188752 |
| CA8 | carbonic anhydrase VIII | -0.0188609 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0186874 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0185038 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0184653 |
| FBXO34 | F-box protein 34 | -0.0184449 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0184316 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0183179 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0181736 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0181501 |
| PCM1 | pericentriolar material 1 | -0.0181317 |
| MATR3 | matrin 3 | -0.018092 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.017965 |
| CDCA2 | cell division cycle associated 2 | -0.0178652 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0177988 |
| NCAM1 | neural cell adhesion molecule 1 | -0.0177142 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0176227 |
| MYEF2 | myelin expression factor 2 | -0.0175718 |
| OGA | O-GlcNAcase | -0.0175691 |
| HMGB3 | high mobility group box 3 | -0.0175286 |
| ZNF292 | zinc finger protein 292 | -0.01746 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0172978 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0172962 |
| TPX2 | TPX2, microtubule-associated | -0.0170994 |
| FOXC1 | forkhead box C1 | -0.0170155 |
| LIFR | leukemia inhibitory factor receptor alpha | -0.0165617 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.0165491 |
