Lapatinib ditosylate_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.106955
FMN1 formin 1 0.0920166
ANGPTL4 angiopoietin-like 4 0.0895503
NRG3 neuregulin 3 0.0841909
ENO1 enolase 1, (alpha) 0.0826181
ICAM1 intercellular adhesion molecule 1 0.0778098
RPS3 ribosomal protein S3 0.076381
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0726747
IGFBP3 insulin-like growth factor binding protein 3 0.0719333
IFI6 interferon, alpha-inducible protein 6 0.0714993
SQSTM1 sequestosome 1 0.0657751
HLA-B major histocompatibility complex, class I, B 0.064298
FLNA filamin A, alpha 0.0625885
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0591851
HDAC9 histone deacetylase 9 0.0588461
RNF213 ring finger protein 213 0.0530613
FRMD4A FERM domain containing 4A 0.051352
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0509556
RPS12 ribosomal protein S12 0.0495566
SEPTIN9 septin 9 0.0479801
CTSB cathepsin B 0.0479619
FNDC3B fibronectin type III domain containing 3B 0.0478787
DST dystonin 0.0476992
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0466248
BACE2 beta-site APP-cleaving enzyme 2 0.0466165
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0463713
RUNX1 runt-related transcription factor 1 0.0459591
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0453304
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.044078
ZBTB20 zinc finger and BTB domain containing 20 0.0416983
NLGN1 neuroligin 1 0.0414266
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0410703
SVIL supervillin 0.0396356
TM4SF1 transmembrane 4 L six family member 1 0.0395593
MT2A metallothionein 2A 0.0393331
EEF2 eukaryotic translation elongation factor 2 0.0392542
NAV2 neuron navigator 2 0.0392471
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0391514
IGF1R insulin-like growth factor 1 receptor 0.0385273
TPM3 tropomyosin 3 0.0379633
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0371251
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0364979
ZMIZ1 zinc finger, MIZ-type containing 1 0.0364268
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0363075
HSPA8 heat shock 70kDa protein 8 0.036155
APOD apolipoprotein D 0.0359625
IFI44L interferon-induced protein 44-like 0.0357283
CD59 CD59 molecule, complement regulatory protein 0.0352402
PLEC plectin 0.0349939
HDAC4 histone deacetylase 4 0.0349566
NDRG1 N-myc downstream regulated 1 0.0344535
KDM4C lysine (K)-specific demethylase 4C 0.0343533
FOXP1 forkhead box P1 0.0340752
RPS13 ribosomal protein S13 0.0338328
ATXN1 ataxin 1 0.0335741
GOLGB1 golgin B1 0.0335565
RPS8 ribosomal protein S8 0.0335289
MELTF melanotransferrin 0.033223
SP100 SP100 nuclear antigen 0.0329307
GRID2 glutamate receptor, ionotropic, delta 2 0.0328737
STK10 serine/threonine kinase 10 0.0327159
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.032135
ASPH aspartate beta-hydroxylase 0.0319825
SMAD3 SMAD family member 3 0.0309821
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0307489
RPS27A ribosomal protein S27a 0.030675
LPP LIM domain containing preferred translocation partner in lipoma 0.0306402
MYH9 myosin, heavy chain 9, non-muscle 0.0303974
RPL37A ribosomal protein L37a 0.0298522
NRP2 neuropilin 2 0.0298155
EHBP1 EH domain binding protein 1 0.0294343
PTPRG protein tyrosine phosphatase, receptor type, G 0.0294148
FHIT fragile histidine triad 0.0291561
HLA-A major histocompatibility complex, class I, A 0.029147
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0288511
ACTN4 actinin, alpha 4 0.0284287
ADAR adenosine deaminase, RNA-specific 0.0283991
NOTCH2 notch 2 0.0280552
CCND1 cyclin D1 0.0278629
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0275898
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0268712
MCL1 myeloid cell leukemia 1 0.0266195
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0266107
LINGO2 leucine rich repeat and Ig domain containing 2 0.0265572
MACF1 microtubule-actin crosslinking factor 1 0.0262818
NAV1 neuron navigator 1 0.0262056
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0259713
TENM3 teneurin transmembrane protein 3 0.0259477
POTEF POTE ankyrin domain family, member F 0.0257934
RPL23 ribosomal protein L23 0.0253461
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0252625
KLF6 Kruppel-like factor 6 0.0252455
PMP22 peripheral myelin protein 22 0.0252154
FLNB filamin B, beta 0.025173
B2M beta-2-microglobulin 0.0250778
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0249574
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0249469
BPTF bromodomain PHD finger transcription factor 0.0248465
HMG20B high mobility group 20B 0.0241374
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0241071

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.203343
FN1 fibronectin 1 -0.178017
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.104015
GARS1 glycyl-tRNA synthetase 1 -0.0823414
GOLGA4 golgin A4 -0.0787144
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0707976
PTMA prothymosin, alpha -0.0622068
SPAG9 sperm associated antigen 9 -0.0614705
SETD5 SET domain containing 5 -0.0555571
FTL ferritin, light polypeptide -0.0537973
NAMPT nicotinamide phosphoribosyltransferase -0.0525485
VIM vimentin -0.0518168
CLINT1 clathrin interactor 1 -0.0512917
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0485939
QKI QKI, KH domain containing, RNA binding -0.0475744
CHD1 chromodomain helicase DNA binding protein 1 -0.0458613
TRIM33 tripartite motif containing 33 -0.0442888
LCORL ligand dependent nuclear receptor corepressor-like -0.0440173
ANKRD28 ankyrin repeat domain 28 -0.0434681
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0426727
ZFAND3 zinc finger, AN1-type domain 3 -0.0425548
MORF4L2 mortality factor 4 like 2 -0.0424401
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.042037
TSC22D2 TSC22 domain family, member 2 -0.0418303
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0416966
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0409392
CANX calnexin -0.0408167
TFG TRK-fused gene -0.0401209
USP3 ubiquitin specific peptidase 3 -0.0400476
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0391785
TENM1 teneurin transmembrane protein 1 -0.0388375
HELZ helicase with zinc finger -0.0370359
BIRC6 baculoviral IAP repeat containing 6 -0.0368532
ANLN anillin, actin binding protein -0.0368192
CENPF centromere protein F, 350/400kDa -0.035773
WAC WW domain containing adaptor with coiled-coil -0.0356599
TKT transketolase -0.0348491
ZFAND6 zinc finger, AN1-type domain 6 -0.034462
MATR3 matrin 3 -0.0342361
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0339794
TRA2A transformer 2 alpha homolog (Drosophila) -0.0335004
OLA1 Obg-like ATPase 1 -0.0334662
ADAM17 ADAM metallopeptidase domain 17 -0.0330811
EIF1 eukaryotic translation initiation factor 1 -0.0329648
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0326522
SREBF2 sterol regulatory element binding transcription factor 2 -0.0316089
RNF145 ring finger protein 145 -0.0315871
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0315293
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0314299
NF1 neurofibromin 1 -0.0312523
CSDE1 cold shock domain containing E1, RNA-binding -0.0310895
KAZN kazrin, periplakin interacting protein -0.0309588
ZNF292 zinc finger protein 292 -0.0305979
IARS1 isoleucyl-tRNA synthetase 1 -0.0305236
ZMYM2 zinc finger, MYM-type 2 -0.0304535
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0304092
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0300959
SBF2 SET binding factor 2 -0.0300318
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0298322
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0297217
KMT2E lysine (K)-specific methyltransferase 2E -0.0296862
PUM2 pumilio RNA-binding family member 2 -0.0295369
PTBP2 polypyrimidine tract binding protein 2 -0.0292851
RLF rearranged L-myc fusion -0.0292809
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0292766
NPEPPS aminopeptidase puromycin sensitive -0.0290556
OGA O-GlcNAcase -0.0289602
BRWD3 bromodomain and WD repeat domain containing 3 -0.0288243
THOC2 THO complex 2 -0.0288134
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -0.0285507
RAD21 RAD21 homolog (S. pombe) -0.0283353
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0281649
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0280929
CDC73 cell division cycle 73 -0.0280305
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0279662
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0278365
NKTR natural killer cell triggering receptor -0.0276668
ZC3H15 zinc finger CCCH-type containing 15 -0.0271795
COPA coatomer protein complex, subunit alpha -0.0268103
WDR45B WD repeat domain 45B -0.0265886
TUBB tubulin, beta class I -0.0265733
ABI1 abl-interactor 1 -0.0265355
KDM3A lysine (K)-specific demethylase 3A -0.0264788
NPR2 natriuretic peptide receptor 2 -0.0264349
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0263525
XPO1 exportin 1 -0.0260822
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0259844
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0256532
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0255892
RBM39 RNA binding motif protein 39 -0.0255625
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.025267
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0251355
OXSR1 oxidative stress responsive 1 -0.0249426
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0248252
NOP58 NOP58 ribonucleoprotein -0.0248068
TMEM263 transmembrane protein 263 -0.0247862
LSAMP limbic system-associated membrane protein -0.0246917
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.024649
NEMF nuclear export mediator factor -0.024616
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0244118