| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.131388 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0998842 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0890301 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0889332 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0782276 |
| MT2A | metallothionein 2A | 0.072186 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0693585 |
| RPS12 | ribosomal protein S12 | 0.0687826 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0682953 |
| PDE10A | phosphodiesterase 10A | 0.0681077 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0678032 |
| COL6A3 | collagen, type VI, alpha 3 | 0.067576 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0636106 |
| HDAC9 | histone deacetylase 9 | 0.0630399 |
| NDRG1 | N-myc downstream regulated 1 | 0.0623595 |
| NAV2 | neuron navigator 2 | 0.0611988 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0611616 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0590296 |
| CD44 | CD44 molecule (Indian blood group) | 0.0562967 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0554988 |
| RND3 | Rho family GTPase 3 | 0.054774 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0537456 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0520857 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0516763 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0512144 |
| VEGFA | vascular endothelial growth factor A | 0.0509411 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0499931 |
| RPS3 | ribosomal protein S3 | 0.0495236 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0488167 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0462675 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0439513 |
| GLIS3 | GLIS family zinc finger 3 | 0.0438685 |
| CADM1 | cell adhesion molecule 1 | 0.043171 |
| SMAD3 | SMAD family member 3 | 0.0430745 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0426773 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0426621 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0423862 |
| RPL26 | ribosomal protein L26 | 0.0412302 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.040922 |
| AFF3 | AF4/FMR2 family, member 3 | 0.039598 |
| STC1 | stanniocalcin 1 | 0.0390757 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0387093 |
| CDH13 | cadherin 13 | 0.0384669 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0382425 |
| KYNU | kynureninase | 0.0369129 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0363579 |
| FMNL2 | formin-like 2 | 0.0353456 |
| RUNX1 | runt-related transcription factor 1 | 0.0352377 |
| SQSTM1 | sequestosome 1 | 0.035225 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.0351005 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0348432 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0344818 |
| ARRDC3 | arrestin domain containing 3 | 0.0334822 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0329206 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0323902 |
| ADM | adrenomedullin | 0.0313972 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0313839 |
| GOLGB1 | golgin B1 | 0.0309679 |
| INTS6 | integrator complex subunit 6 | 0.0307205 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0304085 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0301999 |
| RPS8 | ribosomal protein S8 | 0.0299212 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0297633 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0297238 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0296815 |
| RPL37A | ribosomal protein L37a | 0.0296627 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0295752 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.0294827 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0290245 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0289676 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0287732 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0284876 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0277724 |
| GPC6 | glypican 6 | 0.0275565 |
| HMGA2 | high mobility group AT-hook 2 | 0.027411 |
| MLPH | melanophilin | 0.0272544 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0263684 |
| FNIP1 | folliculin interacting protein 1 | 0.0262137 |
| RPL6 | ribosomal protein L6 | 0.0259556 |
| MT1X | metallothionein 1X | 0.0258796 |
| RPL13A | ribosomal protein L13a | 0.0257979 |
| PRELID2 | PRELI domain containing 2 | 0.0253764 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0252799 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.025046 |
| MCL1 | myeloid cell leukemia 1 | 0.0249283 |
| STC2 | stanniocalcin 2 | 0.0249278 |
| HLA-A | major histocompatibility complex, class I, A | 0.0247225 |
| FAM219A | family with sequence similarity 219, member A | 0.0243455 |
| LOX | lysyl oxidase | 0.024268 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0242213 |
| DUSP10 | dual specificity phosphatase 10 | 0.0241455 |
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.0239784 |
| EPHA6 | EPH receptor A6 | 0.0239212 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0236178 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.023526 |
| RPS2 | ribosomal protein S2 | 0.0234987 |
| CDK19 | cyclin-dependent kinase 19 | 0.0234277 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0233776 |
| ATXN1 | ataxin 1 | 0.0233759 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0232718 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.125061 |
| PTMA | prothymosin, alpha | -0.122149 |
| FRMD4A | FERM domain containing 4A | -0.106605 |
| IER3 | immediate early response 3 | -0.092291 |
| FTL | ferritin, light polypeptide | -0.0919731 |
| FN1 | fibronectin 1 | -0.0890559 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0815506 |
| TMSB10 | thymosin beta 10 | -0.0775635 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0752804 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0700896 |
| VIM | vimentin | -0.0700323 |
| VCL | vinculin | -0.0699363 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0587919 |
| RPLP1 | ribosomal protein, large, P1 | -0.0587086 |
| TPM4 | tropomyosin 4 | -0.058476 |
| COL1A1 | collagen, type I, alpha 1 | -0.0549714 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.05376 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0493788 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0490357 |
| RRBP1 | ribosome binding protein 1 | -0.0442662 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0441487 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.043778 |
| RPS4X | ribosomal protein S4, X-linked | -0.0437587 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0415465 |
| BICC1 | BicC family RNA binding protein 1 | -0.039183 |
| RPS6 | ribosomal protein S6 | -0.0381972 |
| GNAS | GNAS complex locus | -0.0379655 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0379334 |
| SEPTIN7 | septin 7 | -0.0374601 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0370175 |
| PLIN2 | perilipin 2 | -0.0368753 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0365037 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0362749 |
| RPS24 | ribosomal protein S24 | -0.0362356 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0347034 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0343481 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0339387 |
| RTN4 | reticulon 4 | -0.0336707 |
| RIGI | RNA sensor RIG-I | -0.0330076 |
| CALD1 | caldesmon 1 | -0.0317312 |
| SFTPA2 | surfactant protein A2 | -0.0307792 |
| KIF4A | kinesin family member 4A | -0.0302149 |
| CLIC4 | chloride intracellular channel 4 | -0.0301585 |
| OSMR | oncostatin M receptor | -0.0298862 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0297536 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0295696 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0291471 |
| QKI | QKI, KH domain containing, RNA binding | -0.0290766 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0287786 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0285483 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0285104 |
| COL1A2 | collagen, type I, alpha 2 | -0.0274551 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0265471 |
| MX1 | MX dynamin-like GTPase 1 | -0.0265289 |
| TXNRD1 | thioredoxin reductase 1 | -0.0263413 |
| MAP4 | microtubule-associated protein 4 | -0.0257797 |
| FRMD5 | FERM domain containing 5 | -0.0257189 |
| SP100 | SP100 nuclear antigen | -0.0257141 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0256941 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0255445 |
| KLHL5 | kelch-like family member 5 | -0.0252816 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0251634 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.024707 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0246834 |
| DIAPH3 | diaphanous-related formin 3 | -0.0245819 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0245312 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0245275 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0245196 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0244914 |
| CTSD | cathepsin D | -0.024479 |
| DEK | DEK proto-oncogene | -0.0244307 |
| PALLD | palladin, cytoskeletal associated protein | -0.0241924 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0241827 |
| SBF2 | SET binding factor 2 | -0.0240468 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0239165 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0237431 |
| FBXO32 | F-box protein 32 | -0.02348 |
| DIAPH2 | diaphanous-related formin 2 | -0.0234555 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0232831 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0231238 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0228815 |
| TPM1 | tropomyosin 1 (alpha) | -0.0227545 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0227115 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0226227 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.022584 |
| RPS19 | ribosomal protein S19 | -0.0225415 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0224033 |
| RBM25 | RNA binding motif protein 25 | -0.0222168 |
| TUBB | tubulin, beta class I | -0.0222022 |
| NF1 | neurofibromin 1 | -0.0218081 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0217128 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0214395 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0212026 |
| TMSB4X | thymosin beta 4, X-linked | -0.0211936 |
| CAVIN1 | caveolae associated protein 1 | -0.0211922 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0209739 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0207291 |
| ACTG1 | actin gamma 1 | -0.0206385 |
| RPL32 | ribosomal protein L32 | -0.0205219 |
| CENPF | centromere protein F, 350/400kDa | -0.0204298 |
