| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.224864 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.149111 |
| NDRG1 | N-myc downstream regulated 1 | 0.137387 |
| FAM13A | family with sequence similarity 13, member A | 0.106483 |
| HLA-B | major histocompatibility complex, class I, B | 0.104943 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.103966 |
| ARRDC3 | arrestin domain containing 3 | 0.102401 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0921427 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0622717 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.061486 |
| MT2A | metallothionein 2A | 0.0606282 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0603585 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0589414 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0572315 |
| NRXN3 | neurexin 3 | 0.0571829 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0561967 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0556044 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0541997 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0533689 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0523847 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0520256 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0520025 |
| CALR | calreticulin | 0.051118 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0508227 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0499187 |
| COL5A1 | collagen, type V, alpha 1 | 0.0469687 |
| CADM1 | cell adhesion molecule 1 | 0.0455151 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0449662 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0448994 |
| ADM | adrenomedullin | 0.0436477 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0432432 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0430955 |
| AUTS2 | autism susceptibility candidate 2 | 0.0426728 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0424682 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0418626 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0410304 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0405567 |
| ZNF292 | zinc finger protein 292 | 0.0404011 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0403782 |
| COPA | coatomer protein complex, subunit alpha | 0.0390386 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0386267 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0365207 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0362225 |
| SCFD1 | sec1 family domain containing 1 | 0.0356366 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0355786 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0355082 |
| NOTCH2 | notch 2 | 0.035217 |
| HLA-C | major histocompatibility complex, class I, C | 0.0349113 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0348654 |
| PGM3 | phosphoglucomutase 3 | 0.0346455 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0339755 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0335031 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0332942 |
| VEGFA | vascular endothelial growth factor A | 0.0331564 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0331107 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0330502 |
| UBC | ubiquitin C | 0.0327324 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0323223 |
| FNIP1 | folliculin interacting protein 1 | 0.0321146 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0318384 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0317036 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0316031 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0312028 |
| GOLGA4 | golgin A4 | 0.0304928 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.030165 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0300387 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0294858 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0293106 |
| SMAD3 | SMAD family member 3 | 0.0290252 |
| ATP13A3 | ATPase type 13A3 | 0.0289362 |
| RPS12 | ribosomal protein S12 | 0.0287913 |
| STC1 | stanniocalcin 1 | 0.028679 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0286372 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0283387 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0283271 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0282229 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0280018 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0278902 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0278015 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0277934 |
| GOLGB1 | golgin B1 | 0.0277222 |
| TMF1 | TATA element modulatory factor 1 | 0.0275435 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0274307 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0271302 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0270869 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0270489 |
| COG5 | component of oligomeric golgi complex 5 | 0.0268074 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0268043 |
| MATR3 | matrin 3 | 0.0267688 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.026738 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0266507 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0265859 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0265331 |
| RND3 | Rho family GTPase 3 | 0.0264359 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0263398 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0262513 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0262496 |
| RYBP | RING1 and YY1 binding protein | 0.0257151 |
| GANAB | glucosidase, alpha; neutral AB | 0.0252782 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0251058 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.119853 |
| FN1 | fibronectin 1 | -0.10738 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0889951 |
| VIM | vimentin | -0.0841479 |
| COL1A2 | collagen, type I, alpha 2 | -0.0687478 |
| VCL | vinculin | -0.0678224 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0630257 |
| PTMA | prothymosin, alpha | -0.0602988 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0600757 |
| CALD1 | caldesmon 1 | -0.0594706 |
| COL1A1 | collagen, type I, alpha 1 | -0.0566419 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0531215 |
| SEPTIN7 | septin 7 | -0.0515078 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0491204 |
| TNS3 | tensin 3 | -0.0487256 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0470705 |
| PRSS23 | protease, serine, 23 | -0.0467048 |
| HMGA2 | high mobility group AT-hook 2 | -0.0464186 |
| CDH13 | cadherin 13 | -0.0452871 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0443238 |
| TPM4 | tropomyosin 4 | -0.0441274 |
| S100A6 | S100 calcium binding protein A6 | -0.0394224 |
| AHNAK | AHNAK nucleoprotein | -0.039368 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0386856 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0383494 |
| ASPH | aspartate beta-hydroxylase | -0.0382524 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0378316 |
| TPM1 | tropomyosin 1 (alpha) | -0.0377108 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0361502 |
| POTEF | POTE ankyrin domain family, member F | -0.0354645 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0341611 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0331425 |
| SMYD3 | SET and MYND domain containing 3 | -0.0330968 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0330599 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0329219 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0328591 |
| MAP1B | microtubule-associated protein 1B | -0.0328045 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.032786 |
| OSMR | oncostatin M receptor | -0.0327108 |
| CAVIN1 | caveolae associated protein 1 | -0.0324145 |
| LAMB1 | laminin, beta 1 | -0.0317272 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0314214 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0303468 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.030305 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0301669 |
| ENO1 | enolase 1, (alpha) | -0.0300203 |
| LOC112694756 | uncharaterized LOC112694756 | -0.029945 |
| TMSB4X | thymosin beta 4, X-linked | -0.0299268 |
| RRBP1 | ribosome binding protein 1 | -0.0297424 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0293029 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0287019 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0277332 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.027237 |
| PKM | pyruvate kinase, muscle | -0.026732 |
| XPO1 | exportin 1 | -0.0266183 |
| RAD51B | RAD51 paralog B | -0.0265133 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0264662 |
| GNAS | GNAS complex locus | -0.0262569 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0262497 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0260194 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0257115 |
| RPLP1 | ribosomal protein, large, P1 | -0.0254574 |
| MED13L | mediator complex subunit 13-like | -0.0252003 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0251181 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0245672 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0244039 |
| CALU | calumenin | -0.0243748 |
| ITGAV | integrin, alpha V | -0.0243531 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0243381 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0242098 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0241166 |
| PDE10A | phosphodiesterase 10A | -0.0240647 |
| DST | dystonin | -0.0237968 |
| INHBA | inhibin, beta A | -0.022979 |
| COL5A2 | collagen, type V, alpha 2 | -0.0216998 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0216617 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0215264 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0215077 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0213938 |
| USP47 | ubiquitin specific peptidase 47 | -0.0212869 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0211046 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0209189 |
| RAB31 | RAB31, member RAS oncogene family | -0.0208869 |
| RPL31 | ribosomal protein L31 | -0.0206445 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.020558 |
| RAI14 | retinoic acid induced 14 | -0.0205141 |
| ITM2B | integral membrane protein 2B | -0.0203344 |
| ANXA2 | annexin A2 | -0.0203146 |
| TUBA1B | tubulin, alpha 1b | -0.0201634 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0201261 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0200176 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0199141 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0198852 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0198116 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0197714 |
| EVI5 | ecotropic viral integration site 5 | -0.0197083 |
| CENPF | centromere protein F, 350/400kDa | -0.0196671 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0196439 |
| RPN2 | ribophorin II | -0.0196232 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0195869 |
