| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | 0.105461 |
| STC2 | stanniocalcin 2 | 0.0954122 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0666886 |
| HMGA2 | high mobility group AT-hook 2 | 0.064179 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0621664 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0572846 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0568384 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0559959 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0509119 |
| ASPH | aspartate beta-hydroxylase | 0.0499672 |
| INTS6 | integrator complex subunit 6 | 0.0493352 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0487287 |
| EFNA5 | ephrin-A5 | 0.0451048 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0442105 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0438534 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0400426 |
| MCL1 | myeloid cell leukemia 1 | 0.0362949 |
| ENO1 | enolase 1, (alpha) | 0.0352217 |
| RPS12 | ribosomal protein S12 | 0.0347032 |
| POTEF | POTE ankyrin domain family, member F | 0.0321208 |
| CTBP2 | C-terminal binding protein 2 | 0.0317448 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0287273 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0280896 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0274738 |
| HMGA1 | high mobility group AT-hook 1 | 0.0274514 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0273874 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0273718 |
| FAT1 | FAT atypical cadherin 1 | 0.0273439 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0264917 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0264603 |
| RAI14 | retinoic acid induced 14 | 0.0258086 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0256627 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0256004 |
| POU2F2 | POU class 2 homeobox 2 | 0.0251458 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0242795 |
| FOSL1 | FOS-like antigen 1 | 0.0234058 |
| ACTG1 | actin gamma 1 | 0.0232109 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0229746 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0228609 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0226648 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0225272 |
| IGF2 | insulin-like growth factor 2 | 0.0224624 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0222653 |
| LRRC23 | leucine rich repeat containing 23 | 0.0218887 |
| LOXL2 | lysyl oxidase-like 2 | 0.0215418 |
| FGF18 | fibroblast growth factor 18 | 0.0215223 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0213594 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0213284 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0210443 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0209968 |
| FLNA | filamin A, alpha | 0.0207281 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0207153 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0206636 |
| MTSS1 | metastasis suppressor 1 | 0.0206554 |
| TENM4 | teneurin transmembrane protein 4 | 0.0206051 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0205641 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0198808 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0193436 |
| VEGFA | vascular endothelial growth factor A | 0.0193181 |
| FLNB | filamin B, beta | 0.0189142 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.018554 |
| EGFR | epidermal growth factor receptor | 0.0185238 |
| FAM13A | family with sequence similarity 13, member A | 0.0181815 |
| TUFT1 | tuftelin 1 | 0.0179563 |
| RPS3 | ribosomal protein S3 | 0.0179295 |
| FAM107B | family with sequence similarity 107, member B | 0.0173615 |
| DUSP6 | dual specificity phosphatase 6 | 0.017217 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0171508 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0171221 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0171061 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0170707 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0169672 |
| EGR1 | early growth response 1 | 0.0169163 |
| TPM3 | tropomyosin 3 | 0.0166813 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0166628 |
| AGO2 | argonaute RISC catalytic component 2 | 0.016302 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0162851 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0162479 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.0161779 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0161016 |
| ABR | active BCR-related | 0.0158615 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0154619 |
| BAIAP2 | BAI1-associated protein 2 | 0.0154338 |
| MLPH | melanophilin | 0.0154315 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0153427 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0153337 |
| TGFA | transforming growth factor, alpha | 0.0152731 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0150924 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0150842 |
| CRTAC1 | cartilage acidic protein 1 | 0.0149509 |
| TGFB1 | transforming growth factor, beta 1 | 0.0147774 |
| MUSK | muscle, skeletal, receptor tyrosine kinase | 0.0146992 |
| ITGB4 | integrin, beta 4 | 0.0146448 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0145512 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0144772 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0144603 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0144424 |
| KLHL29 | kelch-like family member 29 | 0.0142336 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0140918 |
| UPP1 | uridine phosphorylase 1 | 0.0140718 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.259602 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.200861 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.155904 |
| PTMA | prothymosin, alpha | -0.128058 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.113854 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.111967 |
| CANX | calnexin | -0.098574 |
| OSMR | oncostatin M receptor | -0.094551 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0757723 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0695421 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.067031 |
| OGA | O-GlcNAcase | -0.0669189 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0643867 |
| RBM39 | RNA binding motif protein 39 | -0.0640019 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0637441 |
| RPS6 | ribosomal protein S6 | -0.0624074 |
| VCL | vinculin | -0.0602073 |
| FN1 | fibronectin 1 | -0.0601437 |
| TMSB10 | thymosin beta 10 | -0.0595748 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0582616 |
| AHR | aryl hydrocarbon receptor | -0.0563715 |
| CENPF | centromere protein F, 350/400kDa | -0.0554029 |
| RPLP1 | ribosomal protein, large, P1 | -0.0542251 |
| TXNIP | thioredoxin interacting protein | -0.0531277 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0514281 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0510543 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0504004 |
| MT2A | metallothionein 2A | -0.0503 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0500582 |
| FTL | ferritin, light polypeptide | -0.0494711 |
| S100A6 | S100 calcium binding protein A6 | -0.0492032 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0485377 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0473838 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0472137 |
| TXNRD1 | thioredoxin reductase 1 | -0.0464775 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0463499 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0462219 |
| VIM | vimentin | -0.0458689 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0451821 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0444889 |
| JMJD1C | jumonji domain containing 1C | -0.0442466 |
| RRBP1 | ribosome binding protein 1 | -0.0439749 |
| SMOX | spermine oxidase | -0.0434004 |
| NRP1 | neuropilin 1 | -0.0430048 |
| RBM25 | RNA binding motif protein 25 | -0.0427108 |
| FOXP1 | forkhead box P1 | -0.0423492 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0422118 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0421193 |
| ETNK1 | ethanolamine kinase 1 | -0.0417714 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0417072 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0412409 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0412137 |
| NEK7 | NIMA-related kinase 7 | -0.0410334 |
| FNBP1 | formin binding protein 1 | -0.0409025 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0408028 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0401561 |
| CEP350 | centrosomal protein 350kDa | -0.0395182 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0394299 |
| KLHL5 | kelch-like family member 5 | -0.0386604 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0385775 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0383125 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0379333 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0376656 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.037447 |
| SEPTIN7 | septin 7 | -0.0374336 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.037343 |
| TMEM156 | transmembrane protein 156 | -0.0369528 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0367701 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0367306 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0365424 |
| ITGA1 | integrin, alpha 1 | -0.0365178 |
| GOLGA4 | golgin A4 | -0.0365089 |
| NTN4 | netrin 4 | -0.0357862 |
| COPA | coatomer protein complex, subunit alpha | -0.0355594 |
| TPR | translocated promoter region, nuclear basket protein | -0.0354704 |
| FAF2 | Fas associated factor family member 2 | -0.0352518 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.035042 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0348164 |
| CAB39 | calcium binding protein 39 | -0.0347888 |
| RNF145 | ring finger protein 145 | -0.0347814 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.034516 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0345062 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0343961 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0342829 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0338904 |
| RPS24 | ribosomal protein S24 | -0.0337907 |
| IL6ST | interleukin 6 signal transducer | -0.0333336 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0332407 |
| CD44 | CD44 molecule (Indian blood group) | -0.0329774 |
| ZNF292 | zinc finger protein 292 | -0.0328144 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0327356 |
| SPAG9 | sperm associated antigen 9 | -0.0327204 |
| RPS19 | ribosomal protein S19 | -0.032444 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0322938 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0319619 |
| MKI67 | marker of proliferation Ki-67 | -0.0318972 |
| TOP1 | topoisomerase (DNA) I | -0.0318694 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0318595 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0317495 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0316403 |
