| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | 0.0984395 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0881169 |
| RPS12 | ribosomal protein S12 | 0.0711305 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0700355 |
| RPS3 | ribosomal protein S3 | 0.0692814 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0669469 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0664354 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0664098 |
| RPL37A | ribosomal protein L37a | 0.0610273 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0601797 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0591783 |
| RPL35A | ribosomal protein L35a | 0.0578904 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0549214 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0544049 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0543541 |
| RPL13A | ribosomal protein L13a | 0.0538343 |
| RPS25 | ribosomal protein S25 | 0.0502253 |
| RPS13 | ribosomal protein S13 | 0.0492893 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0468321 |
| RPL26 | ribosomal protein L26 | 0.0462862 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0451898 |
| YAP1 | Yes-associated protein 1 | 0.0426359 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0425567 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0418682 |
| NDRG1 | N-myc downstream regulated 1 | 0.0417179 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0417031 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0416811 |
| INTS6 | integrator complex subunit 6 | 0.0412614 |
| ANXA2 | annexin A2 | 0.0410506 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0408618 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0397885 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0397847 |
| VMP1 | vacuole membrane protein 1 | 0.0392479 |
| RPS27A | ribosomal protein S27a | 0.0390225 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0383477 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0379758 |
| CTBP2 | C-terminal binding protein 2 | 0.0376938 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0369168 |
| SMAD3 | SMAD family member 3 | 0.036342 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0361886 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0359532 |
| CUL3 | cullin 3 | 0.0353634 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0351715 |
| GOLGB1 | golgin B1 | 0.0349258 |
| RPLP2 | ribosomal protein, large, P2 | 0.0342912 |
| RPS29 | ribosomal protein S29 | 0.0342225 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0340859 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0338288 |
| RPL11 | ribosomal protein L11 | 0.0335683 |
| RPS21 | ribosomal protein S21 | 0.0333425 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.033337 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0331584 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0329894 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0329412 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0325677 |
| RPS17 | ribosomal protein S17 | 0.0317003 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0314945 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0314366 |
| STX3 | syntaxin 3 | 0.0313189 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0311495 |
| RPL23 | ribosomal protein L23 | 0.0308017 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0297515 |
| CDK13 | cyclin-dependent kinase 13 | 0.0293715 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0292121 |
| MED13L | mediator complex subunit 13-like | 0.0291451 |
| SQSTM1 | sequestosome 1 | 0.0290612 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0289674 |
| NEBL | nebulette | 0.0289507 |
| RPL15 | ribosomal protein L15 | 0.0288523 |
| FAM107B | family with sequence similarity 107, member B | 0.0288256 |
| RPS11 | ribosomal protein S11 | 0.0287733 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0287522 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0286203 |
| RPL7A | ribosomal protein L7a | 0.0283983 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0283274 |
| GNAS | GNAS complex locus | 0.0277603 |
| MYO1E | myosin IE | 0.0276202 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.0274412 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0274071 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0273864 |
| RPS8 | ribosomal protein S8 | 0.0268227 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0267466 |
| RUNX1 | runt-related transcription factor 1 | 0.0267358 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0266657 |
| HLA-B | major histocompatibility complex, class I, B | 0.026492 |
| GOLGA4 | golgin A4 | 0.0263791 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0263389 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0260063 |
| RPL9 | ribosomal protein L9 | 0.0256334 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0255901 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0254945 |
| EXT1 | exostosin glycosyltransferase 1 | 0.025484 |
| WWC1 | WW and C2 domain containing 1 | 0.0254426 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.025095 |
| RPL28 | ribosomal protein L28 | 0.0250758 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0250561 |
| NABP1 | nucleic acid binding protein 1 | 0.0247518 |
| ABHD5 | abhydrolase domain containing 5 | 0.0246879 |
| IRS2 | insulin receptor substrate 2 | 0.0246774 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0246553 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.096737 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0494804 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0475398 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0451053 |
| CENPF | centromere protein F, 350/400kDa | -0.0400975 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0392009 |
| TPX2 | TPX2, microtubule-associated | -0.0381783 |
| MACC1 | metastasis associated in colon cancer 1 | -0.037728 |
| H1-0 | H1.0 linker histone | -0.0334888 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0299948 |
| KRT18 | keratin 18, type I | -0.0297712 |
| MYOF | myoferlin | -0.0278751 |
| RBM25 | RNA binding motif protein 25 | -0.0247611 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0241089 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0225071 |
| XPO1 | exportin 1 | -0.0220159 |
| GPSM2 | G-protein signaling modulator 2 | -0.0213521 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0212408 |
| ASPH | aspartate beta-hydroxylase | -0.0201523 |
| AHNAK | AHNAK nucleoprotein | -0.0201362 |
| MKI67 | marker of proliferation Ki-67 | -0.0200102 |
| DIAPH3 | diaphanous-related formin 3 | -0.0197067 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0184783 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0177221 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0172548 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0166325 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0166231 |
| CST3 | cystatin C | -0.0165334 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.01652 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0164871 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0163236 |
| FRMD5 | FERM domain containing 5 | -0.0160851 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0160327 |
| IER3 | immediate early response 3 | -0.0158787 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0157895 |
| CENPE | centromere protein E, 312kDa | -0.0157543 |
| S100A6 | S100 calcium binding protein A6 | -0.0157528 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0153809 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0153777 |
| TUBB | tubulin, beta class I | -0.015333 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0150846 |
| KIF4A | kinesin family member 4A | -0.0148442 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0148258 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0148156 |
| CBX3 | chromobox homolog 3 | -0.0147375 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.014647 |
| SGO2 | shugoshin 2 | -0.0146173 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.014284 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0140057 |
| SVIL | supervillin | -0.0139105 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0137377 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -0.0136636 |
| HMGB1 | high mobility group box 1 | -0.0136512 |
| BRCA1 | breast cancer 1, early onset | -0.0134921 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0132905 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0132155 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0131598 |
| RASAL2 | RAS protein activator like 2 | -0.0131538 |
| KIF18A | kinesin family member 18A | -0.0130452 |
| TMEM123 | transmembrane protein 123 | -0.0129599 |
| KLF10 | Kruppel-like factor 10 | -0.0128321 |
| RDX | radixin | -0.0127669 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0127457 |
| KIF11 | kinesin family member 11 | -0.0127127 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0126106 |
| MIS18BP1 | MIS18 binding protein 1 | -0.012567 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0125576 |
| SEPTIN7 | septin 7 | -0.0125338 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0124001 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0123809 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0123662 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0122788 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0121659 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0121129 |
| FANCC | Fanconi anemia, complementation group C | -0.0120771 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0120004 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0119197 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0118521 |
| RTKN2 | rhotekin 2 | -0.0118458 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0118123 |
| CCNL1 | cyclin L1 | -0.0117261 |
| R3HDM1 | R3H domain containing 1 | -0.0117202 |
| KIF14 | kinesin family member 14 | -0.0116941 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0116842 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0116725 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0115557 |
| CEP295 | centrosomal protein 295kDa | -0.0114493 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0113087 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0113017 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.011226 |
| PKN2 | protein kinase N2 | -0.011201 |
| PHIP | pleckstrin homology domain interacting protein | -0.0111846 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0110988 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | -0.0110977 |
| TCERG1 | transcription elongation regulator 1 | -0.011073 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0110099 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0109039 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0108883 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.0108095 |
| RPLP1 | ribosomal protein, large, P1 | -0.0107486 |
