Lapatinib ditosylate_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lapatinib ditosylate perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lapatinib ditosylate_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATXN1 ataxin 1 0.138002
EGR1 early growth response 1 0.116443
TPT1 tumor protein, translationally-controlled 1 0.108388
EEF2 eukaryotic translation elongation factor 2 0.104675
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.104133
EGFR epidermal growth factor receptor 0.102959
HSPA8 heat shock 70kDa protein 8 0.102228
ACTG1 actin gamma 1 0.0909719
EMP1 epithelial membrane protein 1 0.0823398
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0712375
LAMC2 laminin, gamma 2 0.0694873
KLF6 Kruppel-like factor 6 0.0650321
ANXA2 annexin A2 0.0640511
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0621816
RPS8 ribosomal protein S8 0.0606904
TMSB10 thymosin beta 10 0.0599362
RPL35A ribosomal protein L35a 0.0595859
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.059558
AHNAK AHNAK nucleoprotein 0.0594765
RPL26 ribosomal protein L26 0.0592348
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0587543
CTSB cathepsin B 0.0580183
RPL23 ribosomal protein L23 0.0577588
CD36 CD36 molecule (thrombospondin receptor) 0.0567671
LDHA lactate dehydrogenase A 0.0561073
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0553176
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0552362
LAMA4 laminin, alpha 4 0.0546362
CLIP2 CAP-GLY domain containing linker protein 2 0.0543467
HMGA1 high mobility group AT-hook 1 0.0532861
EEF1G eukaryotic translation elongation factor 1 gamma 0.0526442
NCEH1 neutral cholesterol ester hydrolase 1 0.0524831
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0520609
ACTN4 actinin, alpha 4 0.0519464
SQSTM1 sequestosome 1 0.0518898
RPS12 ribosomal protein S12 0.0485339
CD9 CD9 molecule 0.0477403
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0474297
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0471433
FAT1 FAT atypical cadherin 1 0.0444123
RPL12 ribosomal protein L12 0.0436168
FHL2 four and a half LIM domains 2 0.0433797
ZHX2 zinc fingers and homeoboxes 2 0.0433467
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0423047
RPS3 ribosomal protein S3 0.0422674
RPL13A ribosomal protein L13a 0.0420964
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0415396
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0412747
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0409987
FTH1 ferritin, heavy polypeptide 1 0.0404476
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0402761
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0401825
RPL31 ribosomal protein L31 0.040161
LOC102724023 ES1 protein homolog, mitochondrial 0.0400048
MYO5B myosin VB 0.0387356
CANX calnexin 0.0385542
POTEF POTE ankyrin domain family, member F 0.0384189
BIRC3 baculoviral IAP repeat containing 3 0.0381554
UBC ubiquitin C 0.0379573
SGMS2 sphingomyelin synthase 2 0.037893
ZFP36L1 ZFP36 ring finger protein-like 1 0.0376533
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0371365
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0369395
SEPTIN9 septin 9 0.0368766
LOC112694756 uncharaterized LOC112694756 0.0368197
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0367975
ITPKC inositol-trisphosphate 3-kinase C 0.0367653
LMO7 LIM domain 7 0.0355967
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0355943
CALU calumenin 0.0352496
EXT1 exostosin glycosyltransferase 1 0.0351959
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0350671
DSG2 desmoglein 2 0.0347602
S100A6 S100 calcium binding protein A6 0.0346641
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0346163
NDRG1 N-myc downstream regulated 1 0.0335526
RPL5 ribosomal protein L5 0.0334234
SNX9 sorting nexin 9 0.0324418
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0324257
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.031761
EPHA2 EPH receptor A2 0.0315647
RPL34 ribosomal protein L34 0.031534
RPLP0 ribosomal protein, large, P0 0.0314829
SAMD4A sterile alpha motif domain containing 4A 0.0301276
RACK1 receptor for activated C kinase 1 0.0299885
FLNA filamin A, alpha 0.0299118
ENO1 enolase 1, (alpha) 0.0295721
LPP LIM domain containing preferred translocation partner in lipoma 0.0294979
RPS13 ribosomal protein S13 0.0294631
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0291524
RPS29 ribosomal protein S29 0.0280149
MACF1 microtubule-actin crosslinking factor 1 0.0279574
GCLC glutamate-cysteine ligase, catalytic subunit 0.0278721
CALR calreticulin 0.0278068
RPL35 ribosomal protein L35 0.0276609
RPS25 ribosomal protein S25 0.0274954
RPL36 ribosomal protein L36 0.0271766
CMIP c-Maf inducing protein 0.0268019
OSBPL10 oxysterol binding protein-like 10 0.0265022
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0260273

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.100077
RBM25 RNA binding motif protein 25 -0.0890739
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0880075
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0586136
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0565331
EREG epiregulin -0.0549224
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0511277
TOP1 topoisomerase (DNA) I -0.0510317
ITPRID2 ITPR interacting domain containing 2 -0.0487605
RBM39 RNA binding motif protein 39 -0.0447011
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0439145
GOLGA4 golgin A4 -0.0438761
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0434214
SETD5 SET domain containing 5 -0.0365057
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0358029
ZMYM2 zinc finger, MYM-type 2 -0.0351103
GARS1 glycyl-tRNA synthetase 1 -0.0349051
OSBPL3 oxysterol binding protein-like 3 -0.0347917
COG5 component of oligomeric golgi complex 5 -0.0327769
FERMT1 fermitin family member 1 -0.0321852
CCNL1 cyclin L1 -0.0319899
PDE4B phosphodiesterase 4B, cAMP-specific -0.0318788
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0318614
MTAP methylthioadenosine phosphorylase -0.0315237
PNISR PNN-interacting serine/arginine-rich protein -0.0311072
CDC73 cell division cycle 73 -0.030339
PDLIM5 PDZ and LIM domain 5 -0.0301108
PTBP2 polypyrimidine tract binding protein 2 -0.029935
BBX bobby sox homolog (Drosophila) -0.0297998
HDAC2 histone deacetylase 2 -0.0293093
GSK3B glycogen synthase kinase 3 beta -0.028895
TRA2A transformer 2 alpha homolog (Drosophila) -0.0286396
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0285022
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.028351
KDM6A lysine (K)-specific demethylase 6A -0.028221
BRWD1 bromodomain and WD repeat domain containing 1 -0.0280673
THSD4 thrombospondin, type I, domain containing 4 -0.0274518
EWSR1 EWS RNA-binding protein 1 -0.0272673
NEK7 NIMA-related kinase 7 -0.026331
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0251031
FNDC3B fibronectin type III domain containing 3B -0.0243035
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0238576
MED13L mediator complex subunit 13-like -0.0234499
SRSF11 serine/arginine-rich splicing factor 11 -0.0233599
RFX7 regulatory factor X, 7 -0.0233514
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0232428
SEC63 SEC63 homolog (S. cerevisiae) -0.0232342
RBM26 RNA binding motif protein 26 -0.0232075
ZFC3H1 zinc finger, C3H1-type containing -0.0229793
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0229262
PSPC1 paraspeckle component 1 -0.0227064
WAC WW domain containing adaptor with coiled-coil -0.0226277
SLMAP sarcolemma associated protein -0.022491
NCOR1 nuclear receptor corepressor 1 -0.0224194
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0222798
CEP152 centrosomal protein 152kDa -0.0221165
RANBP9 RAN binding protein 9 -0.0221085
SNX5 sorting nexin 5 -0.0221011
BIRC6 baculoviral IAP repeat containing 6 -0.0220385
PRRC2B proline-rich coiled-coil 2B -0.022004
THOC2 THO complex 2 -0.0219526
XPO1 exportin 1 -0.0216995
STRN3 striatin, calmodulin binding protein 3 -0.0216794
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0215524
KMT2E lysine (K)-specific methyltransferase 2E -0.0215029
ECPAS Ecm29 proteasome adaptor and scaffold -0.0214901
PTK2 protein tyrosine kinase 2 -0.0214448
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0210829
RNF145 ring finger protein 145 -0.0210393
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.020709
TXNRD1 thioredoxin reductase 1 -0.0204739
TCERG1 transcription elongation regulator 1 -0.0203279
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0201925
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0200865
ZNF207 zinc finger protein 207 -0.0199907
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0199029
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0198427
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0197297
NKTR natural killer cell triggering receptor -0.019726
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0196799
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0195179
ACBD6 acyl-CoA binding domain containing 6 -0.0194462
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.019421
UBAP2 ubiquitin associated protein 2 -0.0192333
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.01916
HOOK3 hook microtubule-tethering protein 3 -0.0191024
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.018959
SCAF8 SR-related CTD-associated factor 8 -0.0189589
MARS1 methionyl-tRNA synthetase 1 -0.0189079
ZBTB7C zinc finger and BTB domain containing 7C -0.0188635
RPS24 ribosomal protein S24 -0.0187762
NFIA nuclear factor I/A -0.018666
NOP58 NOP58 ribonucleoprotein -0.0186236
TMEM39A transmembrane protein 39A -0.0184809
SRPK1 SRSF protein kinase 1 -0.0184331
CD46 CD46 molecule, complement regulatory protein -0.0183845
KLF3 Kruppel-like factor 3 (basic) -0.0183268
ANKRD17 ankyrin repeat domain 17 -0.0182359
SFPQ splicing factor proline/glutamine-rich -0.0181379
SRRM1 serine/arginine repetitive matrix 1 -0.0178846