| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INTS6 | integrator complex subunit 6 | 0.0429766 |
| RPS12 | ribosomal protein S12 | 0.0363414 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0327779 |
| RPL26 | ribosomal protein L26 | 0.0312501 |
| RPL37A | ribosomal protein L37a | 0.0267455 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.024351 |
| HDAC4 | histone deacetylase 4 | 0.023941 |
| MT2A | metallothionein 2A | 0.0235589 |
| WWOX | WW domain containing oxidoreductase | 0.0230374 |
| SMAD3 | SMAD family member 3 | 0.0208785 |
| RPS3 | ribosomal protein S3 | 0.0188454 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0182513 |
| ASPH | aspartate beta-hydroxylase | 0.0178682 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0172211 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0166645 |
| PLEC | plectin | 0.0165165 |
| SYT1 | synaptotagmin I | 0.0160103 |
| RPS8 | ribosomal protein S8 | 0.01585 |
| RPS2 | ribosomal protein S2 | 0.0157766 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0157489 |
| TNS3 | tensin 3 | 0.0155631 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0149647 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0147926 |
| EGR1 | early growth response 1 | 0.0143022 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0141924 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.014032 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0136786 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0135809 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0134023 |
| EXOC4 | exocyst complex component 4 | 0.0127735 |
| RPL13A | ribosomal protein L13a | 0.0125691 |
| EFNB2 | ephrin-B2 | 0.0124118 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0121541 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0120332 |
| FAT1 | FAT atypical cadherin 1 | 0.0120304 |
| IGF2 | insulin-like growth factor 2 | 0.0119993 |
| MSN | moesin | 0.0119333 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0118974 |
| SPATA13 | spermatogenesis associated 13 | 0.011619 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0115907 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0115024 |
| MCC | mutated in colorectal cancers | 0.0114154 |
| MYO1E | myosin IE | 0.0112764 |
| RPS17 | ribosomal protein S17 | 0.0112262 |
| POTEF | POTE ankyrin domain family, member F | 0.011038 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0110315 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0109143 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0107806 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0107551 |
| CTSB | cathepsin B | 0.0106917 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0105802 |
| SIK3 | SIK family kinase 3 | 0.0105171 |
| COBL | cordon-bleu WH2 repeat protein | 0.0105142 |
| SEPTIN9 | septin 9 | 0.0104923 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0104031 |
| RPL6 | ribosomal protein L6 | 0.0103761 |
| FLNA | filamin A, alpha | 0.0103289 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0102682 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0101713 |
| CDHR3 | cadherin-related family member 3 | 0.0101523 |
| EGFR | epidermal growth factor receptor | 0.0101394 |
| NOP56 | NOP56 ribonucleoprotein | 0.0100099 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.00998385 |
| CLSTN2 | calsyntenin 2 | 0.00983835 |
| YAP1 | Yes-associated protein 1 | 0.00981886 |
| ATXN7L1 | ataxin 7-like 1 | 0.00975882 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.00968785 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.00960778 |
| GLI3 | GLI family zinc finger 3 | 0.00940747 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.00935347 |
| RAD51B | RAD51 paralog B | 0.00932687 |
| AFF1 | AF4/FMR2 family, member 1 | 0.00931882 |
| SLC38A2 | solute carrier family 38, member 2 | 0.00912521 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.00906162 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.00894644 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.00887205 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.00884985 |
| RPL35A | ribosomal protein L35a | 0.00870256 |
| AFAP1L2 | actin filament associated protein 1-like 2 | 0.00868878 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.00865579 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.00856302 |
| RPS29 | ribosomal protein S29 | 0.00855981 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 0.00848265 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.00844743 |
| NABP1 | nucleic acid binding protein 1 | 0.00839815 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.00832481 |
| RPS7 | ribosomal protein S7 | 0.00832289 |
| RCC1 | regulator of chromosome condensation 1 | 0.00831144 |
| RPL9 | ribosomal protein L9 | 0.00815035 |
| BMP5 | bone morphogenetic protein 5 | 0.00808234 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.00805669 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.00794554 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.00791026 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.00779472 |
| CD44 | CD44 molecule (Indian blood group) | 0.00778917 |
| BCL2L1 | BCL2-like 1 | 0.00777749 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.007722 |
| EPHB2 | EPH receptor B2 | 0.00770637 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.00768838 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.00762615 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.115125 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0691407 |
| KRT18 | keratin 18, type I | -0.0614022 |
| RPS6 | ribosomal protein S6 | -0.0610027 |
| TMSB10 | thymosin beta 10 | -0.0600433 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0593643 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0497526 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0471051 |
| PGK1 | phosphoglycerate kinase 1 | -0.0467984 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0460658 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.044799 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0446324 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0435899 |
| RBM39 | RNA binding motif protein 39 | -0.0431259 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0429284 |
| GOLGA4 | golgin A4 | -0.0401283 |
| H1-0 | H1.0 linker histone | -0.0399972 |
| AHNAK | AHNAK nucleoprotein | -0.0386967 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0386942 |
| OXR1 | oxidation resistance 1 | -0.0386282 |
| ANLN | anillin, actin binding protein | -0.0379037 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0378259 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0370065 |
| MORF4L2 | mortality factor 4 like 2 | -0.0367231 |
| RPLP1 | ribosomal protein, large, P1 | -0.0366545 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0353016 |
| ZNF292 | zinc finger protein 292 | -0.0350649 |
| RPS24 | ribosomal protein S24 | -0.0349286 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.034589 |
| CANX | calnexin | -0.0335937 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0331479 |
| JMJD1C | jumonji domain containing 1C | -0.0329859 |
| THOC2 | THO complex 2 | -0.0329383 |
| DIAPH3 | diaphanous-related formin 3 | -0.0320642 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0315512 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0315333 |
| PERP | PERP, TP53 apoptosis effector | -0.0314911 |
| OGA | O-GlcNAcase | -0.0306675 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0303271 |
| VIM | vimentin | -0.0301543 |
| NF1 | neurofibromin 1 | -0.0301494 |
| GLG1 | golgi glycoprotein 1 | -0.0295594 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0294101 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0291319 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0288442 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0285904 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0283884 |
| MATR3 | matrin 3 | -0.0280132 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0275918 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0273237 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0273035 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0272626 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0270321 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0269507 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0269449 |
| XPO1 | exportin 1 | -0.0269406 |
| RPLP0 | ribosomal protein, large, P0 | -0.0267331 |
| ITGA6 | integrin, alpha 6 | -0.0267058 |
| USP34 | ubiquitin specific peptidase 34 | -0.0267009 |
| ANXA2 | annexin A2 | -0.0264031 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0260883 |
| COG5 | component of oligomeric golgi complex 5 | -0.0260352 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0257279 |
| KRT8 | keratin 8, type II | -0.0254611 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0252394 |
| TPM4 | tropomyosin 4 | -0.0251882 |
| TMSB4X | thymosin beta 4, X-linked | -0.0250208 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.024396 |
| RPS4X | ribosomal protein S4, X-linked | -0.0238517 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0232552 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0231031 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0228294 |
| TMEM41B | transmembrane protein 41B | -0.0227791 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0226328 |
| SETD5 | SET domain containing 5 | -0.0225027 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0224656 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0221334 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0220946 |
| S100A6 | S100 calcium binding protein A6 | -0.0220322 |
| GNAS | GNAS complex locus | -0.0220273 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0219749 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0218967 |
| SBF2 | SET binding factor 2 | -0.0216337 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0215603 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0213472 |
| TPI1 | triosephosphate isomerase 1 | -0.0213091 |
| CENPF | centromere protein F, 350/400kDa | -0.0213056 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0210758 |
| STAG2 | stromal antigen 2 | -0.0209164 |
| CBX3 | chromobox homolog 3 | -0.0208224 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0208093 |
| RBM25 | RNA binding motif protein 25 | -0.0207678 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0207626 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0207011 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0205633 |
| RPL32 | ribosomal protein L32 | -0.0205546 |
| USP3 | ubiquitin specific peptidase 3 | -0.0205498 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0204146 |
| TPX2 | TPX2, microtubule-associated | -0.0201504 |
| NKTR | natural killer cell triggering receptor | -0.0199965 |
