| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lapatinib ditosylate perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lapatinib ditosylate_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.358534 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.188319 |
| HLA-B | major histocompatibility complex, class I, B | 0.116237 |
| HMGA2 | high mobility group AT-hook 2 | 0.115622 |
| CD44 | CD44 molecule (Indian blood group) | 0.109243 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0993851 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0918888 |
| MT2A | metallothionein 2A | 0.0877898 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0848999 |
| STC1 | stanniocalcin 1 | 0.0815662 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0739554 |
| MYO10 | myosin X | 0.0717078 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0698772 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0688214 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0668046 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0636782 |
| FMNL2 | formin-like 2 | 0.0611537 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0601178 |
| ASPH | aspartate beta-hydroxylase | 0.0572879 |
| RPS12 | ribosomal protein S12 | 0.0569594 |
| RPL37A | ribosomal protein L37a | 0.0558145 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0544817 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0542677 |
| RUNX1 | runt-related transcription factor 1 | 0.0534808 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0533914 |
| RPS8 | ribosomal protein S8 | 0.0531763 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.049453 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0477429 |
| PRELID2 | PRELI domain containing 2 | 0.0476497 |
| GLIS3 | GLIS family zinc finger 3 | 0.0464048 |
| MCL1 | myeloid cell leukemia 1 | 0.0459017 |
| INTS6 | integrator complex subunit 6 | 0.0456267 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0441238 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0435943 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0435393 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0417685 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0406062 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0392373 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0390159 |
| B2M | beta-2-microglobulin | 0.0389937 |
| HLA-A | major histocompatibility complex, class I, A | 0.0389271 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0372855 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0360314 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0359199 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0356069 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0350933 |
| RPS3 | ribosomal protein S3 | 0.0345051 |
| RPL35A | ribosomal protein L35a | 0.0344008 |
| RPL23 | ribosomal protein L23 | 0.0343021 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.034274 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0333139 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0330777 |
| RPL26 | ribosomal protein L26 | 0.0325891 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0324501 |
| NAV1 | neuron navigator 1 | 0.0321271 |
| IGF2 | insulin-like growth factor 2 | 0.0314429 |
| RPL13A | ribosomal protein L13a | 0.0309576 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0308875 |
| RASA2 | RAS p21 protein activator 2 | 0.0304226 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0304076 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0301802 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0295215 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0292374 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0290705 |
| NOTCH2 | notch 2 | 0.0288825 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0288074 |
| SNX9 | sorting nexin 9 | 0.028608 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0281361 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0280023 |
| ZNF638 | zinc finger protein 638 | 0.0276261 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0275112 |
| RPL9 | ribosomal protein L9 | 0.0273633 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.026995 |
| EGR1 | early growth response 1 | 0.0269249 |
| NAV2 | neuron navigator 2 | 0.0268261 |
| RPS17 | ribosomal protein S17 | 0.0262397 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0261558 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0254537 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0253472 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0250213 |
| SEPTIN9 | septin 9 | 0.0249843 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0245598 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0242169 |
| EGFR | epidermal growth factor receptor | 0.0240479 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0239657 |
| RPS27A | ribosomal protein S27a | 0.0237914 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0236491 |
| HLA-E | major histocompatibility complex, class I, E | 0.0234768 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0233932 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0233463 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0230195 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0229358 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0227939 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0227317 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0227124 |
| RPL11 | ribosomal protein L11 | 0.0226201 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0222499 |
| PTK2 | protein tyrosine kinase 2 | 0.0221975 |
| MYO1E | myosin IE | 0.0221445 |
| ARRDC3 | arrestin domain containing 3 | 0.0220824 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.184633 |
| VIM | vimentin | -0.182846 |
| COL6A3 | collagen, type VI, alpha 3 | -0.163242 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.137909 |
| COL1A1 | collagen, type I, alpha 1 | -0.136402 |
| INHBA | inhibin, beta A | -0.0919063 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0878491 |
| MMP1 | matrix metallopeptidase 1 | -0.0806692 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0795289 |
| COL1A2 | collagen, type I, alpha 2 | -0.078618 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0500961 |
| CAVIN1 | caveolae associated protein 1 | -0.0499885 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0488225 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0429088 |
| AHNAK | AHNAK nucleoprotein | -0.0422261 |
| CALD1 | caldesmon 1 | -0.041664 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0409924 |
| PTMA | prothymosin, alpha | -0.0395029 |
| TMSB10 | thymosin beta 10 | -0.0390401 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0383805 |
| S100A6 | S100 calcium binding protein A6 | -0.03764 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.036049 |
| TPM4 | tropomyosin 4 | -0.0359409 |
| RRBP1 | ribosome binding protein 1 | -0.0330086 |
| MAP1B | microtubule-associated protein 1B | -0.0327418 |
| HHIP | hedgehog interacting protein | -0.0320537 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0314079 |
| PRSS23 | protease, serine, 23 | -0.0300732 |
| H1-0 | H1.0 linker histone | -0.030053 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.029762 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0292679 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0290948 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0283994 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0282896 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0279481 |
| FBN1 | fibrillin 1 | -0.0273609 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0271217 |
| COL5A3 | collagen, type V, alpha 3 | -0.026943 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0269281 |
| COL4A1 | collagen, type IV, alpha 1 | -0.0260618 |
| FTL | ferritin, light polypeptide | -0.0258611 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0253075 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0247269 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0246537 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.024205 |
| RASAL2 | RAS protein activator like 2 | -0.0240893 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0240475 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0239576 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0239471 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0238894 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0238084 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0232651 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0231915 |
| RAI14 | retinoic acid induced 14 | -0.0231809 |
| GOLGA4 | golgin A4 | -0.0231601 |
| USP3 | ubiquitin specific peptidase 3 | -0.0227861 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0225261 |
| TMEM263 | transmembrane protein 263 | -0.0224247 |
| COPA | coatomer protein complex, subunit alpha | -0.0221196 |
| CCND1 | cyclin D1 | -0.022067 |
| PKM | pyruvate kinase, muscle | -0.0220261 |
| SETD5 | SET domain containing 5 | -0.0218465 |
| NKTR | natural killer cell triggering receptor | -0.0218101 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0214447 |
| DST | dystonin | -0.0213452 |
| TMSB4X | thymosin beta 4, X-linked | -0.021169 |
| HDLBP | high density lipoprotein binding protein | -0.0208644 |
| CALU | calumenin | -0.0206637 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0205131 |
| ATP13A3 | ATPase type 13A3 | -0.0205028 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0201414 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0196042 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0194822 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0194596 |
| HAS2 | hyaluronan synthase 2 | -0.0191837 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0191823 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.019138 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0191034 |
| CHSY3 | chondroitin sulfate synthase 3 | -0.0187559 |
| RTN4 | reticulon 4 | -0.0186818 |
| DSPP | dentin sialophosphoprotein | -0.0186651 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0186213 |
| SERINC3 | serine incorporator 3 | -0.0185601 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0185438 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0185106 |
| SEPTIN11 | septin 11 | -0.018233 |
| GOLGA2 | golgin A2 | -0.0182241 |
| RARS1 | arginyl-tRNA synthetase 1 | -0.0182118 |
| E2F7 | E2F transcription factor 7 | -0.0180843 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0180654 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0178792 |
| CENPF | centromere protein F, 350/400kDa | -0.017796 |
| ANXA2 | annexin A2 | -0.0177502 |
| TUBB6 | tubulin, beta 6 class V | -0.0176406 |
| RAI1 | retinoic acid induced 1 | -0.01764 |
| MMP12 | matrix metallopeptidase 12 | -0.0176205 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0176087 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.0175716 |
| PGK1 | phosphoglycerate kinase 1 | -0.0174766 |
| TCF12 | transcription factor 12 | -0.0173997 |
