Lapatinib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/208908
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Genes

199 proteins with high or low expression in Lapatinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
APOB apolipoprotein B 4.41
PAH phenylalanine hydroxylase 3.82
TMEM59 transmembrane protein 59 3.59
NDFIP1 Nedd4 family interacting protein 1 3.18
LAPTM4A lysosomal protein transmembrane 4 alpha 3.16
PLK4 polo-like kinase 4 2.79
ITM2B integral membrane protein 2B 2.67
APLP2 amyloid beta (A4) precursor-like protein 2 2.57
AREG amphiregulin 2.55
NRP1 neuropilin 1 2.45
ITM2C integral membrane protein 2C 2.42
LRP10 low density lipoprotein receptor-related protein 10 2.42
APOE apolipoprotein E 2.4
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.35
NBR1 neighbor of BRCA1 gene 1 2.33
GINM1 glycoprotein integral membrane 1 2.27
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.26
CTSL cathepsin L 2.19
SQSTM1 sequestosome 1 2.15
ANK2 ankyrin 2, neuronal 2.15
NCOA4 nuclear receptor coactivator 4 2.15
OSMR oncostatin M receptor 2.11
PSAP prosaposin 2.09
PLAU plasminogen activator, urokinase 2.09
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.07
HMOX1 heme oxygenase 1 2.05
NDFIP2 Nedd4 family interacting protein 2 2.04
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.01
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.98
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.97
LAMC2 laminin, gamma 2 1.95
FGF19 fibroblast growth factor 19 1.92
APP amyloid beta (A4) precursor protein 1.88
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 1.82
RNF149 ring finger protein 149 1.8
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.79
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.78
LDLR low density lipoprotein receptor 1.72
PLAUR plasminogen activator, urokinase receptor 1.7
IFNGR1 interferon gamma receptor 1 1.69
UPP1 uridine phosphorylase 1 1.69
IGFBP6 insulin-like growth factor binding protein 6 1.67
SDC4 syndecan 4 1.65
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.65
PCDHGA10 protocadherin gamma subfamily A, 10 1.65
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 1.63
STC2 stanniocalcin 2 1.63
LAMB3 laminin, beta 3 1.61
ANGPTL4 angiopoietin-like 4 1.58
HGFAC HGF activator 1.58
UGCG UDP-glucose ceramide glucosyltransferase 1.54
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.53
CALCOCO2 calcium binding and coiled-coil domain 2 1.53
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 1.5
TMEM200A transmembrane protein 200A 1.49
TMEM248 transmembrane protein 248 1.49
SLC38A2 solute carrier family 38, member 2 1.49
TSPAN3 tetraspanin 3 1.47
PIP prolactin-induced protein 1.47
TACSTD2 tumor-associated calcium signal transducer 2 1.46
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 1.46
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.44
MFGE8 milk fat globule-EGF factor 8 protein 1.41
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 1.4
GDF15 growth differentiation factor 15 1.4
TIMP1 TIMP metallopeptidase inhibitor 1 1.38
DEPTOR DEP domain containing MTOR-interacting protein 1.37
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 1.36
GRN granulin 1.35
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 1.34
JAG1 jagged 1 1.33
SLFN5 schlafen family member 5 1.33
CCPG1 cell cycle progression 1 1.32
ADGRG1 adhesion G protein-coupled receptor G1 1.31
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.3
ELOVL6 ELOVL fatty acid elongase 6 1.29
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.29
MFAP3L microfibrillar-associated protein 3-like 1.28
SERINC3 serine incorporator 3 1.26
PTPRS protein tyrosine phosphatase, receptor type, S 1.26
NIBAN1 niban apoptosis regulator 1 1.24
LRP11 low density lipoprotein receptor-related protein 11 1.22
TRIB3 tribbles pseudokinase 3 1.22
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.18
PLPP3 phospholipid phosphatase 3 1.18
TTYH2 tweety family member 2 1.16
RNF13 ring finger protein 13 1.16
FGFR4 fibroblast growth factor receptor 4 1.15
JUN jun proto-oncogene 1.14
SERINC1 serine incorporator 1 1.14
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.14
FGFBP1 fibroblast growth factor binding protein 1 1.13
PRNP prion protein 1.11
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.11
CD63 CD63 molecule 1.1
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.09
MFAP3 microfibrillar-associated protein 3 1.09
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.09
ERN1 endoplasmic reticulum to nucleus signaling 1 1.06
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 1.06

low expression

Symbol Name Standardized Value
LMOD1 leiomodin 1 (smooth muscle) -2.48
TBC1D31 TBC1 domain family, member 31 -1.83
ODC1 ornithine decarboxylase 1 -1.75
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) -1.31
PCLAF PCNA clamp associated factor -1.29
SYTL3 synaptotagmin-like 3 -1.28
E2F2 E2F transcription factor 2 -1.27
PTTG1 pituitary tumor-transforming 1 -1.24
MTFR2 mitochondrial fission regulator 2 -1.23
RRM2 ribonucleotide reductase M2 -1.2
HPSE heparanase -1.16
CCNA1 cyclin A1 -1.14
DEPDC7 DEP domain containing 7 -1.14
FBXO5 F-box protein 5 -1.13
PLIN2 perilipin 2 -1.13
CLSPN claspin -1.13
TK1 thymidine kinase 1, soluble -1.13
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -1.12
SCARA3 scavenger receptor class A, member 3 -1.12
EXO1 exonuclease 1 -1.12
CDC25B cell division cycle 25B -1.09
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -1.08
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.08
CCNB2 cyclin B2 -1.07
WDR76 WD repeat domain 76 -1.07
HELLS helicase, lymphoid-specific -1.06
NET1 neuroepithelial cell transforming 1 -1.04
GMNN geminin, DNA replication inhibitor -1.03
PLK1 polo-like kinase 1 -1.02
NEIL3 nei endonuclease VIII-like 3 (E. coli) -1.01
CDC6 cell division cycle 6 -1.01
CDC20 cell division cycle 20 -0.99
KIF22 kinesin family member 22 -0.98
ARID5B AT rich interactive domain 5B (MRF1-like) -0.97
GRHL1 grainyhead-like 1 (Drosophila) -0.97
MCM10 minichromosome maintenance complex component 10 -0.96
TTLL4 tubulin tyrosine ligase-like family member 4 -0.96
CCNB1 cyclin B1 -0.95
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.94
CCDC170 coiled-coil domain containing 170 -0.94
ZMYND19 zinc finger, MYND-type containing 19 -0.93
KIF20B kinesin family member 20B -0.93
DCLRE1B DNA cross-link repair 1B -0.92
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.92
CDCA2 cell division cycle associated 2 -0.92
CCNF cyclin F -0.91
ZWINT ZW10 interacting kinetochore protein -0.9
CCNA2 cyclin A2 -0.9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -0.9
CDCA7 cell division cycle associated 7 -0.88
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -0.88
SORT1 sortilin 1 -0.88
RAD51AP1 RAD51 associated protein 1 -0.88
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.87
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -0.87
ARHGAP11A Rho GTPase activating protein 11A -0.87
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.87
ZNF124 zinc finger protein 124 -0.87
RAD54L RAD54-like (S. cerevisiae) -0.86
ATAD5 ATPase family, AAA domain containing 5 -0.86
TYMS thymidylate synthetase -0.86
RFLNB refilin B -0.85
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -0.85
DNA2 DNA replication helicase/nuclease 2 -0.85
ISCA2 iron-sulfur cluster assembly 2 -0.85
TOP2A topoisomerase (DNA) II alpha 170kDa -0.84
LRRC42 leucine rich repeat containing 42 -0.84
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -0.84
ECT2 epithelial cell transforming 2 -0.83
KIF11 kinesin family member 11 -0.83
TPX2 TPX2, microtubule-associated -0.83
ZGRF1 zinc finger, GRF-type containing 1 -0.82
HOXB7 homeobox B7 -0.82
RILPL2 Rab interacting lysosomal protein-like 2 -0.82
AEBP2 AE binding protein 2 -0.81
RARA retinoic acid receptor, alpha -0.8
ANLN anillin, actin binding protein -0.8
PRR11 proline rich 11 -0.8
KIF20A kinesin family member 20A -0.79
UBE2S ubiquitin-conjugating enzyme E2S -0.78
RAD54B RAD54 homolog B (S. cerevisiae) -0.78
TACC3 transforming, acidic coiled-coil containing protein 3 -0.78
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.77
SACK1D scaffolding CK1 anchoring protein D -0.77
SLBP stem-loop binding protein -0.76
CDCA8 cell division cycle associated 8 -0.75
ZNF888 zinc finger protein 888 -0.75
CDCA5 cell division cycle associated 5 -0.75
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 -0.74
TPST2 tyrosylprotein sulfotransferase 2 -0.74
CDK6 cyclin-dependent kinase 6 -0.74
RFWD3 ring finger and WD repeat domain 3 -0.73
PSRC1 proline/serine-rich coiled-coil 1 -0.73
UCK2 uridine-cytidine kinase 2 -0.73
TCF3 transcription factor 3 -0.73
INCENP inner centromere protein antigens 135/155kDa -0.73
RNF141 ring finger protein 141 -0.73
CCDC77 coiled-coil domain containing 77 -0.72
BARD1 BRCA1 associated RING domain 1 -0.72